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CARD8 caspase recruitment domain family member 8 [ Homo sapiens (human) ]

Gene ID: 22900, updated on 2-Mar-2021

Summary

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Official Symbol
CARD8provided by HGNC
Official Full Name
caspase recruitment domain family member 8provided by HGNC
Primary source
HGNC:HGNC:17057
See related
Ensembl:ENSG00000105483 MIM:609051
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NDPP; DACAR; DAKAR; NDPP1; TUCAN; CARDINAL
Summary
The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
Expression
Broad expression in spleen (RPKM 13.6), lymph node (RPKM 11.5) and 24 other tissues See more
Orthologs
all
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Genomic context

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See CARD8 in Genome Data Viewer
Location:
19q13.33
Exon count:
21
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (48203148..48256264, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48706405..48759203, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene DNA ligase 1 Neighboring gene uncharacterized LOC107985293 Neighboring gene zinc finger SWIM-type containing 9 Neighboring gene CARD8 antisense RNA 1 Neighboring gene vomeronasal 1 receptor 97 pseudogene Neighboring gene ZNF114 antisense RNA 1 Neighboring gene zinc finger protein 114 Neighboring gene outer dynein arm docking complex subunit 1 Neighboring gene Sharpr-MPRA regulatory region 73

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genetic variation in CARD8, a gene coding for an NLRP3 inflammasome-associated protein, alters the genetic risk for diabetic nephropathy in the context of type 2 diabetes mellitus. Tsetsos F, et al. Diab Vasc Dis Res, 2020 Nov-Dec. PMID 33164551, Free PMC Article
  2. CARD8 polymorphism rs2043211 protects against noise-induced hearing loss by causing the dysfunction of CARD8 protein. Miao L, et al. Environ Sci Pollut Res Int, 2021 Feb. PMID 33067783
  3. A New Risk Polymorphism rs10403848 of CARD8 Significantly Associated with Psoriasis Vulgaris in Northeastern China. Yu P, et al. Biomed Res Int, 2020. PMID 32104685, Free PMC Article
  4. Relationship of CARD8 Gene Polymorphisms with Susceptibility to Ankylosing Spondylitis: A Case-Control Study. Xu H, et al. Med Sci Monit, 2020 Feb 21. PMID 32080163, Free PMC Article
  5. Association between caspase recruitment domain-containing protein 8 rs2043211 polymorphism and cardiovascular disease susceptibility: A systematic review and meta-analysis. Huang H, et al. Anatol J Cardiol, 2018 Aug. PMID 30088494, Free PMC Article

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CARD8 polymorphism rs2043211 protects against noise-induced hearing loss by causing the dysfunction of CARD8 protein.
    Title: CARD8 polymorphism rs2043211 protects against noise-induced hearing loss by causing the dysfunction of CARD8 protein.
  2. Genetic variation in CARD8, a gene coding for an NLRP3 inflammasome-associated protein, alters the genetic risk for diabetic nephropathy in the context of type 2 diabetes mellitus.
    Title: Genetic variation in <i>CARD8</i>, a gene coding for an NLRP3 inflammasome-associated protein, alters the genetic risk for diabetic nephropathy in the context of type 2 diabetes mellitus.
  3. Association of CARD8 Activating Polymorphism With Bone Erosion in Cholesteatoma Patients.
    Title: Association of CARD8 Activating Polymorphism With Bone Erosion in Cholesteatoma Patients.
  4. Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.
    Title: Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.
  5. Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8.
    Title: Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8.
  6. Relationship of CARD8 Gene Polymorphisms with Susceptibility to Ankylosing Spondylitis: A Case-Control Study.
    Title: Relationship of CARD8 Gene Polymorphisms with Susceptibility to Ankylosing Spondylitis: A Case-Control Study.
  7. A New Risk Polymorphism rs10403848 of CARD8 Significantly Associated with Psoriasis Vulgaris in Northeastern China.
    Title: A New Risk Polymorphism rs10403848 of CARD8 Significantly Associated with Psoriasis Vulgaris in Northeastern China.
  8. Combined polymorphisms in genes encoding the inflammasome components NLRP3 and CARD8 confer risk of ischemic stroke in men.
    Title: Combined polymorphisms in genes encoding the inflammasome components NLRP3 and CARD8 confer risk of ischemic stroke in men.
  9. Polymorphisms in CARD8 and NLRP3 are associated with extrapulmonary TB and poor clinical outcome in active TB in Ethiopia.
    Title: Polymorphisms in CARD8 and NLRP3 are associated with extrapulmonary TB and poor clinical outcome in active TB in Ethiopia.
  10. Patients with combined wild type of both NLRP3 rs35829419 and CARD8 rs2043211 had significantly smaller odds for early implant loosening (odds ratio 0.33, p = 0.02).
    Title: Association of NLRP3 and CARD8 Inflammasome Polymorphisms With Aseptic Loosening After Primary Total Hip Arthroplasty.
Submit: New GeneRIF Correction See all GeneRIFs (69)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Inflammatory bowel disease 30
MedGen: CN293414 OMIM: 619079 GeneReviews: Not available
not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ18119, FLJ18121, KIAA0955, MGC57162, DKFZp779L0366

Gene Ontology Provided by GOA

Function Evidence Code Pubs
CARD domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
NACHT domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
cysteine-type endopeptidase activator activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
cysteine-type endopeptidase activator activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
activation of cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
  
inhibition of cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
 PubMed 
negative regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
negative regulation of interleukin-1 beta production IDA
Inferred from Direct Assay
more info
 PubMed 
negative regulation of lipopolysaccharide-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
negative regulation of tumor necrosis factor-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
positive regulation of interleukin-1 beta production IDA
Inferred from Direct Assay
more info
 PubMed 
regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
NLRP3 inflammasome complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
NLRP3 inflammasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
cytosol TAS
Traceable Author Statement
more info
  
inflammasome complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
  
nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
caspase recruitment domain-containing protein 8
Names
CARD inhibitor of NF-kappaB-activating ligands
apoptotic protein NDPP1
tumor up-regulated CARD-containing antagonist of CASP9
tumor up-regulated CARD-containing antagonist of caspase nine

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029574.2 RefSeqGene

    Range
    5358..53184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184900.3 → NP_001171829.1  caspase recruitment domain-containing protein 8 isoform a

    See identical proteins and their annotated locations for NP_001171829.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a, also referred to as T60). Variants 1 and 10 encode the same protein (isoform a).
    Source sequence(s)
    AC011466, BC056891, CA448628, CB119078, DC404273, EU118120
    Consensus CDS
    CCDS54289.1
    UniProtKB/Swiss-Prot
    Q9Y2G2
    Related
    ENSP00000499211.1, ENST00000651546.1
    Conserved Domains (2) summary
    pfam00619
    Location:453 → 535
    CARD; Caspase recruitment domain
    pfam13553
    Location:182 → 436
    FIIND; Function to find

  2. NM_001184901.1 → NP_001171830.1  caspase recruitment domain-containing protein 8 isoform b

    See identical proteins and their annotated locations for NP_001171830.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a. Variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AC011466, AK297045, AK297069, BC046136, CA448628
    Consensus CDS
    CCDS12712.2
    UniProtKB/Swiss-Prot
    Q9Y2G2
    Related
    ENSP00000391248.2, ENST00000447740.6
    Conserved Domains (2) summary
    pfam00619
    Location:403 → 485
    CARD; Caspase recruitment domain
    pfam13553
    Location:132 → 386
    FIIND; Function to find

  3. NM_001184902.2 → NP_001171831.1  caspase recruitment domain-containing protein 8 isoform c

    See identical proteins and their annotated locations for NP_001171831.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate exon in the 3' coding region, which results in a frameshift compared to variant 1. This results in a shorter protein (isoform c), compared to isoform a. Variants 4 and 5 encode the same isoform (c).
    Source sequence(s)
    AC011466, AF322184, AF511652, BC056891, CA448628, CB119078, DC404273
    Consensus CDS
    CCDS54288.1
    UniProtKB/Swiss-Prot
    Q9Y2G2
    Related
    ENSP00000429839.1, ENST00000520753.5
    Conserved Domains (1) summary
    pfam13553
    Location:182 → 387
    FIIND; Function to find

  4. NM_001184903.1 → NP_001171832.1  caspase recruitment domain-containing protein 8 isoform c

    See identical proteins and their annotated locations for NP_001171832.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate exon in the 3' coding region, which results in a frameshift compared to variant 1. This results in a shorter protein (isoform c), compared to isoform a. Variants 4 and 5 encode the same isoform (c).
    Source sequence(s)
    AC011466, AF322184, AK297045, BC046136, CA448628
    Consensus CDS
    CCDS54288.1
    UniProtKB/Swiss-Prot
    Q9Y2G2
    Related
    ENSP00000430747.1, ENST00000520015.5
    Conserved Domains (1) summary
    pfam13553
    Location:182 → 387
    FIIND; Function to find

  5. NM_001184904.2 → NP_001171833.1  caspase recruitment domain-containing protein 8 isoform d

    See identical proteins and their annotated locations for NP_001171833.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, 3' coding region, and 3' UTR compared to variant 1. The resulting isoform (d) is shorter than isoform a.
    Source sequence(s)
    AC011466, AI040349, BC046136, DC404273
    Consensus CDS
    CCDS54287.1
    UniProtKB/TrEMBL
    E5RFV9
    Related
    ENSP00000430108.1, ENST00000519332.5

  6. NM_001351782.2 → NP_001338711.1  caspase recruitment domain-containing protein 8 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1 and 10 encode the same protein (isoform a).
    Source sequence(s)
    AC011466, BC056891, CA448628, CB119078, DC404273, EU118120
    Consensus CDS
    CCDS54289.1
    Related
    ENSP00000428883.1, ENST00000519940.6
    Conserved Domains (2) summary
    pfam00619
    Location:453 → 535
    CARD; Caspase recruitment domain
    pfam13553
    Location:182 → 436
    FIIND; Function to find

  7. NM_001351783.2 → NP_001338712.1  caspase recruitment domain-containing protein 8 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC008392, AC011466, AF322184, AF511652, BC045539, BC056891, CA389350, CA448628, DC404273
    Consensus CDS
    CCDS12712.2
    Conserved Domains (2) summary
    pfam00619
    Location:403 → 485
    CARD; Caspase recruitment domain
    pfam13553
    Location:132 → 386
    FIIND; Function to find

  8. NM_001351784.2 → NP_001338713.1  caspase recruitment domain-containing protein 8 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF322184, AF511652, BC056891, CA448628, CR983845, DC347384, DC382648, DC404273
    Conserved Domains (2) summary
    pfam00619
    Location:348 → 430
    CARD; Caspase recruitment domain
    pfam13553
    Location:77 → 331
    FIIND; Function to find

  9. NM_001351786.2 → NP_001338715.1  caspase recruitment domain-containing protein 8 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF322184, AF511652, BC056891, CA448628, CR983845, DC382648, DC404273
    Conserved Domains (2) summary
    pfam00619
    Location:341 → 423
    CARD; Caspase recruitment domain
    pfam13553
    Location:70 → 324
    FIIND; Function to find

  10. NM_001351787.2 → NP_001338716.1  caspase recruitment domain-containing protein 8 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF143869, AK302327, DC382648, DC404273
    Conserved Domains (1) summary
    pfam13553
    Location:77 → 331
    FIIND; Function to find

  11. NM_001351788.2 → NP_001338717.1  caspase recruitment domain-containing protein 8 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF322184, AF511652, BC056891, CA448628, DC382648, DC404273
    Conserved Domains (1) summary
    pfam13553
    Location:132 → 337
    FIIND; Function to find

  12. NM_001351789.2 → NP_001338718.1  caspase recruitment domain-containing protein 8 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF322184, AF511652, BC056891, CA448628, DC382648, DC404273
    Conserved Domains (1) summary
    pfam13553
    Location:132 → 337
    FIIND; Function to find

  13. NM_001351790.2 → NP_001338719.1  caspase recruitment domain-containing protein 8 isoform i

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF322184, AF511652, BC056891, CA448628, CB119078, DC404273
    Conserved Domains (1) summary
    pfam13553
    Location:101 → 306
    FIIND; Function to find

  14. NM_001351791.2 → NP_001338720.1  caspase recruitment domain-containing protein 8 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF322184, AF511652, BC056891, CA448628, DA675182, DC382648, DC404273
    Conserved Domains (1) summary
    pfam13553
    Location:77 → 282
    FIIND; Function to find

  15. NM_001351792.2 → NP_001338721.1  caspase recruitment domain-containing protein 8 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF322184, AF511652, BC056891, CA448628, DA675182, DC347384, DC404273
    Conserved Domains (1) summary
    pfam13553
    Location:77 → 282
    FIIND; Function to find

  16. NM_001365950.1 → NP_001352879.1  caspase recruitment domain-containing protein 8 isoform k

    Status: REVIEWED

    Source sequence(s)
    AC008392, AC011466
    Conserved Domains (2) summary
    pfam00619
    Location:347 → 429
    CARD; Caspase recruitment domain
    pfam13553
    Location:77 → 330
    FIIND; Function to find

  17. NM_014959.5 → NP_055774.2  caspase recruitment domain-containing protein 8 isoform b

    See identical proteins and their annotated locations for NP_055774.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a. Variants 2, 3 and 11 encode the same isoform (b).
    Source sequence(s)
    AC011466, AF322184, AF511652, BC045539, BC056891, CA389350, CA448628, DC404273
    Consensus CDS
    CCDS12712.2
    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (2) summary
    pfam00619
    Location:403 → 485
    CARD; Caspase recruitment domain
    pfam13553
    Location:132 → 386
    FIIND; Function to find

RNA

  1. NR_033678.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC011466, AF322184, CA448628
    Related
    ENST00000518622.5

  2. NR_033679.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC011466, BC056891, CA448628, EU118121

  3. NR_033680.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC011466, AF511652, CA448628

  4. NR_147707.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF143869, AK302327, DC347384, DC404273

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    48203148..48256264 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026485.1 → XP_016881974.1  caspase recruitment domain-containing protein 8 isoform X6

  2. XM_011526650.2 → XP_011524952.1  caspase recruitment domain-containing protein 8 isoform X14

    See identical proteins and their annotated locations for XP_011524952.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (1) summary
    pfam13553
    Location:182 → 387
    FIIND; Function to find

  3. XM_006723106.4 → XP_006723169.1  caspase recruitment domain-containing protein 8 isoform X14

    See identical proteins and their annotated locations for XP_006723169.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (1) summary
    pfam13553
    Location:182 → 387
    FIIND; Function to find

  4. XM_017026492.2 → XP_016881981.1  caspase recruitment domain-containing protein 8 isoform X16

    Conserved Domains (1) summary
    pfam13553
    Location:132 → 337
    FIIND; Function to find

  5. XM_006723097.4 → XP_006723160.1  caspase recruitment domain-containing protein 8 isoform X3

    See identical proteins and their annotated locations for XP_006723160.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Related
    ENSP00000427858.1, ENST00000521613.5
    Conserved Domains (2) summary
    pfam00619
    Location:403 → 485
    CARD; Caspase recruitment domain
    pfam13553
    Location:132 → 386
    FIIND; Function to find

  6. XM_024451421.1 → XP_024307189.1  caspase recruitment domain-containing protein 8 isoform X8

    Conserved Domains (2) summary
    pfam00619
    Location:372 → 454
    CARD; Caspase recruitment domain
    pfam13553
    Location:101 → 355
    FIIND; Function to find

  7. XM_017026498.1 → XP_016881987.1  caspase recruitment domain-containing protein 8 isoform X17

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (1) summary
    pfam13553
    Location:77 → 281
    FIIND; Function to find

  8. XM_006723109.3 → XP_006723172.1  caspase recruitment domain-containing protein 8 isoform X17

    See identical proteins and their annotated locations for XP_006723172.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (1) summary
    pfam13553
    Location:77 → 281
    FIIND; Function to find

  9. XM_006723104.3 → XP_006723167.1  caspase recruitment domain-containing protein 8 isoform X11

    See identical proteins and their annotated locations for XP_006723167.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    UniProtKB/TrEMBL
    A0A024QZD3
    Conserved Domains (2) summary
    pfam00619
    Location:347 → 429
    CARD; Caspase recruitment domain
    pfam13553
    Location:77 → 330
    FIIND; Function to find

  10. XM_006723098.3 → XP_006723161.1  caspase recruitment domain-containing protein 8 isoform X8

    See identical proteins and their annotated locations for XP_006723161.1

    Conserved Domains (2) summary
    pfam00619
    Location:372 → 454
    CARD; Caspase recruitment domain
    pfam13553
    Location:101 → 355
    FIIND; Function to find

  11. XM_006723107.3 → XP_006723170.1  caspase recruitment domain-containing protein 8 isoform X15

    See identical proteins and their annotated locations for XP_006723170.1

    Conserved Domains (1) summary
    pfam13553
    Location:182 → 348
    FIIND; Function to find

  12. XM_017026499.1 → XP_016881988.1  caspase recruitment domain-containing protein 8 isoform X18

  13. XM_017026484.2 → XP_016881973.1  caspase recruitment domain-containing protein 8 isoform X4

  14. XM_017026482.2 → XP_016881971.1  caspase recruitment domain-containing protein 8 isoform X2

    Conserved Domains (2) summary
    pfam00619
    Location:452 → 534
    CARD; Caspase recruitment domain
    pfam13553
    Location:182 → 435
    FIIND; Function to find

  15. XM_024451422.1 → XP_024307190.1  caspase recruitment domain-containing protein 8 isoform X9

    Conserved Domains (2) summary
    pfam00619
    Location:371 → 453
    CARD; Caspase recruitment domain
    pfam13553
    Location:101 → 354
    FIIND; Function to find

  16. XM_011526648.3 → XP_011524950.1  caspase recruitment domain-containing protein 8 isoform X7

    Conserved Domains (2) summary
    pfam00619
    Location:379 → 461
    CARD; Caspase recruitment domain
    pfam13553
    Location:109 → 362
    FIIND; Function to find

  17. XM_006723094.4 → XP_006723157.1  caspase recruitment domain-containing protein 8 isoform X2

    Conserved Domains (2) summary
    pfam00619
    Location:452 → 534
    CARD; Caspase recruitment domain
    pfam13553
    Location:182 → 435
    FIIND; Function to find

  18. XM_017026483.2 → XP_016881972.1  caspase recruitment domain-containing protein 8 isoform X3

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (2) summary
    pfam00619
    Location:403 → 485
    CARD; Caspase recruitment domain
    pfam13553
    Location:132 → 386
    FIIND; Function to find

  19. XM_006723096.4 → XP_006723159.1  caspase recruitment domain-containing protein 8 isoform X3

    See identical proteins and their annotated locations for XP_006723159.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Related
    ENSP00000428736.1, ENST00000520153.5
    Conserved Domains (2) summary
    pfam00619
    Location:403 → 485
    CARD; Caspase recruitment domain
    pfam13553
    Location:132 → 386
    FIIND; Function to find

  20. XM_011526643.3 → XP_011524945.1  caspase recruitment domain-containing protein 8 isoform X1

    See identical proteins and their annotated locations for XP_011524945.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (2) summary
    pfam00619
    Location:453 → 535
    CARD; Caspase recruitment domain
    pfam13553
    Location:182 → 436
    FIIND; Function to find

  21. XM_006723092.4 → XP_006723155.1  caspase recruitment domain-containing protein 8 isoform X1

    See identical proteins and their annotated locations for XP_006723155.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (2) summary
    pfam00619
    Location:453 → 535
    CARD; Caspase recruitment domain
    pfam13553
    Location:182 → 436
    FIIND; Function to find

  22. XM_011526641.3 → XP_011524943.1  caspase recruitment domain-containing protein 8 isoform X1

    See identical proteins and their annotated locations for XP_011524943.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (2) summary
    pfam00619
    Location:453 → 535
    CARD; Caspase recruitment domain
    pfam13553
    Location:182 → 436
    FIIND; Function to find

  23. XM_006723093.4 → XP_006723156.1  caspase recruitment domain-containing protein 8 isoform X1

    See identical proteins and their annotated locations for XP_006723156.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (2) summary
    pfam00619
    Location:453 → 535
    CARD; Caspase recruitment domain
    pfam13553
    Location:182 → 436
    FIIND; Function to find

  24. XM_011526647.3 → XP_011524949.1  caspase recruitment domain-containing protein 8 isoform X5

    See identical proteins and their annotated locations for XP_011524949.1

    Conserved Domains (2) summary
    pfam00619
    Location:380 → 462
    CARD; Caspase recruitment domain
    pfam13553
    Location:109 → 363
    FIIND; Function to find

  25. XM_011526646.3 → XP_011524948.1  caspase recruitment domain-containing protein 8 isoform X5

    See identical proteins and their annotated locations for XP_011524948.1

    Conserved Domains (2) summary
    pfam00619
    Location:380 → 462
    CARD; Caspase recruitment domain
    pfam13553
    Location:109 → 363
    FIIND; Function to find

  26. XM_017026488.2 → XP_016881977.1  caspase recruitment domain-containing protein 8 isoform X13

    Conserved Domains (2) summary
    pfam00619
    Location:341 → 423
    CARD; Caspase recruitment domain
    pfam13553
    Location:70 → 324
    FIIND; Function to find

  27. XM_024451423.1 → XP_024307191.1  caspase recruitment domain-containing protein 8 isoform X10

    Conserved Domains (2) summary
    pfam00619
    Location:348 → 430
    CARD; Caspase recruitment domain
    pfam13553
    Location:77 → 331
    FIIND; Function to find

  28. XM_024451425.1 → XP_024307193.1  caspase recruitment domain-containing protein 8 isoform X12

    Conserved Domains (2) summary
    pfam00619
    Location:343 → 425
    CARD; Caspase recruitment domain
    pfam13553
    Location:72 → 326
    FIIND; Function to find

  29. XM_006723102.4 → XP_006723165.1  caspase recruitment domain-containing protein 8 isoform X10

    See identical proteins and their annotated locations for XP_006723165.1

    Conserved Domains (2) summary
    pfam00619
    Location:348 → 430
    CARD; Caspase recruitment domain
    pfam13553
    Location:77 → 331
    FIIND; Function to find

  30. XM_006723091.4 → XP_006723154.1  caspase recruitment domain-containing protein 8 isoform X1

    See identical proteins and their annotated locations for XP_006723154.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (2) summary
    pfam00619
    Location:453 → 535
    CARD; Caspase recruitment domain
    pfam13553
    Location:182 → 436
    FIIND; Function to find

  31. XM_024451424.1 → XP_024307192.1  caspase recruitment domain-containing protein 8 isoform X12

    Related
    ENST00000522051.5
    Conserved Domains (2) summary
    pfam00619
    Location:343 → 425
    CARD; Caspase recruitment domain
    pfam13553
    Location:72 → 326
    FIIND; Function to find

  32. XM_011526644.3 → XP_011524946.1  caspase recruitment domain-containing protein 8 isoform X1

    See identical proteins and their annotated locations for XP_011524946.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (2) summary
    pfam00619
    Location:453 → 535
    CARD; Caspase recruitment domain
    pfam13553
    Location:182 → 436
    FIIND; Function to find

  33. XM_017026487.2 → XP_016881976.1  caspase recruitment domain-containing protein 8 isoform X13

    Conserved Domains (2) summary
    pfam00619
    Location:341 → 423
    CARD; Caspase recruitment domain
    pfam13553
    Location:70 → 324
    FIIND; Function to find

  34. XM_006723110.3 → XP_006723173.1  caspase recruitment domain-containing protein 8 isoform X19

    See identical proteins and their annotated locations for XP_006723173.1

    UniProtKB/TrEMBL
    E5RFV9
    Related
    ENSP00000427727.1, ENST00000520007.5

RNA

  1. XR_001753637.2 RNA Sequence

  2. XR_001753636.1 RNA Sequence

  3. XR_430193.3 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y2G2.1 GenPept UniProtKB/Swiss-Prot:Q9Y2G2

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