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RALY RALY heterogeneous nuclear ribonucleoprotein [ Homo sapiens (human) ]

Gene ID: 22913, updated on 6-Jan-2019

Summary

Official Symbol
RALYprovided by HGNC
Official Full Name
RALY heterogeneous nuclear ribonucleoproteinprovided by HGNC
Primary source
HGNC:HGNC:15921
See related
Ensembl:ENSG00000125970 MIM:614663
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P542; HNRPCL2
Summary
This gene encodes a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) gene family. This protein may play a role in pre-mRNA splicing and in embryonic development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Expression
Ubiquitous expression in bone marrow (RPKM 18.7), testis (RPKM 18.3) and 25 other tissues See more
Orthologs

Genomic context

See RALY in Genome Data Viewer
Location:
20q11.22
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (33993652..34084884)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (32581458..32670991)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene tropomyosin 3 pseudogene 2 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class P pseudogene 3 Neighboring gene RALY antisense RNA 1 Neighboring gene microRNA 4755 Neighboring gene eukaryotic translation initiation factor 2 subunit beta Neighboring gene ribosomal protein S2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117312

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coregulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cholesterol homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
regulation of nucleic acid-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
RNA-binding protein Raly
Names
RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog)
RNA-binding protein (autoantigenic)
RNA-binding protein (autoantigenic, hnRNP-associated with lethal yellow)
autoantigen p542
heterogeneous nuclear ribonucleoprotein C-like 2
hnRNP associated with lethal yellow protein homolog
hnRNP core protein C-like 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007367.3NP_031393.2  RNA-binding protein Raly isoform 2

    See identical proteins and their annotated locations for NP_031393.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. This isoform is also known as short isoform.
    Source sequence(s)
    AK226085, AL031668, BG751407, BM680768
    Consensus CDS
    CCDS13229.1
    UniProtKB/Swiss-Prot
    Q9UKM9
    Related
    ENSP00000364255.3, ENST00000375114.7
    Conserved Domains (2) summary
    COG0724
    Location:12106
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12604
    Location:2095
    RRM_RALY; RNA recognition motif in vertebrate RNA-binding protein Raly
  2. NM_016732.3NP_057951.1  RNA-binding protein Raly isoform 1

    See identical proteins and their annotated locations for NP_057951.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). This isoform is also known as long isoform.
    Source sequence(s)
    AK222915, AL031668, BG751407, BM680768
    Consensus CDS
    CCDS13230.1
    UniProtKB/Swiss-Prot
    Q9UKM9
    UniProtKB/TrEMBL
    Q53GL6
    Related
    ENSP00000246194.3, ENST00000246194.7
    Conserved Domains (1) summary
    cd12604
    Location:2095
    RRM_RALY; RNA recognition motif in vertebrate RNA-binding protein Raly

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

    Range
    33993652..34084884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451859.1XP_024307627.1  RNA-binding protein Raly isoform X1

    Conserved Domains (1) summary
    cd12604
    Location:2095
    RRM_RALY; RNA recognition motif in vertebrate RNA-binding protein Raly
  2. XM_017027731.2XP_016883220.1  RNA-binding protein Raly isoform X1

    UniProtKB/Swiss-Prot
    Q9UKM9
    Conserved Domains (1) summary
    cd12604
    Location:2095
    RRM_RALY; RNA recognition motif in vertebrate RNA-binding protein Raly
  3. XM_005260334.5XP_005260391.1  RNA-binding protein Raly isoform X1

    See identical proteins and their annotated locations for XP_005260391.1

    UniProtKB/Swiss-Prot
    Q9UKM9
    Conserved Domains (1) summary
    cd12604
    Location:2095
    RRM_RALY; RNA recognition motif in vertebrate RNA-binding protein Raly
  4. XM_005260336.5XP_005260393.1  RNA-binding protein Raly isoform X2

    See identical proteins and their annotated locations for XP_005260393.1

    UniProtKB/Swiss-Prot
    Q9UKM9
    Related
    ENSP00000415973.1, ENST00000442805.1
    Conserved Domains (2) summary
    COG0724
    Location:12106
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12604
    Location:2095
    RRM_RALY; RNA recognition motif in vertebrate RNA-binding protein Raly
  5. XM_011528695.3XP_011526997.1  RNA-binding protein Raly isoform X1

    See identical proteins and their annotated locations for XP_011526997.1

    UniProtKB/Swiss-Prot
    Q9UKM9
    Conserved Domains (1) summary
    cd12604
    Location:2095
    RRM_RALY; RNA recognition motif in vertebrate RNA-binding protein Raly
  6. XM_024451858.1XP_024307626.1  RNA-binding protein Raly isoform X1

    Conserved Domains (1) summary
    cd12604
    Location:2095
    RRM_RALY; RNA recognition motif in vertebrate RNA-binding protein Raly
  7. XM_011528694.3XP_011526996.1  RNA-binding protein Raly isoform X1

    See identical proteins and their annotated locations for XP_011526996.1

    UniProtKB/Swiss-Prot
    Q9UKM9
    Conserved Domains (1) summary
    cd12604
    Location:2095
    RRM_RALY; RNA recognition motif in vertebrate RNA-binding protein Raly
  8. XM_024451857.1XP_024307625.1  RNA-binding protein Raly isoform X1

    Conserved Domains (1) summary
    cd12604
    Location:2095
    RRM_RALY; RNA recognition motif in vertebrate RNA-binding protein Raly
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