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MAPRE1 microtubule associated protein RP/EB family member 1 [ Homo sapiens (human) ]

Gene ID: 22919, updated on 3-Mar-2024

Summary

Official Symbol
MAPRE1provided by HGNC
Official Full Name
microtubule associated protein RP/EB family member 1provided by HGNC
Primary source
HGNC:HGNC:6890
See related
Ensembl:ENSG00000101367 MIM:603108; AllianceGenome:HGNC:6890
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EB1
Summary
The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 71.1), thyroid (RPKM 48.1) and 25 other tissues See more
Orthologs
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Genomic context

See MAPRE1 in Genome Data Viewer
Location:
20q11.21
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (32819777..32850405)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (34546449..34577086)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (31407760..31438211)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:31290694-31291210 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31293307-31294054 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31296664-31297170 Neighboring gene Sharpr-MPRA regulatory region 13573 Neighboring gene OCT4 hESC enhancer GRCh37_chr20:31310141-31310642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31310711-31311220 Neighboring gene COMM domain containing 7 Neighboring gene Sharpr-MPRA regulatory region 10337 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31320600-31321468 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31321469-31322336 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31324911-31325766 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:31326137-31326302 Neighboring gene OCT4 hESC enhancer GRCh37_chr20:31328938-31329439 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:31329890-31330064 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31330109-31330936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12806 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12807 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr20:31331824-31332768 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr20:31334657-31335599 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31336541-31337182 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31337183-31337824 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31338467-31339107 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31337825-31338466 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:31339333-31339906 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31339907-31340480 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31340481-31341054 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31343273-31344259 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31344260-31345245 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31347799-31348347 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31348348-31348895 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31349119-31349784 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12808 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12809 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr20:31351780-31352445 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31353111-31353775 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31353776-31354439 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31355267-31355868 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31355869-31356470 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31358045-31358546 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31361516-31362222 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31362928-31363633 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31365281-31365829 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31365865-31366366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31366868-31367368 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31367369-31367869 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31367870-31368371 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31368372-31368872 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31368873-31369873 Neighboring gene DNA methyltransferase 3 beta Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31374779-31375450 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr20:31375451-31376121 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31377111-31378042 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr20:31378043-31378972 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:31385992-31387191 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31388345-31389148 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31389149-31389952 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31391821-31392634 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31394723-31395522 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31395523-31396320 Neighboring gene OCT4 hESC enhancer GRCh37_chr20:31397487-31397988 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12810 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31408139-31408808 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31408809-31409478 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31420386-31420886 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31428835-31429334 Neighboring gene uncharacterized LOC119746555 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31446596-31447408 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31462588-31463558 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31463559-31464528 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_60089 Neighboring gene EF-hand calcium binding domain 8 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:31467763-31467940 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31474801-31475642 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31479663-31480402 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31480940-31481452 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31481453-31481964 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31481965-31482476 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31482477-31482988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31494551-31495051 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31505783-31506299 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr20:31538047-31538855

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of inattention and hyperactivity-impulsivity measured as quantitative traits.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr relocalizes MAPRE1 (EB1) from the plus ends of microtubules in infected primary human macrophages PubMed
vpr EB1-mediated stable microtubules enhance HIV-1 infection and is required for efficient translocation of HIV-1 GFP-Vpr labelled viral particles across the cytoplasm PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC117374, MGC129946

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables cadherin binding HDA PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables microtubule plus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule plus-end binding IDA
Inferred from Direct Assay
more info
PubMed 
enables molecular adaptor activity EXP
Inferred from Experiment
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of mitotic spindle orientation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in microtubule bundle formation IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule polymerization IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of microtubule polymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in non-motile cilium assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization TAS
Traceable Author Statement
more info
PubMed 
involved_in protein localization to astral microtubule IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to centrosome IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein localization to microtubule IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of microtubule polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection membrane IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in ciliary basal body IEA
Inferred from Electronic Annotation
more info
 
located_in cortical microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitotic spindle astral microtubule end IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitotic spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with spindle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
microtubule-associated protein RP/EB family member 1
Names
APC-binding protein EB1
adenomatous polyposis coli-binding protein EB1
end-binding protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012325.3NP_036457.1  microtubule-associated protein RP/EB family member 1

    See identical proteins and their annotated locations for NP_036457.1

    Status: REVIEWED

    Source sequence(s)
    BC106068, BJ992159, BM983860
    Consensus CDS
    CCDS13208.1
    UniProtKB/Swiss-Prot
    B2R6I7, E1P5M8, Q15691, Q3KQS8
    UniProtKB/TrEMBL
    B4DM33
    Related
    ENSP00000364721.5, ENST00000375571.6
    Conserved Domains (1) summary
    COG5217
    Location:16257
    BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    32819777..32850405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528696.3XP_011526998.1  microtubule-associated protein RP/EB family member 1 isoform X1

    See identical proteins and their annotated locations for XP_011526998.1

    UniProtKB/Swiss-Prot
    B2R6I7, E1P5M8, Q15691, Q3KQS8
    UniProtKB/TrEMBL
    B4DM33
    Conserved Domains (1) summary
    COG5217
    Location:16257
    BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    34546449..34577086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323204.1XP_054179179.1  microtubule-associated protein RP/EB family member 1 isoform X1

    UniProtKB/Swiss-Prot
    B2R6I7, E1P5M8, Q15691, Q3KQS8
    UniProtKB/TrEMBL
    B4DM33