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TRAK1 trafficking kinesin protein 1 [ Homo sapiens (human) ]

Gene ID: 22906, updated on 21-Oct-2018

Summary

Official Symbol
TRAK1provided by HGNC
Official Full Name
trafficking kinesin protein 1provided by HGNC
Primary source
HGNC:HGNC:29947
See related
Ensembl:ENSG00000182606 MIM:608112; Vega:OTTHUMG00000131795
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MILT1; OIP106
Expression
Ubiquitous expression in heart (RPKM 17.5), stomach (RPKM 12.1) and 24 other tissues See more
Orthologs

Genomic context

See TRAK1 in Genome Data Viewer
Location:
3p22.1
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (42013802..42225890)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (42055294..42267382)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene gem nuclear organelle associated protein 2 pseudogene 2 Neighboring gene uncharacterized LOC107986077 Neighboring gene thiopurine S-methyltransferase pseudogene 2 Neighboring gene RNA, U4 small nuclear 78, pseudogene Neighboring gene uncharacterized LOC105377048 Neighboring gene cholecystokinin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog

Pathways from BioSystems

  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Diseases of signal transduction, organism-specific biosystem (from REACTOME)
    Diseases of signal transduction, organism-specific biosystemSignaling processes are central to human physiology (e.g., Pires-da Silva & Sommer 2003), and their disruption by either germ-line and somatic mutation can lead to serious disease. Here, the molecula...
  • Oncogenic MAPK signaling, organism-specific biosystem (from REACTOME)
    Oncogenic MAPK signaling, organism-specific biosystemThe importance of the RAS/RAF/MAPK cascade in regulating cellular proliferation, differentiation and survival is highlighted by the fact that components of the pathway are mutated with high frequency...
  • Signaling by BRAF and RAF fusions, organism-specific biosystem (from REACTOME)
    Signaling by BRAF and RAF fusions, organism-specific biosystemIn addition to the more prevalent point mutations, BRAF and RAF1 are also subject to activation as a result of translocation events that yield truncated or fusion products (Jones et al, 2008; Cin et ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GABA receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
TPR domain binding IEA
Inferred from Electronic Annotation
more info
 
myosin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
anterograde axonal transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anterograde axonal transport of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 
endosome to lysosome transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosome to lysosome transport IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion distribution IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of axonogenesis IEA
Inferred from Electronic Annotation
more info
 
protein O-linked glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein targeting IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein targeting ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
vesicle transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
axon cytoplasm IEA
Inferred from Electronic Annotation
more info
 
axonal growth cone IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
early endosome IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
trafficking kinesin-binding protein 1
Names
106 kDa O-GlcNAc transferase-interacting protein
O-linked N-acetylglucosamine transferase interacting protein 106
OGT(O-Glc-NAc transferase)-interacting protein 106 KDa
milton homolog 1
protein Milton
trafficking protein, kinesin binding 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042646.2NP_001036111.1  trafficking kinesin-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001036111.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AB028965, AC018358, H05058
    Consensus CDS
    CCDS43072.1
    UniProtKB/Swiss-Prot
    Q9UPV9
    UniProtKB/TrEMBL
    A0A024R2M0
    Related
    ENSP00000328998.5, OTTHUMP00000209384, ENST00000327628.9, OTTHUMT00000343413
    Conserved Domains (2) summary
    pfam04849
    Location:50353
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:416583
    Milton; Kinesin associated protein
  2. NM_001265608.1NP_001252537.1  trafficking kinesin-binding protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA534633, AB028965, AC018358, AK316260
    UniProtKB/Swiss-Prot
    Q9UPV9
    UniProtKB/TrEMBL
    B7ZAE5
    Conserved Domains (3) summary
    pfam04849
    Location:50353
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:424583
    Milton; Kinesin associated protein
    cl21478
    Location:264356
    ATP-synt_B; ATP synthase B/B' CF(0)
  3. NM_001265609.1NP_001252538.1  trafficking kinesin-binding protein 1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' and 3' UTRs and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) is shorter and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AA534633, AC018358, AK294221, DA193280
    Consensus CDS
    CCDS74922.1
    UniProtKB/TrEMBL
    A0A087X0N0, B7Z218
    Related
    ENSP00000483516.1, ENST00000613405.4
    Conserved Domains (3) summary
    pfam12448
    Location:350509
    Milton; Kinesin associated protein
    pfam14662
    Location:51267
    KASH_CCD; Coiled-coil region of CCDC155 or KASH
    cl21478
    Location:190282
    ATP-synt_B; ATP synthase B/B' CF(0)
  4. NM_001265610.1NP_001252539.1  trafficking kinesin-binding protein 1 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' and 3' UTRs and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (5) is shorter and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AC018358, AL713787, DA193280
    Consensus CDS
    CCDS58826.1
    UniProtKB/Swiss-Prot
    Q9UPV9
    Related
    ENSP00000410717.1, OTTHUMP00000209370, ENST00000449246.5, OTTHUMT00000343383
    Conserved Domains (2) summary
    pfam04849
    Location:22279
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:342508
    Milton; Kinesin associated protein
  5. NM_001349245.1NP_001336174.1  trafficking kinesin-binding protein 1 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) encodes isoform 6.
    Source sequence(s)
    AC018358, AC093414
    Conserved Domains (2) summary
    pfam04849
    Location:1249
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:312479
    Milton; Kinesin associated protein
  6. NM_001349246.1NP_001336175.1  trafficking kinesin-binding protein 1 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) encodes isoform 7.
    Source sequence(s)
    AC018358, AC093414
    Conserved Domains (2) summary
    pfam04849
    Location:50353
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:416583
    Milton; Kinesin associated protein
  7. NM_001349247.1NP_001336176.1  trafficking kinesin-binding protein 1 isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) encodes isoform 8.
    Source sequence(s)
    AC018358, AC093414
    Conserved Domains (2) summary
    pfam04849
    Location:50353
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:416583
    Milton; Kinesin associated protein
  8. NM_001349248.1NP_001336177.1  trafficking kinesin-binding protein 1 isoform 9

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) encodes isoform 9.
    Source sequence(s)
    AC018358, AC093414
    Conserved Domains (2) summary
    pfam04849
    Location:22279
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:342509
    Milton; Kinesin associated protein
  9. NM_001349249.1NP_001336178.1  trafficking kinesin-binding protein 1 isoform 10

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) encodes isoform 10.
    Source sequence(s)
    AC018358, AC093414
    Conserved Domains (2) summary
    pfam04849
    Location:22279
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:342509
    Milton; Kinesin associated protein
  10. NM_014965.4NP_055780.2  trafficking kinesin-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_055780.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' and 3' UTRs and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AA534633, AC018358, AK316260, AL713787, BX647199
    Consensus CDS
    CCDS2695.1
    UniProtKB/Swiss-Prot
    Q9UPV9
    UniProtKB/TrEMBL
    B7ZAE5
    Related
    ENSP00000340702.3, OTTHUMP00000197001, ENST00000341421.7, OTTHUMT00000317460
    Conserved Domains (3) summary
    pfam04849
    Location:15295
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:366525
    Milton; Kinesin associated protein
    cl21478
    Location:206298
    ATP-synt_B; ATP synthase B/B' CF(0)

RNA

  1. NR_146089.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC018358, AC093414

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    42013802..42225890
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453401.1XP_024309169.1  trafficking kinesin-binding protein 1 isoform X1

    Conserved Domains (2) summary
    pfam04849
    Location:50353
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:416583
    Milton; Kinesin associated protein
  2. XM_017005906.1XP_016861395.1  trafficking kinesin-binding protein 1 isoform X2

  3. XM_017005909.1XP_016861398.1  trafficking kinesin-binding protein 1 isoform X7

  4. XM_017005911.1XP_016861400.1  trafficking kinesin-binding protein 1 isoform X8

    Related
    ENSP00000486713.1, OTTHUMP00000278239, ENST00000487159.5, OTTHUMT00000343454
    Conserved Domains (2) summary
    pfam04849
    Location:1249
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:312479
    Milton; Kinesin associated protein
  5. XM_024453400.1XP_024309168.1  trafficking kinesin-binding protein 1 isoform X1

    Conserved Domains (2) summary
    pfam04849
    Location:50353
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:416583
    Milton; Kinesin associated protein
  6. XM_024453404.1XP_024309172.1  trafficking kinesin-binding protein 1 isoform X9

    Conserved Domains (2) summary
    pfam04849
    Location:50353
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:416583
    Milton; Kinesin associated protein
  7. XM_024453402.1XP_024309170.1  trafficking kinesin-binding protein 1 isoform X3

    Conserved Domains (2) summary
    pfam04849
    Location:50353
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:416583
    Milton; Kinesin associated protein
  8. XM_017005913.2XP_016861402.1  trafficking kinesin-binding protein 1 isoform X10

  9. XM_024453403.1XP_024309171.1  trafficking kinesin-binding protein 1 isoform X4

    Conserved Domains (2) summary
    pfam04849
    Location:50353
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:416583
    Milton; Kinesin associated protein
  10. XM_006713029.3XP_006713092.1  trafficking kinesin-binding protein 1 isoform X11

    See identical proteins and their annotated locations for XP_006713092.1

    Conserved Domains (3) summary
    pfam04849
    Location:50353
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:424583
    Milton; Kinesin associated protein
    cl21478
    Location:264356
    ATP-synt_B; ATP synthase B/B' CF(0)
  11. XM_006713030.3XP_006713093.1  trafficking kinesin-binding protein 1 isoform X13

    See identical proteins and their annotated locations for XP_006713093.1

    Conserved Domains (3) summary
    pfam04849
    Location:50353
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:424583
    Milton; Kinesin associated protein
    cl21478
    Location:264356
    ATP-synt_B; ATP synthase B/B' CF(0)
  12. XM_005264962.4XP_005265019.1  trafficking kinesin-binding protein 1 isoform X11

    See identical proteins and their annotated locations for XP_005265019.1

    Conserved Domains (3) summary
    pfam04849
    Location:50353
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:424583
    Milton; Kinesin associated protein
    cl21478
    Location:264356
    ATP-synt_B; ATP synthase B/B' CF(0)
  13. XM_005264963.4XP_005265020.1  trafficking kinesin-binding protein 1 isoform X13

    See identical proteins and their annotated locations for XP_005265020.1

    Conserved Domains (3) summary
    pfam04849
    Location:50353
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:424583
    Milton; Kinesin associated protein
    cl21478
    Location:264356
    ATP-synt_B; ATP synthase B/B' CF(0)
  14. XM_011533489.3XP_011531791.1  trafficking kinesin-binding protein 1 isoform X12

    Conserved Domains (3) summary
    pfam04849
    Location:50353
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:424583
    Milton; Kinesin associated protein
    cl21478
    Location:264356
    ATP-synt_B; ATP synthase B/B' CF(0)
  15. XM_006713031.4XP_006713094.1  trafficking kinesin-binding protein 1 isoform X14

    Conserved Domains (3) summary
    pfam04849
    Location:50353
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:424583
    Milton; Kinesin associated protein
    cl21478
    Location:264356
    ATP-synt_B; ATP synthase B/B' CF(0)
  16. XM_017005908.1XP_016861397.1  trafficking kinesin-binding protein 1 isoform X6

  17. XM_017005907.2XP_016861396.1  trafficking kinesin-binding protein 1 isoform X5

    Related
    ENSP00000379478.1, OTTHUMP00000162606, ENST00000396175.5

RNA

  1. XR_001740060.1 RNA Sequence

  2. XR_001740058.2 RNA Sequence

  3. XR_001740059.2 RNA Sequence

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