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MAPRE1 microtubule associated protein RP/EB family member 1 [ Homo sapiens (human) ]

Gene ID: 22919, updated on 5-Jul-2020

Summary

Official Symbol
MAPRE1provided by HGNC
Official Full Name
microtubule associated protein RP/EB family member 1provided by HGNC
Primary source
HGNC:HGNC:6890
See related
Ensembl:ENSG00000101367 MIM:603108
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EB1
Summary
The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 71.1), thyroid (RPKM 48.1) and 25 other tissues See more
Orthologs

Genomic context

See MAPRE1 in Genome Data Viewer
Location:
20q11.21
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (32819780..32850405)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (31407699..31438211)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene COMM domain containing 7 Neighboring gene DNA methyltransferase 3 beta Neighboring gene EF-hand calcium binding domain 8 Neighboring gene VISTA enhancer hs2101

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of inattention and hyperactivity-impulsivity measured as quantitative traits.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr relocalizes MAPRE1 (EB1) from the plus ends of microtubules in infected primary human macrophages PubMed
vpr EB1-mediated stable microtubules enhance HIV-1 infection and is required for efficient translocation of HIV-1 GFP-Vpr labelled viral particles across the cytoplasm PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117374, MGC129946

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
cadherin binding HDA PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule plus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule plus-end binding IDA
Inferred from Direct Assay
more info
PubMed 
protein C-terminus binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
ciliary basal body-plasma membrane docking TAS
Traceable Author Statement
more info
 
microtubule bundle formation IEA
Inferred from Electronic Annotation
more info
 
microtubule polymerization IEA
Inferred from Electronic Annotation
more info
 
negative regulation of microtubule polymerization IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration TAS
Traceable Author Statement
more info
 
positive regulation of microtubule plus-end binding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization TAS
Traceable Author Statement
more info
PubMed 
protein localization to microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization to microtubule IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
regulation of microtubule polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cell projection membrane IEA
Inferred from Electronic Annotation
more info
 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cortical microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IDA
Inferred from Direct Assay
more info
PubMed 
microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic spindle astral microtubule end IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with spindle IDA
Inferred from Direct Assay
more info
PubMed 
spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
microtubule-associated protein RP/EB family member 1
Names
APC-binding protein EB1
adenomatous polyposis coli-binding protein EB1
end-binding protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012325.3NP_036457.1  microtubule-associated protein RP/EB family member 1

    See identical proteins and their annotated locations for NP_036457.1

    Status: REVIEWED

    Source sequence(s)
    BC106068, BJ992159, BM983860
    Consensus CDS
    CCDS13208.1
    UniProtKB/Swiss-Prot
    Q15691
    Related
    ENSP00000364721.5, ENST00000375571.6
    Conserved Domains (1) summary
    cl26556
    Location:16257
    EB1; EB1-like C-terminal motif

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    32819780..32850405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528696.2XP_011526998.1  microtubule-associated protein RP/EB family member 1 isoform X1

    See identical proteins and their annotated locations for XP_011526998.1

    UniProtKB/Swiss-Prot
    Q15691
    Conserved Domains (1) summary
    cl26556
    Location:16257
    EB1; EB1-like C-terminal motif
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