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Zgpat zinc finger, CCCH-type with G patch domain [ Mus musculus (house mouse) ]

Gene ID: 229007, updated on 26-Sep-2022

Summary

Official Symbol
Zgpatprovided by MGI
Official Full Name
zinc finger, CCCH-type with G patch domainprovided by MGI
Primary source
MGI:MGI:2449939
See related
Ensembl:ENSMUSG00000027582 AllianceGenome:MGI:2449939
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1500006I01Rik
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of epidermal growth factor-activated receptor activity and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in nucleus. Is expressed in central nervous system; early conceptus; gut epithelium; peripheral nervous system ganglion; and respiratory system. Orthologous to human ZGPAT (zinc finger CCCH-type and G-patch domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 31.8), CNS E14 (RPKM 31.1) and 28 other tissues See more
Orthologs
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Genomic context

See Zgpat in Genome Data Viewer
Location:
2; 2 H4
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (181006724..181022586)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (181364931..181380793)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene stathmin-like 3 Neighboring gene regulator of telomere elongation helicase 1 Neighboring gene ADP-ribosylation factor related protein 1 Neighboring gene zinc finger and BTB domain containing 46 Neighboring gene Slc2a4 regulator, pseudogene Neighboring gene Lck interacting transmembrane adaptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: Lime1

Homology

Clone Names

  • MGC25688, MGC38468

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
zinc finger CCCH-type with G patch domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048148.1NP_001041613.1  zinc finger CCCH-type with G patch domain-containing protein

    See identical proteins and their annotated locations for NP_001041613.1

    Status: VALIDATED

    Source sequence(s)
    AK041491, AK159801, BY467113
    Consensus CDS
    CCDS17210.1
    UniProtKB/Swiss-Prot
    Q8BWW2, Q8VDM1
    Related
    ENSMUSP00000104435.3, ENSMUST00000108807.9
    Conserved Domains (4) summary
    cd04508
    Location:220266
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    smart00356
    Location:177198
    ZnF_C3H1; zinc finger
    pfam01585
    Location:313354
    G-patch; G-patch domain
    cl23720
    Location:392507
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  2. NM_144894.3NP_659143.1  zinc finger CCCH-type with G patch domain-containing protein

    See identical proteins and their annotated locations for NP_659143.1

    Status: VALIDATED

    Source sequence(s)
    AK041491, BY287149, BY467113
    Consensus CDS
    CCDS17210.1
    UniProtKB/Swiss-Prot
    Q8BWW2, Q8VDM1
    Related
    ENSMUSP00000029105.6, ENSMUST00000029105.12
    Conserved Domains (4) summary
    cd04508
    Location:220266
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    smart00356
    Location:177198
    ZnF_C3H1; zinc finger
    pfam01585
    Location:313354
    G-patch; G-patch domain
    cl23720
    Location:392507
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    181006724..181022586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)