CARD8 caspase recruitment domain family member 8 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CARD8provided by HGNC
Official Full Name: caspase recruitment domain family member 8provided by HGNC
Primary source: HGNC:HGNC:17057
See related: Ensembl:ENSG00000105483 MIM:609051; AllianceGenome:HGNC:17057
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NDPP; DACAR; DAKAR; NDPP1; TUCAN; CARDINAL
Summary: The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
Expression: Broad expression in spleen (RPKM 13.6), lymph node (RPKM 11.5) and 24 other tissues See more
Orthologs: all
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Genomic context

Location:: 19q13.33

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
110	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (48179825..48255946, complement)
110	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (51197212..51250053, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (48706405..48759203, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A ubiquitin-independent proteasome pathway controls activation of the CARD8 inflammasome.
Title: A ubiquitin-independent proteasome pathway controls activation of the CARD8 inflammasome.
SNP rs2043211 (p.C10X) in CARD8 Is Associated with Large-Artery Atherosclerosis Stroke in a Chinese Population.
Title: SNP rs2043211 (p.C10X) in CARD8 Is Associated with Large-Artery Atherosclerosis Stroke in a Chinese Population.
Associations of NLRP3 and CARD8 gene polymorphisms with alcohol dependence and commonly related psychiatric disorders: a preliminary study.
Title: Associations of NLRP3 and CARD8 gene polymorphisms with alcohol dependence and commonly related psychiatric disorders: a preliminary study.
Activation of the CARD8 Inflammasome Requires a Disordered Region.
Title: Activation of the CARD8 Inflammasome Requires a Disordered Region.
Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment.
Title: Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment.
CARD8 inflammasome activation triggers pyroptosis in human T cells.
Title: CARD8 inflammasome activation triggers pyroptosis in human T cells.
CARD8 is an inflammasome sensor for HIV-1 protease activity.
Title: CARD8 is an inflammasome sensor for HIV-1 protease activity.
Expression of CARD8 in human atherosclerosis and its regulation of inflammatory proteins in human endothelial cells.
Title: Expression of CARD8 in human atherosclerosis and its regulation of inflammatory proteins in human endothelial cells.
CARD8 polymorphism rs2043211 protects against noise-induced hearing loss by causing the dysfunction of CARD8 protein.
Title: CARD8 polymorphism rs2043211 protects against noise-induced hearing loss by causing the dysfunction of CARD8 protein.
Genetic variation in CARD8, a gene coding for an NLRP3 inflammasome-associated protein, alters the genetic risk for diabetic nephropathy in the context of type 2 diabetes mellitus.
Title: Genetic variation in CARD8, a gene coding for an NLRP3 inflammasome-associated protein, alters the genetic risk for diabetic nephropathy in the context of type 2 diabetes mellitus.

Submit: New GeneRIF Correction See all GeneRIFs (77)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Inflammatory bowel disease 30 MedGen: C5436750 OMIM: 619079 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:434012 (e-PCR)
- UniSTS:157204

WI-14251 (e-PCR)
- UniSTS:25877

GDB:312794 (e-PCR)
- UniSTS:30247

SHGC-33567 (e-PCR)
- UniSTS:35151

D19S1113 (e-PCR)
- UniSTS:81764

D19S1010 (e-PCR)
- UniSTS:81765

RH16607 (e-PCR)
- UniSTS:16242

RH36905 (e-PCR)
- UniSTS:87932

Homology

Orthologs from Annotation Pipeline: 134 organisms have orthologs with human gene CARD8
Orthologs

Clone Names

FLJ18119, FLJ18121, KIAA0955, MGC57162, DKFZp779L0366

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables CARD domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables NACHT domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables cysteine-type endopeptidase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase activator activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables cysteine-type endopeptidase activator activity involved in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
enables pattern recognition receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in antiviral innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in inhibition of cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of NLRP3 inflammasome complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of interleukin-1 beta production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of lipopolysaccharide-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-1 beta production	IDA Inferred from Direct Assay more info	PubMed
involved_in programmed cell death	IEA Inferred from Electronic Annotation more info
involved_in regulation of I-kappaB kinase/NF-kappaB signaling	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in self proteolysis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of NLRP3 inflammasome complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of NLRP3 inflammasome complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: caspase recruitment domain-containing protein 8

Names: CARD inhibitor of NF-kappaB-activating ligands; apoptotic protein NDPP1; tumor up-regulated CARD-containing antagonist of CASP9; tumor up-regulated CARD-containing antagonist of caspase nine

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029574.3 RefSeqGene

Range

5034..52860

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184900.3 → NP_001171829.1 caspase recruitment domain-containing protein 8 isoform a

See identical proteins and their annotated locations for NP_001171829.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a, also referred to as T60). Variants 1 and 10 encode the same protein (isoform a).

Source sequence(s)

AC011466, BC056891, CA448628, CB119078, DC404273, EU118120

Consensus CDS

CCDS54289.1

UniProtKB/Swiss-Prot

Q96P82, Q9Y2G2

Related

ENSP00000499211.1, ENST00000651546.1

Conserved Domains (2) summary

pfam00619
Location:453 → 535

CARD; Caspase recruitment domain

pfam13553
Location:182 → 436

FIIND; Function to find
NM_001184901.1 → NP_001171830.1 caspase recruitment domain-containing protein 8 isoform b

See identical proteins and their annotated locations for NP_001171830.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a. Variants 2 and 3 encode the same isoform (b).

Source sequence(s)

AC011466, AK297045, AK297069, BC046136, CA448628

Consensus CDS

CCDS12712.2

UniProtKB/Swiss-Prot

Q9Y2G2

Related

ENSP00000391248.2, ENST00000447740.6

Conserved Domains (2) summary

pfam00619
Location:403 → 485

CARD; Caspase recruitment domain

pfam13553
Location:132 → 386

FIIND; Function to find
NM_001184902.2 → NP_001171831.1 caspase recruitment domain-containing protein 8 isoform c

See identical proteins and their annotated locations for NP_001171831.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate exon in the 3' coding region, which results in a frameshift compared to variant 1. This results in a shorter protein (isoform c), compared to isoform a. Variants 4 and 5 encode the same isoform (c).

Source sequence(s)

AC011466, AF322184, AF511652, BC056891, CA448628, CB119078, DC404273

Consensus CDS

CCDS54288.1

UniProtKB/Swiss-Prot

Q9Y2G2

Related

ENSP00000429839.1, ENST00000520753.5

Conserved Domains (1) summary

pfam13553
Location:182 → 387

FIIND; Function to find
NM_001184903.1 → NP_001171832.1 caspase recruitment domain-containing protein 8 isoform c

See identical proteins and their annotated locations for NP_001171832.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate exon in the 3' coding region, which results in a frameshift compared to variant 1. This results in a shorter protein (isoform c), compared to isoform a. Variants 4 and 5 encode the same isoform (c).

Source sequence(s)

AC011466, AF322184, AK297045, BC046136, CA448628

Consensus CDS

CCDS54288.1

UniProtKB/Swiss-Prot

Q9Y2G2

Related

ENSP00000430747.1, ENST00000520015.5

Conserved Domains (1) summary

pfam13553
Location:182 → 387

FIIND; Function to find
NM_001184904.2 → NP_001171833.1 caspase recruitment domain-containing protein 8 isoform d

See identical proteins and their annotated locations for NP_001171833.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR, 3' coding region, and 3' UTR compared to variant 1. The resulting isoform (d) is shorter than isoform a.

Source sequence(s)

AC011466, AI040349, BC046136, DC404273

Consensus CDS

CCDS54287.1

UniProtKB/TrEMBL

E5RFV9

Related

ENSP00000430108.1, ENST00000519332.5
NM_001351782.2 → NP_001338711.1 caspase recruitment domain-containing protein 8 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1 and 10 encode the same protein (isoform a).

Source sequence(s)

AC011466, BC056891, CA448628, CB119078, DC404273, EU118120

Consensus CDS

CCDS54289.1

UniProtKB/Swiss-Prot

Q96P82

Related

ENSP00000428883.1, ENST00000519940.6

Conserved Domains (2) summary

pfam00619
Location:453 → 535

CARD; Caspase recruitment domain

pfam13553
Location:182 → 436

FIIND; Function to find
NM_001351783.2 → NP_001338712.1 caspase recruitment domain-containing protein 8 isoform b

Status: REVIEWED

Source sequence(s)

AC008392, AC011466, AF322184, AF511652, BC045539, BC056891, CA389350, CA448628, DC404273

Consensus CDS

CCDS12712.2

Conserved Domains (2) summary

pfam00619
Location:403 → 485

CARD; Caspase recruitment domain

pfam13553
Location:132 → 386

FIIND; Function to find
NM_001351784.2 → NP_001338713.1 caspase recruitment domain-containing protein 8 isoform e

Status: REVIEWED

Source sequence(s)

AC011466, AF322184, AF511652, BC056891, CA448628, CR983845, DC347384, DC382648, DC404273

Conserved Domains (2) summary

pfam00619
Location:348 → 430

CARD; Caspase recruitment domain

pfam13553
Location:77 → 331

FIIND; Function to find
NM_001351786.2 → NP_001338715.1 caspase recruitment domain-containing protein 8 isoform f

Status: REVIEWED

Source sequence(s)

AC011466, AF322184, AF511652, BC056891, CA448628, CR983845, DC382648, DC404273

Conserved Domains (2) summary

pfam00619
Location:341 → 423

CARD; Caspase recruitment domain

pfam13553
Location:70 → 324

FIIND; Function to find
NM_001351787.2 → NP_001338716.1 caspase recruitment domain-containing protein 8 isoform g

Status: REVIEWED

Source sequence(s)

AC011466, AF143869, AK302327, DC382648, DC404273

Conserved Domains (1) summary

pfam13553
Location:77 → 331

FIIND; Function to find
NM_001351788.2 → NP_001338717.1 caspase recruitment domain-containing protein 8 isoform h

Status: REVIEWED

Source sequence(s)

AC011466, AF322184, AF511652, BC056891, CA448628, DC382648, DC404273

Conserved Domains (1) summary

pfam13553
Location:132 → 337

FIIND; Function to find
NM_001351789.2 → NP_001338718.1 caspase recruitment domain-containing protein 8 isoform h

Status: REVIEWED

Source sequence(s)

AC011466, AF322184, AF511652, BC056891, CA448628, DC382648, DC404273

Conserved Domains (1) summary

pfam13553
Location:132 → 337

FIIND; Function to find
NM_001351790.2 → NP_001338719.1 caspase recruitment domain-containing protein 8 isoform i

Status: REVIEWED

Source sequence(s)

AC011466, AF322184, AF511652, BC056891, CA448628, CB119078, DC404273

Conserved Domains (1) summary

pfam13553
Location:101 → 306

FIIND; Function to find
NM_001351791.2 → NP_001338720.1 caspase recruitment domain-containing protein 8 isoform j

Status: REVIEWED

Source sequence(s)

AC011466, AF322184, AF511652, BC056891, CA448628, DA675182, DC382648, DC404273

Conserved Domains (1) summary

pfam13553
Location:77 → 282

FIIND; Function to find
NM_001351792.2 → NP_001338721.1 caspase recruitment domain-containing protein 8 isoform j

Status: REVIEWED

Source sequence(s)

AC011466, AF322184, AF511652, BC056891, CA448628, DA675182, DC347384, DC404273

Conserved Domains (1) summary

pfam13553
Location:77 → 282

FIIND; Function to find
NM_001365950.1 → NP_001352879.1 caspase recruitment domain-containing protein 8 isoform k

Status: REVIEWED

Source sequence(s)

AC008392, AC011466

UniProtKB/TrEMBL

A0A024QZD3

Conserved Domains (2) summary

pfam00619
Location:347 → 429

CARD; Caspase recruitment domain

pfam13553
Location:77 → 330

FIIND; Function to find
NM_014959.5 → NP_055774.2 caspase recruitment domain-containing protein 8 isoform b

See identical proteins and their annotated locations for NP_055774.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a. Variants 2, 3 and 11 encode the same isoform (b).

Source sequence(s)

AC011466, AF322184, AF511652, BC045539, BC056891, CA389350, CA448628, DC404273

Consensus CDS

CCDS12712.2

UniProtKB/Swiss-Prot

Q9Y2G2

Related

ENSP00000428736.1, ENST00000520153.5

Conserved Domains (2) summary

pfam00619
Location:403 → 485

CARD; Caspase recruitment domain

pfam13553
Location:132 → 386

FIIND; Function to find

RNA

NR_033678.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (7) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC011466, AF322184, CA448628

Related

ENST00000518622.5
NR_033679.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (8) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC011466, BC056891, CA448628, EU118121
NR_033680.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (9) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC011466, AF511652, CA448628
NR_147707.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC011466, AF143869, AK302327, DC347384, DC404273

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

48179825..48255946 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017026485.2 → XP_016881974.1 caspase recruitment domain-containing protein 8 isoform X6
XM_047438455.1 → XP_047294411.1 caspase recruitment domain-containing protein 8 isoform X6
XM_047438461.1 → XP_047294417.1 caspase recruitment domain-containing protein 8 isoform X12
XM_047438453.1 → XP_047294409.1 caspase recruitment domain-containing protein 8 isoform X5
XM_047438454.1 → XP_047294410.1 caspase recruitment domain-containing protein 8 isoform X5
XM_011526650.3 → XP_011524952.1 caspase recruitment domain-containing protein 8 isoform X14

See identical proteins and their annotated locations for XP_011524952.1

UniProtKB/Swiss-Prot

Q9Y2G2

Conserved Domains (1) summary

pfam13553
Location:182 → 387

FIIND; Function to find
XM_047438463.1 → XP_047294419.1 caspase recruitment domain-containing protein 8 isoform X16
XM_047438447.1 → XP_047294403.1 caspase recruitment domain-containing protein 8 isoform X3
XM_047438437.1 → XP_047294393.1 caspase recruitment domain-containing protein 8 isoform X1

UniProtKB/Swiss-Prot

Q96P82

Related

ENSP00000375767.3, ENST00000391898.7
XM_047438452.1 → XP_047294408.1 caspase recruitment domain-containing protein 8 isoform X4
XM_006723097.5 → XP_006723160.1 caspase recruitment domain-containing protein 8 isoform X3

See identical proteins and their annotated locations for XP_006723160.1

UniProtKB/Swiss-Prot

Q9Y2G2

Related

ENSP00000427858.1, ENST00000521613.5

Conserved Domains (2) summary

pfam00619
Location:403 → 485

CARD; Caspase recruitment domain

pfam13553
Location:132 → 386

FIIND; Function to find
XM_017026482.3 → XP_016881971.1 caspase recruitment domain-containing protein 8 isoform X2

Conserved Domains (2) summary

pfam00619
Location:452 → 534

CARD; Caspase recruitment domain

pfam13553
Location:182 → 435

FIIND; Function to find
XM_006723093.5 → XP_006723156.1 caspase recruitment domain-containing protein 8 isoform X1

See identical proteins and their annotated locations for XP_006723156.1

UniProtKB/Swiss-Prot

Q96P82, Q9Y2G2

Conserved Domains (2) summary

pfam00619
Location:453 → 535

CARD; Caspase recruitment domain

pfam13553
Location:182 → 436

FIIND; Function to find
XM_017026483.3 → XP_016881972.1 caspase recruitment domain-containing protein 8 isoform X3

UniProtKB/Swiss-Prot

Q9Y2G2

Conserved Domains (2) summary

pfam00619
Location:403 → 485

CARD; Caspase recruitment domain

pfam13553
Location:132 → 386

FIIND; Function to find
XM_011526643.4 → XP_011524945.1 caspase recruitment domain-containing protein 8 isoform X1

See identical proteins and their annotated locations for XP_011524945.1

UniProtKB/Swiss-Prot

Q96P82, Q9Y2G2

Conserved Domains (2) summary

pfam00619
Location:453 → 535

CARD; Caspase recruitment domain

pfam13553
Location:182 → 436

FIIND; Function to find
XM_047438446.1 → XP_047294402.1 caspase recruitment domain-containing protein 8 isoform X3
XM_017026484.3 → XP_016881973.1 caspase recruitment domain-containing protein 8 isoform X4
XM_047438439.1 → XP_047294395.1 caspase recruitment domain-containing protein 8 isoform X2
XM_047438449.1 → XP_047294405.1 caspase recruitment domain-containing protein 8 isoform X4
XM_006723096.5 → XP_006723159.1 caspase recruitment domain-containing protein 8 isoform X3

See identical proteins and their annotated locations for XP_006723159.1

UniProtKB/Swiss-Prot

Q9Y2G2

Conserved Domains (2) summary

pfam00619
Location:403 → 485

CARD; Caspase recruitment domain

pfam13553
Location:132 → 386

FIIND; Function to find
XM_006723092.5 → XP_006723155.1 caspase recruitment domain-containing protein 8 isoform X1

See identical proteins and their annotated locations for XP_006723155.1

UniProtKB/Swiss-Prot

Q96P82, Q9Y2G2

Conserved Domains (2) summary

pfam00619
Location:453 → 535

CARD; Caspase recruitment domain

pfam13553
Location:182 → 436

FIIND; Function to find
XM_047438435.1 → XP_047294391.1 caspase recruitment domain-containing protein 8 isoform X1

UniProtKB/Swiss-Prot

Q96P82
XM_047438445.1 → XP_047294401.1 caspase recruitment domain-containing protein 8 isoform X3
XM_047438441.1 → XP_047294397.1 caspase recruitment domain-containing protein 8 isoform X2
XM_047438436.1 → XP_047294392.1 caspase recruitment domain-containing protein 8 isoform X1

UniProtKB/Swiss-Prot

Q96P82
XM_047438451.1 → XP_047294407.1 caspase recruitment domain-containing protein 8 isoform X4
XM_047438444.1 → XP_047294400.1 caspase recruitment domain-containing protein 8 isoform X3
XM_047438443.1 → XP_047294399.1 caspase recruitment domain-containing protein 8 isoform X2
XM_047438459.1 → XP_047294415.1 caspase recruitment domain-containing protein 8 isoform X10
XM_047438450.1 → XP_047294406.1 caspase recruitment domain-containing protein 8 isoform X4
XM_011526641.4 → XP_011524943.1 caspase recruitment domain-containing protein 8 isoform X1

See identical proteins and their annotated locations for XP_011524943.1

UniProtKB/Swiss-Prot

Q96P82, Q9Y2G2

Conserved Domains (2) summary

pfam00619
Location:453 → 535

CARD; Caspase recruitment domain

pfam13553
Location:182 → 436

FIIND; Function to find
XM_047438438.1 → XP_047294394.1 caspase recruitment domain-containing protein 8 isoform X1

UniProtKB/Swiss-Prot

Q96P82
XM_047438448.1 → XP_047294404.1 caspase recruitment domain-containing protein 8 isoform X4
XM_047438440.1 → XP_047294396.1 caspase recruitment domain-containing protein 8 isoform X2
XM_047438434.1 → XP_047294390.1 caspase recruitment domain-containing protein 8 isoform X1

UniProtKB/Swiss-Prot

Q96P82
XM_047438442.1 → XP_047294398.1 caspase recruitment domain-containing protein 8 isoform X2
XM_047438458.1 → XP_047294414.1 caspase recruitment domain-containing protein 8 isoform X9
XM_047438457.1 → XP_047294413.1 caspase recruitment domain-containing protein 8 isoform X8
XM_047438456.1 → XP_047294412.1 caspase recruitment domain-containing protein 8 isoform X7
XM_017026487.3 → XP_016881976.1 caspase recruitment domain-containing protein 8 isoform X13

Conserved Domains (2) summary

pfam00619
Location:341 → 423

CARD; Caspase recruitment domain

pfam13553
Location:70 → 324

FIIND; Function to find
XM_047438460.1 → XP_047294416.1 caspase recruitment domain-containing protein 8 isoform X11
XM_047438465.1 → XP_047294421.1 caspase recruitment domain-containing protein 8 isoform X18
XM_047438462.1 → XP_047294418.1 caspase recruitment domain-containing protein 8 isoform X15
XM_006723110.4 → XP_006723173.2 caspase recruitment domain-containing protein 8 isoform X17
XM_047438464.1 → XP_047294420.1 caspase recruitment domain-containing protein 8 isoform X17