Format

Send to:

Choose Destination

CD93 CD93 molecule [ Homo sapiens (human) ]

Gene ID: 22918, updated on 13-Mar-2020

Summary

Official Symbol
CD93provided by HGNC
Official Full Name
CD93 moleculeprovided by HGNC
Primary source
HGNC:HGNC:15855
See related
Ensembl:ENSG00000125810 MIM:120577
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C1QR1; C1qRP; CDw93; ECSM3; MXRA4; C1qR(P); dJ737E23.1
Summary
The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton. [provided by RefSeq, Jul 2008]
Expression
Broad expression in placenta (RPKM 64.0), lung (RPKM 47.5) and 21 other tissues See more
Orthologs

Genomic context

See CD93 in Genome Data Viewer
Location:
20p11.21
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (23076554..23086830, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (23059993..23066977, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene somatostatin receptor 4 Neighboring gene thrombomodulin Neighboring gene long intergenic non-protein coding RNA 656 Neighboring gene Sharpr-MPRA regulatory region 14145

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of liver enzymes in korean children.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
complement component C1q binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
transforming growth factor beta binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
macrophage activation NAS
Non-traceable Author Statement
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
phagocytosis NAS
Non-traceable Author Statement
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
 
ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
secretory granule membrane TAS
Traceable Author Statement
more info
 
specific granule membrane TAS
Traceable Author Statement
more info
 
tertiary granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
complement component C1q receptor
Names
C1q receptor 1
C1q/MBL/SPA receptor
C1qR
CD93 antigen
complement component 1 q subcomponent receptor 1
matrix-remodeling-associated protein 4
matrix-remodelling associated 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012072.4NP_036204.2  complement component C1q receptor precursor

    See identical proteins and their annotated locations for NP_036204.2

    Status: REVIEWED

    Source sequence(s)
    AL118508, BC028075, U94333
    Consensus CDS
    CCDS13149.1
    UniProtKB/Swiss-Prot
    Q9NPY3
    Related
    ENSP00000246006.4, ENST00000246006.5
    Conserved Domains (6) summary
    cd03600
    Location:31184
    CLECT_thrombomodulin_like; C-type lectin-like domain (CTLD) of the type found in human thrombomodulin(TM), Endosialin, C14orf27, and C1qR
    smart00179
    Location:427468
    EGF_CA; Calcium-binding EGF-like domain
    pfam07645
    Location:385425
    EGF_CA; Calcium-binding EGF domain
    pfam09422
    Location:464549
    WTX; WTX protein
    pfam12662
    Location:326348
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:264300
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    23076554..23086830 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001754208.2 RNA Sequence

Support Center