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CARD8 caspase recruitment domain family member 8 [ Homo sapiens (human) ]

Gene ID: 22900, updated on 17-Jun-2019

Summary

Official Symbol
CARD8provided by HGNC
Official Full Name
caspase recruitment domain family member 8provided by HGNC
Primary source
HGNC:HGNC:17057
See related
Ensembl:ENSG00000105483 MIM:609051
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NDPP; DACAR; DAKAR; NDPP1; TUCAN; CARDINAL
Summary
The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
Expression
Broad expression in spleen (RPKM 13.6), lymph node (RPKM 11.5) and 24 other tissues See more
Orthologs

Genomic context

See CARD8 in Genome Data Viewer
Location:
19q13.33
Exon count:
21
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (48203148..48256264, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48711343..48759203, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene DNA ligase 1 Neighboring gene uncharacterized LOC107985293 Neighboring gene zinc finger SWIM-type containing 9 Neighboring gene CARD8 antisense RNA 1 Neighboring gene vomeronasal 1 receptor 97 pseudogene Neighboring gene ZNF114 antisense RNA 1 Neighboring gene zinc finger protein 114 Neighboring gene coiled-coil domain containing 114 Neighboring gene Sharpr-MPRA regulatory region 73

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
  • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
    NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
  • Nucleotide-binding Oligomerization Domain (NOD) pathway, organism-specific biosystem (from WikiPathways)
    Nucleotide-binding Oligomerization Domain (NOD) pathway, organism-specific biosystemThe NOD (nucleotide-binding oligomerization domain) proteins NOD1 and NOD2 have important roles in innate immunity as sensors of microbial components derived from bacterial peptidoglycan. The importa...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ18119, FLJ18121, KIAA0955, MGC57162, DKFZp779L0366

Gene Ontology Provided by GOA

Function Evidence Code Pubs
CARD domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
NACHT domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
cysteine-type endopeptidase activator activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cysteine-type endopeptidase activator activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
NLRP3 inflammasome complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NLRP3 inflammasome complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
inflammasome complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
caspase recruitment domain-containing protein 8
Names
CARD inhibitor of NF-kappaB-activating ligands
apoptotic protein NDPP1
tumor up-regulated CARD-containing antagonist of CASP9
tumor up-regulated CARD-containing antagonist of caspase nine

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029574.2 RefSeqGene

    Range
    5324..53184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184900.3NP_001171829.1  caspase recruitment domain-containing protein 8 isoform a

    See identical proteins and their annotated locations for NP_001171829.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a, also referred to as T60). Variants 1 and 10 encode the same protein (isoform a).
    Source sequence(s)
    AC011466, BC056891, CA448628, CB119078, DC404273, EU118120
    Consensus CDS
    CCDS54289.1
    UniProtKB/Swiss-Prot
    Q9Y2G2
    Related
    ENSP00000499211.1, ENST00000651546.1
    Conserved Domains (2) summary
    pfam00619
    Location:453535
    CARD; Caspase recruitment domain
    pfam13553
    Location:182436
    FIIND; Function to find
  2. NM_001184901.1NP_001171830.1  caspase recruitment domain-containing protein 8 isoform b

    See identical proteins and their annotated locations for NP_001171830.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a. Variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AC011466, AK297045, AK297069, BC046136, CA448628
    Consensus CDS
    CCDS12712.2
    UniProtKB/Swiss-Prot
    Q9Y2G2
    Related
    ENSP00000391248.2, ENST00000447740.6
    Conserved Domains (2) summary
    pfam00619
    Location:403485
    CARD; Caspase recruitment domain
    pfam13553
    Location:132386
    FIIND; Function to find
  3. NM_001184902.2NP_001171831.1  caspase recruitment domain-containing protein 8 isoform c

    See identical proteins and their annotated locations for NP_001171831.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate exon in the 3' coding region, which results in a frameshift compared to variant 1. This results in a shorter protein (isoform c), compared to isoform a. Variants 4 and 5 encode the same isoform (c).
    Source sequence(s)
    AC011466, AF322184, AF511652, BC056891, CA448628, CB119078, DC404273
    Consensus CDS
    CCDS54288.1
    UniProtKB/Swiss-Prot
    Q9Y2G2
    Related
    ENSP00000429839.1, ENST00000520753.5
    Conserved Domains (1) summary
    pfam13553
    Location:182387
    FIIND; Function to find
  4. NM_001184903.1NP_001171832.1  caspase recruitment domain-containing protein 8 isoform c

    See identical proteins and their annotated locations for NP_001171832.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate exon in the 3' coding region, which results in a frameshift compared to variant 1. This results in a shorter protein (isoform c), compared to isoform a. Variants 4 and 5 encode the same isoform (c).
    Source sequence(s)
    AC011466, AF322184, AK297045, BC046136, CA448628
    Consensus CDS
    CCDS54288.1
    UniProtKB/Swiss-Prot
    Q9Y2G2
    Related
    ENSP00000430747.1, ENST00000520015.5
    Conserved Domains (1) summary
    pfam13553
    Location:182387
    FIIND; Function to find
  5. NM_001184904.1NP_001171833.1  caspase recruitment domain-containing protein 8 isoform d

    See identical proteins and their annotated locations for NP_001171833.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, 3' coding region, and 3' UTR compared to variant 1. The resulting isoform (d) is shorter than isoform a.
    Source sequence(s)
    AC011466, AI040349, BC046136, DC404273
    Consensus CDS
    CCDS54287.1
    UniProtKB/TrEMBL
    E5RFV9
    Related
    ENSP00000430108.1, ENST00000519332.5
  6. NM_001351782.2NP_001338711.1  caspase recruitment domain-containing protein 8 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1 and 10 encode the same protein (isoform a).
    Source sequence(s)
    AC011466, BC056891, CA448628, CB119078, DC404273, EU118120
    Consensus CDS
    CCDS54289.1
    Related
    ENSP00000428883.1, ENST00000519940.6
    Conserved Domains (2) summary
    pfam00619
    Location:453535
    CARD; Caspase recruitment domain
    pfam13553
    Location:182436
    FIIND; Function to find
  7. NM_001351783.2NP_001338712.1  caspase recruitment domain-containing protein 8 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC008392, AC011466, AF322184, AF511652, BC045539, BC056891, CA389350, CA448628, DC404273
    Consensus CDS
    CCDS12712.2
    Conserved Domains (2) summary
    pfam00619
    Location:403485
    CARD; Caspase recruitment domain
    pfam13553
    Location:132386
    FIIND; Function to find
  8. NM_001351784.2NP_001338713.1  caspase recruitment domain-containing protein 8 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF322184, AF511652, BC056891, CA448628, CR983845, DC347384, DC382648, DC404273
    Conserved Domains (2) summary
    pfam00619
    Location:348430
    CARD; Caspase recruitment domain
    pfam13553
    Location:77331
    FIIND; Function to find
  9. NM_001351786.2NP_001338715.1  caspase recruitment domain-containing protein 8 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF322184, AF511652, BC056891, CA448628, CR983845, DC382648, DC404273
    Conserved Domains (2) summary
    pfam00619
    Location:341423
    CARD; Caspase recruitment domain
    pfam13553
    Location:70324
    FIIND; Function to find
  10. NM_001351787.1NP_001338716.1  caspase recruitment domain-containing protein 8 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF143869, AK302327, DC382648, DC404273
    Conserved Domains (1) summary
    pfam13553
    Location:77331
    FIIND; Function to find
  11. NM_001351788.2NP_001338717.1  caspase recruitment domain-containing protein 8 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF322184, AF511652, BC056891, CA448628, DC382648, DC404273
    Conserved Domains (1) summary
    pfam13553
    Location:132337
    FIIND; Function to find
  12. NM_001351789.2NP_001338718.1  caspase recruitment domain-containing protein 8 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF322184, AF511652, BC056891, CA448628, DC382648, DC404273
    Conserved Domains (1) summary
    pfam13553
    Location:132337
    FIIND; Function to find
  13. NM_001351790.2NP_001338719.1  caspase recruitment domain-containing protein 8 isoform i

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF322184, AF511652, BC056891, CA448628, CB119078, DC404273
    Conserved Domains (1) summary
    pfam13553
    Location:101306
    FIIND; Function to find
  14. NM_001351791.2NP_001338720.1  caspase recruitment domain-containing protein 8 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF322184, AF511652, BC056891, CA448628, DA675182, DC382648, DC404273
    Conserved Domains (1) summary
    pfam13553
    Location:77282
    FIIND; Function to find
  15. NM_001351792.2NP_001338721.1  caspase recruitment domain-containing protein 8 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF322184, AF511652, BC056891, CA448628, DA675182, DC347384, DC404273
    Conserved Domains (1) summary
    pfam13553
    Location:77282
    FIIND; Function to find
  16. NM_001365950.1NP_001352879.1  caspase recruitment domain-containing protein 8 isoform k

    Status: REVIEWED

    Source sequence(s)
    AC008392, AC011466
    Conserved Domains (2) summary
    pfam00619
    Location:347429
    CARD; Caspase recruitment domain
    pfam13553
    Location:77330
    FIIND; Function to find
  17. NM_014959.5NP_055774.2  caspase recruitment domain-containing protein 8 isoform b

    See identical proteins and their annotated locations for NP_055774.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a. Variants 2, 3 and 11 encode the same isoform (b).
    Source sequence(s)
    AC011466, AF322184, AF511652, BC045539, BC056891, CA389350, CA448628, DC404273
    Consensus CDS
    CCDS12712.2
    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (2) summary
    pfam00619
    Location:403485
    CARD; Caspase recruitment domain
    pfam13553
    Location:132386
    FIIND; Function to find

RNA

  1. NR_033678.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC011466, AF322184, CA448628
    Related
    ENST00000518622.5
  2. NR_033679.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC011466, BC056891, CA448628, EU118121
  3. NR_033680.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC011466, AF511652, CA448628
  4. NR_147707.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF143869, AK302327, DC347384, DC404273

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    48203148..48256264 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026485.1XP_016881974.1  caspase recruitment domain-containing protein 8 isoform X6

  2. XM_011526650.2XP_011524952.1  caspase recruitment domain-containing protein 8 isoform X14

    See identical proteins and their annotated locations for XP_011524952.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (1) summary
    pfam13553
    Location:182387
    FIIND; Function to find
  3. XM_006723106.4XP_006723169.1  caspase recruitment domain-containing protein 8 isoform X14

    See identical proteins and their annotated locations for XP_006723169.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (1) summary
    pfam13553
    Location:182387
    FIIND; Function to find
  4. XM_017026492.2XP_016881981.1  caspase recruitment domain-containing protein 8 isoform X16

    Conserved Domains (1) summary
    pfam13553
    Location:132337
    FIIND; Function to find
  5. XM_006723097.4XP_006723160.1  caspase recruitment domain-containing protein 8 isoform X3

    See identical proteins and their annotated locations for XP_006723160.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Related
    ENSP00000427858.1, ENST00000521613.5
    Conserved Domains (2) summary
    pfam00619
    Location:403485
    CARD; Caspase recruitment domain
    pfam13553
    Location:132386
    FIIND; Function to find
  6. XM_024451421.1XP_024307189.1  caspase recruitment domain-containing protein 8 isoform X8

    Conserved Domains (2) summary
    pfam00619
    Location:372454
    CARD; Caspase recruitment domain
    pfam13553
    Location:101355
    FIIND; Function to find
  7. XM_017026498.1XP_016881987.1  caspase recruitment domain-containing protein 8 isoform X17

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (1) summary
    pfam13553
    Location:77281
    FIIND; Function to find
  8. XM_006723109.3XP_006723172.1  caspase recruitment domain-containing protein 8 isoform X17

    See identical proteins and their annotated locations for XP_006723172.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (1) summary
    pfam13553
    Location:77281
    FIIND; Function to find
  9. XM_006723104.3XP_006723167.1  caspase recruitment domain-containing protein 8 isoform X11

    See identical proteins and their annotated locations for XP_006723167.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    UniProtKB/TrEMBL
    A0A024QZD3
    Conserved Domains (2) summary
    pfam00619
    Location:347429
    CARD; Caspase recruitment domain
    pfam13553
    Location:77330
    FIIND; Function to find
  10. XM_006723098.3XP_006723161.1  caspase recruitment domain-containing protein 8 isoform X8

    See identical proteins and their annotated locations for XP_006723161.1

    Conserved Domains (2) summary
    pfam00619
    Location:372454
    CARD; Caspase recruitment domain
    pfam13553
    Location:101355
    FIIND; Function to find
  11. XM_006723107.3XP_006723170.1  caspase recruitment domain-containing protein 8 isoform X15

    See identical proteins and their annotated locations for XP_006723170.1

    Conserved Domains (1) summary
    pfam13553
    Location:182348
    FIIND; Function to find
  12. XM_017026499.1XP_016881988.1  caspase recruitment domain-containing protein 8 isoform X18

  13. XM_017026484.2XP_016881973.1  caspase recruitment domain-containing protein 8 isoform X4

  14. XM_017026482.2XP_016881971.1  caspase recruitment domain-containing protein 8 isoform X2

    Conserved Domains (2) summary
    pfam00619
    Location:452534
    CARD; Caspase recruitment domain
    pfam13553
    Location:182435
    FIIND; Function to find
  15. XM_024451422.1XP_024307190.1  caspase recruitment domain-containing protein 8 isoform X9

    Conserved Domains (2) summary
    pfam00619
    Location:371453
    CARD; Caspase recruitment domain
    pfam13553
    Location:101354
    FIIND; Function to find
  16. XM_011526648.3XP_011524950.1  caspase recruitment domain-containing protein 8 isoform X7

    Conserved Domains (2) summary
    pfam00619
    Location:379461
    CARD; Caspase recruitment domain
    pfam13553
    Location:109362
    FIIND; Function to find
  17. XM_006723094.4XP_006723157.1  caspase recruitment domain-containing protein 8 isoform X2

    Conserved Domains (2) summary
    pfam00619
    Location:452534
    CARD; Caspase recruitment domain
    pfam13553
    Location:182435
    FIIND; Function to find
  18. XM_017026483.2XP_016881972.1  caspase recruitment domain-containing protein 8 isoform X3

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (2) summary
    pfam00619
    Location:403485
    CARD; Caspase recruitment domain
    pfam13553
    Location:132386
    FIIND; Function to find
  19. XM_006723096.4XP_006723159.1  caspase recruitment domain-containing protein 8 isoform X3

    See identical proteins and their annotated locations for XP_006723159.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Related
    ENSP00000428736.1, ENST00000520153.5
    Conserved Domains (2) summary
    pfam00619
    Location:403485
    CARD; Caspase recruitment domain
    pfam13553
    Location:132386
    FIIND; Function to find
  20. XM_011526643.3XP_011524945.1  caspase recruitment domain-containing protein 8 isoform X1

    See identical proteins and their annotated locations for XP_011524945.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (2) summary
    pfam00619
    Location:453535
    CARD; Caspase recruitment domain
    pfam13553
    Location:182436
    FIIND; Function to find
  21. XM_006723092.4XP_006723155.1  caspase recruitment domain-containing protein 8 isoform X1

    See identical proteins and their annotated locations for XP_006723155.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (2) summary
    pfam00619
    Location:453535
    CARD; Caspase recruitment domain
    pfam13553
    Location:182436
    FIIND; Function to find
  22. XM_011526641.3XP_011524943.1  caspase recruitment domain-containing protein 8 isoform X1

    See identical proteins and their annotated locations for XP_011524943.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (2) summary
    pfam00619
    Location:453535
    CARD; Caspase recruitment domain
    pfam13553
    Location:182436
    FIIND; Function to find
  23. XM_006723093.4XP_006723156.1  caspase recruitment domain-containing protein 8 isoform X1

    See identical proteins and their annotated locations for XP_006723156.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (2) summary
    pfam00619
    Location:453535
    CARD; Caspase recruitment domain
    pfam13553
    Location:182436
    FIIND; Function to find
  24. XM_011526647.3XP_011524949.1  caspase recruitment domain-containing protein 8 isoform X5

    See identical proteins and their annotated locations for XP_011524949.1

    Conserved Domains (2) summary
    pfam00619
    Location:380462
    CARD; Caspase recruitment domain
    pfam13553
    Location:109363
    FIIND; Function to find
  25. XM_011526646.3XP_011524948.1  caspase recruitment domain-containing protein 8 isoform X5

    See identical proteins and their annotated locations for XP_011524948.1

    Conserved Domains (2) summary
    pfam00619
    Location:380462
    CARD; Caspase recruitment domain
    pfam13553
    Location:109363
    FIIND; Function to find
  26. XM_017026488.2XP_016881977.1  caspase recruitment domain-containing protein 8 isoform X13

    Conserved Domains (2) summary
    pfam00619
    Location:341423
    CARD; Caspase recruitment domain
    pfam13553
    Location:70324
    FIIND; Function to find
  27. XM_024451423.1XP_024307191.1  caspase recruitment domain-containing protein 8 isoform X10

    Conserved Domains (2) summary
    pfam00619
    Location:348430
    CARD; Caspase recruitment domain
    pfam13553
    Location:77331
    FIIND; Function to find
  28. XM_024451425.1XP_024307193.1  caspase recruitment domain-containing protein 8 isoform X12

    Conserved Domains (2) summary
    pfam00619
    Location:343425
    CARD; Caspase recruitment domain
    pfam13553
    Location:72326
    FIIND; Function to find
  29. XM_006723102.4XP_006723165.1  caspase recruitment domain-containing protein 8 isoform X10

    See identical proteins and their annotated locations for XP_006723165.1

    Conserved Domains (2) summary
    pfam00619
    Location:348430
    CARD; Caspase recruitment domain
    pfam13553
    Location:77331
    FIIND; Function to find
  30. XM_006723091.4XP_006723154.1  caspase recruitment domain-containing protein 8 isoform X1

    See identical proteins and their annotated locations for XP_006723154.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (2) summary
    pfam00619
    Location:453535
    CARD; Caspase recruitment domain
    pfam13553
    Location:182436
    FIIND; Function to find
  31. XM_024451424.1XP_024307192.1  caspase recruitment domain-containing protein 8 isoform X12

    Conserved Domains (2) summary
    pfam00619
    Location:343425
    CARD; Caspase recruitment domain
    pfam13553
    Location:72326
    FIIND; Function to find
  32. XM_011526644.3XP_011524946.1  caspase recruitment domain-containing protein 8 isoform X1

    See identical proteins and their annotated locations for XP_011524946.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (2) summary
    pfam00619
    Location:453535
    CARD; Caspase recruitment domain
    pfam13553
    Location:182436
    FIIND; Function to find
  33. XM_017026487.2XP_016881976.1  caspase recruitment domain-containing protein 8 isoform X13

    Conserved Domains (2) summary
    pfam00619
    Location:341423
    CARD; Caspase recruitment domain
    pfam13553
    Location:70324
    FIIND; Function to find
  34. XM_006723110.3XP_006723173.1  caspase recruitment domain-containing protein 8 isoform X19

    See identical proteins and their annotated locations for XP_006723173.1

    UniProtKB/TrEMBL
    E5RFV9
    Related
    ENSP00000427727.1, ENST00000520007.5

RNA

  1. XR_001753637.2 RNA Sequence

  2. XR_001753636.1 RNA Sequence

  3. XR_430193.3 RNA Sequence

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