U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RALY RALY heterogeneous nuclear ribonucleoprotein [ Homo sapiens (human) ]

Gene ID: 22913, updated on 19-Sep-2024

Summary

Official Symbol
RALYprovided by HGNC
Official Full Name
RALY heterogeneous nuclear ribonucleoproteinprovided by HGNC
Primary source
HGNC:HGNC:15921
See related
Ensembl:ENSG00000125970 MIM:614663; AllianceGenome:HGNC:15921
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P542; HNRPCL2
Summary
This gene encodes a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) gene family. This protein may play a role in pre-mRNA splicing and in embryonic development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Expression
Ubiquitous expression in bone marrow (RPKM 18.7), testis (RPKM 18.3) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See RALY in Genome Data Viewer
Location:
20q11.22
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (33993911..34084884)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (35720262..35811292)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (32581717..32672690)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr20:32507904-32508103 Neighboring gene tropomyosin 3 pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:32521004-32521504 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class P pseudogene 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:32580634-32581160 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12828 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12829 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12831 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12830 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:32586597-32587097 Neighboring gene RALY antisense RNA 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:32598140-32598817 Neighboring gene Sharpr-MPRA regulatory region 13564 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:32633616-32634424 Neighboring gene microRNA 4755 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:32664206-32665405 Neighboring gene eukaryotic translation initiation factor 2 subunit beta Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:32698990-32699652 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:32699653-32700314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17755 Neighboring gene ribosomal protein S2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC117312

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coregulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in cholesterol homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
RNA-binding protein Raly
Names
RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog)
RNA-binding protein (autoantigenic)
RNA-binding protein (autoantigenic, hnRNP-associated with lethal yellow)
autoantigen p542
heterogeneous nuclear ribonucleoprotein C-like 2
hnRNP associated with lethal yellow protein homolog
hnRNP core protein C-like 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007367.4NP_031393.2  RNA-binding protein Raly isoform 2

    See identical proteins and their annotated locations for NP_031393.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. This isoform is also known as short isoform.
    Source sequence(s)
    AK226085, AL031668, BM680768
    Consensus CDS
    CCDS13229.1
    UniProtKB/TrEMBL
    A8K4T9
    Related
    ENSP00000364255.3, ENST00000375114.7
    Conserved Domains (2) summary
    COG0724
    Location:12106
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12604
    Location:2095
    RRM_RALY; RNA recognition motif in vertebrate RNA-binding protein Raly
  2. NM_016732.3NP_057951.1  RNA-binding protein Raly isoform 1

    See identical proteins and their annotated locations for NP_057951.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). This isoform is also known as long isoform.
    Source sequence(s)
    AK222915, AL031668, BG751407, BM680768
    Consensus CDS
    CCDS13230.1
    UniProtKB/Swiss-Prot
    Q14621, Q2M365, Q5QPL8, Q9BQX6, Q9UJE3, Q9UKM9
    UniProtKB/TrEMBL
    A8K4T9
    Related
    ENSP00000246194.3, ENST00000246194.8
    Conserved Domains (1) summary
    cd12604
    Location:2095
    RRM_RALY; RNA recognition motif in vertebrate RNA-binding protein Raly

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    33993911..34084884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528695.4XP_011526997.1  RNA-binding protein Raly isoform X1

    See identical proteins and their annotated locations for XP_011526997.1

    UniProtKB/Swiss-Prot
    Q14621, Q2M365, Q5QPL8, Q9BQX6, Q9UJE3, Q9UKM9
    UniProtKB/TrEMBL
    A8K4T9
    Conserved Domains (1) summary
    cd12604
    Location:2095
    RRM_RALY; RNA recognition motif in vertebrate RNA-binding protein Raly
  2. XM_005260334.6XP_005260391.1  RNA-binding protein Raly isoform X1

    See identical proteins and their annotated locations for XP_005260391.1

    UniProtKB/Swiss-Prot
    Q14621, Q2M365, Q5QPL8, Q9BQX6, Q9UJE3, Q9UKM9
    UniProtKB/TrEMBL
    A8K4T9
    Conserved Domains (1) summary
    cd12604
    Location:2095
    RRM_RALY; RNA recognition motif in vertebrate RNA-binding protein Raly
  3. XM_017027731.3XP_016883220.1  RNA-binding protein Raly isoform X1

    UniProtKB/Swiss-Prot
    Q14621, Q2M365, Q5QPL8, Q9BQX6, Q9UJE3, Q9UKM9
    UniProtKB/TrEMBL
    A8K4T9
    Conserved Domains (1) summary
    cd12604
    Location:2095
    RRM_RALY; RNA recognition motif in vertebrate RNA-binding protein Raly
  4. XM_005260336.6XP_005260393.1  RNA-binding protein Raly isoform X2

    See identical proteins and their annotated locations for XP_005260393.1

    UniProtKB/TrEMBL
    A8K4T9
    Conserved Domains (2) summary
    COG0724
    Location:12106
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12604
    Location:2095
    RRM_RALY; RNA recognition motif in vertebrate RNA-binding protein Raly
  5. XM_047440016.1XP_047295972.1  RNA-binding protein Raly isoform X2

    UniProtKB/TrEMBL
    A8K4T9
    Related
    ENSP00000415973.1, ENST00000442805.1
  6. XM_047440015.1XP_047295971.1  RNA-binding protein Raly isoform X1

    UniProtKB/Swiss-Prot
    Q14621, Q2M365, Q5QPL8, Q9BQX6, Q9UJE3, Q9UKM9
    UniProtKB/TrEMBL
    A8K4T9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    35720262..35811292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323201.1XP_054179176.1  RNA-binding protein Raly isoform X1

    UniProtKB/TrEMBL
    A8K4T9, Q53GL6
  2. XM_054323199.1XP_054179174.1  RNA-binding protein Raly isoform X1

    UniProtKB/TrEMBL
    A8K4T9, Q53GL6
  3. XM_054323200.1XP_054179175.1  RNA-binding protein Raly isoform X1

    UniProtKB/TrEMBL
    A8K4T9, Q53GL6
  4. XM_054323203.1XP_054179178.1  RNA-binding protein Raly isoform X2

    UniProtKB/TrEMBL
    A8K4T9
  5. XM_054323202.1XP_054179177.1  RNA-binding protein Raly isoform X1

    UniProtKB/TrEMBL
    A8K4T9, Q53GL6