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CARD8 caspase recruitment domain family member 8 [ Homo sapiens (human) ]

Gene ID: 22900, updated on 7-Apr-2024

Summary

Official Symbol
CARD8provided by HGNC
Official Full Name
caspase recruitment domain family member 8provided by HGNC
Primary source
HGNC:HGNC:17057
See related
Ensembl:ENSG00000105483 MIM:609051; AllianceGenome:HGNC:17057
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NDPP; DACAR; DAKAR; NDPP1; TUCAN; CARDINAL
Summary
The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
Expression
Broad expression in spleen (RPKM 13.6), lymph node (RPKM 11.5) and 24 other tissues See more
Orthologs
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Genomic context

See CARD8 in Genome Data Viewer
Location:
19q13.33
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (48179825..48255946, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (51197212..51250053, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48706405..48759203, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48564610-48565203 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48565204-48565796 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:48565797-48566389 Neighboring gene PLA2G4C antisense RNA 1 Neighboring gene phospholipase A2 group IVC Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14871 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10871 Neighboring gene DNA ligase 1 Neighboring gene uncharacterized LOC107985293 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:48673083-48673742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10874 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14872 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:48691653-48691885 Neighboring gene zinc finger SWIM-type containing 9 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48699771-48700283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14873 Neighboring gene uncharacterized LOC124904734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14874 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:48763364-48763544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14875 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14876 Neighboring gene CARD8 antisense RNA 1 Neighboring gene ZNF114 antisense RNA 1 Neighboring gene vomeronasal 1 receptor 97 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48774579-48775085 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48775086-48775591 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14878 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48794631-48795279 Neighboring gene zinc finger protein 114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48798559-48799060 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48799061-48799560 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48800397-48800914 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48806581-48807105 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48807106-48807629 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48811608-48812298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48812299-48812988 Neighboring gene Sharpr-MPRA regulatory region 8297 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10875 Neighboring gene uncharacterized LOC124904735 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14879 Neighboring gene Sharpr-MPRA regulatory region 73 Neighboring gene outer dynein arm docking complex subunit 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ18119, FLJ18121, KIAA0955, MGC57162, DKFZp779L0366

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in CARD8 inflammasome complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in antiviral innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in inhibition of cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of NLRP3 inflammasome complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of interleukin-1 beta production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of lipopolysaccharide-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-1 beta production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in self proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of NLRP3 inflammasome complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of NLRP3 inflammasome complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
caspase recruitment domain-containing protein 8
Names
CARD inhibitor of NF-kappaB-activating ligands
apoptotic protein NDPP1
tumor up-regulated CARD-containing antagonist of CASP9
tumor up-regulated CARD-containing antagonist of caspase nine

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029574.3 RefSeqGene

    Range
    5034..52860
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184900.3NP_001171829.1  caspase recruitment domain-containing protein 8 isoform a

    See identical proteins and their annotated locations for NP_001171829.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a, also referred to as T60). Variants 1 and 10 encode the same protein (isoform a).
    Source sequence(s)
    AC011466, BC056891, CA448628, CB119078, DC404273, EU118120
    Consensus CDS
    CCDS54289.1
    UniProtKB/Swiss-Prot
    B5KVR6, B5KVR8, B7Z496, B7Z4A2, E5RFV9, E9PEM7, G3XAM9, Q6PGP8, Q96P82, Q9Y2G2
    UniProtKB/TrEMBL
    I6L9C6
    Related
    ENSP00000499211.1, ENST00000651546.1
    Conserved Domains (2) summary
    pfam00619
    Location:453535
    CARD; Caspase recruitment domain
    pfam13553
    Location:182436
    FIIND; Function to find
  2. NM_001184901.1NP_001171830.1  caspase recruitment domain-containing protein 8 isoform b

    See identical proteins and their annotated locations for NP_001171830.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a. Variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AC011466, AK297045, AK297069, BC046136, CA448628
    Consensus CDS
    CCDS12712.2
    UniProtKB/TrEMBL
    I6L9C6
    Related
    ENSP00000391248.2, ENST00000447740.6
    Conserved Domains (2) summary
    pfam00619
    Location:403485
    CARD; Caspase recruitment domain
    pfam13553
    Location:132386
    FIIND; Function to find
  3. NM_001184902.2NP_001171831.1  caspase recruitment domain-containing protein 8 isoform c

    See identical proteins and their annotated locations for NP_001171831.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate exon in the 3' coding region, which results in a frameshift compared to variant 1. This results in a shorter protein (isoform c), compared to isoform a. Variants 4 and 5 encode the same isoform (c).
    Source sequence(s)
    AC011466, AF322184, AF511652, BC056891, CA448628, CB119078, DC404273
    Consensus CDS
    CCDS54288.1
    UniProtKB/Swiss-Prot
    Q9Y2G2
    Related
    ENSP00000429839.1, ENST00000520753.5
    Conserved Domains (1) summary
    pfam13553
    Location:182387
    FIIND; Function to find
  4. NM_001184903.1NP_001171832.1  caspase recruitment domain-containing protein 8 isoform c

    See identical proteins and their annotated locations for NP_001171832.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate exon in the 3' coding region, which results in a frameshift compared to variant 1. This results in a shorter protein (isoform c), compared to isoform a. Variants 4 and 5 encode the same isoform (c).
    Source sequence(s)
    AC011466, AF322184, AK297045, BC046136, CA448628
    Consensus CDS
    CCDS54288.1
    UniProtKB/Swiss-Prot
    Q9Y2G2
    Related
    ENSP00000430747.1, ENST00000520015.5
    Conserved Domains (1) summary
    pfam13553
    Location:182387
    FIIND; Function to find
  5. NM_001184904.2NP_001171833.1  caspase recruitment domain-containing protein 8 isoform d

    See identical proteins and their annotated locations for NP_001171833.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, 3' coding region, and 3' UTR compared to variant 1. The resulting isoform (d) is shorter than isoform a.
    Source sequence(s)
    AC011466, AI040349, BC046136, DC404273
    Consensus CDS
    CCDS54287.1
    UniProtKB/TrEMBL
    E5RFV9
    Related
    ENSP00000430108.1, ENST00000519332.5
  6. NM_001351782.2NP_001338711.1  caspase recruitment domain-containing protein 8 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1 and 10 encode the same protein (isoform a).
    Source sequence(s)
    AC011466, BC056891, CA448628, CB119078, DC404273, EU118120
    Consensus CDS
    CCDS54289.1
    UniProtKB/Swiss-Prot
    B5KVR6, B5KVR8, B7Z496, B7Z4A2, E5RFV9, E9PEM7, G3XAM9, Q6PGP8, Q96P82, Q9Y2G2
    UniProtKB/TrEMBL
    I6L9C6
    Related
    ENSP00000428883.1, ENST00000519940.6
    Conserved Domains (2) summary
    pfam00619
    Location:453535
    CARD; Caspase recruitment domain
    pfam13553
    Location:182436
    FIIND; Function to find
  7. NM_001351783.2NP_001338712.1  caspase recruitment domain-containing protein 8 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC008392, AC011466, AF322184, AF511652, BC045539, BC056891, CA389350, CA448628, DC404273
    Consensus CDS
    CCDS12712.2
    UniProtKB/TrEMBL
    I6L9C6
    Conserved Domains (2) summary
    pfam00619
    Location:403485
    CARD; Caspase recruitment domain
    pfam13553
    Location:132386
    FIIND; Function to find
  8. NM_001351784.2NP_001338713.1  caspase recruitment domain-containing protein 8 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF322184, AF511652, BC056891, CA448628, CR983845, DC347384, DC382648, DC404273
    UniProtKB/TrEMBL
    B5KVR7
    Conserved Domains (2) summary
    pfam00619
    Location:348430
    CARD; Caspase recruitment domain
    pfam13553
    Location:77331
    FIIND; Function to find
  9. NM_001351786.2NP_001338715.1  caspase recruitment domain-containing protein 8 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF322184, AF511652, BC056891, CA448628, CR983845, DC382648, DC404273
    UniProtKB/TrEMBL
    B5KVR7
    Conserved Domains (2) summary
    pfam00619
    Location:341423
    CARD; Caspase recruitment domain
    pfam13553
    Location:70324
    FIIND; Function to find
  10. NM_001351787.2NP_001338716.1  caspase recruitment domain-containing protein 8 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF143869, AK302327, DC382648, DC404273
    Conserved Domains (1) summary
    pfam13553
    Location:77331
    FIIND; Function to find
  11. NM_001351788.2NP_001338717.1  caspase recruitment domain-containing protein 8 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF322184, AF511652, BC056891, CA448628, DC382648, DC404273
    Conserved Domains (1) summary
    pfam13553
    Location:132337
    FIIND; Function to find
  12. NM_001351789.2NP_001338718.1  caspase recruitment domain-containing protein 8 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF322184, AF511652, BC056891, CA448628, DC382648, DC404273
    Conserved Domains (1) summary
    pfam13553
    Location:132337
    FIIND; Function to find
  13. NM_001351790.2NP_001338719.1  caspase recruitment domain-containing protein 8 isoform i

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF322184, AF511652, BC056891, CA448628, CB119078, DC404273
    Conserved Domains (1) summary
    pfam13553
    Location:101306
    FIIND; Function to find
  14. NM_001351791.2NP_001338720.1  caspase recruitment domain-containing protein 8 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF322184, AF511652, BC056891, CA448628, DA675182, DC382648, DC404273
    Conserved Domains (1) summary
    pfam13553
    Location:77282
    FIIND; Function to find
  15. NM_001351792.2NP_001338721.1  caspase recruitment domain-containing protein 8 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF322184, AF511652, BC056891, CA448628, DA675182, DC347384, DC404273
    Conserved Domains (1) summary
    pfam13553
    Location:77282
    FIIND; Function to find
  16. NM_001365950.1NP_001352879.1  caspase recruitment domain-containing protein 8 isoform k

    Status: REVIEWED

    Source sequence(s)
    AC008392, AC011466
    UniProtKB/TrEMBL
    B5KVR7
    Conserved Domains (2) summary
    pfam00619
    Location:347429
    CARD; Caspase recruitment domain
    pfam13553
    Location:77330
    FIIND; Function to find
  17. NM_001426741.1NP_001413670.1  caspase recruitment domain-containing protein 8 isoform l

    Status: REVIEWED

    Source sequence(s)
    CP068259
  18. NM_014959.5NP_055774.2  caspase recruitment domain-containing protein 8 isoform b

    See identical proteins and their annotated locations for NP_055774.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a. Variants 2, 3 and 11 encode the same isoform (b).
    Source sequence(s)
    AC011466, AF322184, AF511652, BC045539, BC056891, CA389350, CA448628, DC404273
    Consensus CDS
    CCDS12712.2
    UniProtKB/TrEMBL
    I6L9C6
    Related
    ENSP00000428736.1, ENST00000520153.5
    Conserved Domains (2) summary
    pfam00619
    Location:403485
    CARD; Caspase recruitment domain
    pfam13553
    Location:132386
    FIIND; Function to find

RNA

  1. NR_033678.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC011466, AF322184, CA448628
    Related
    ENST00000518622.5
  2. NR_033679.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC011466, BC056891, CA448628, EU118121
  3. NR_033680.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC011466, AF511652, CA448628
  4. NR_147707.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF143869, AK302327, DC347384, DC404273

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    48179825..48255946 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026485.2XP_016881974.1  caspase recruitment domain-containing protein 8 isoform X6

    UniProtKB/TrEMBL
    I6L9C6
  2. XM_047438455.1XP_047294411.1  caspase recruitment domain-containing protein 8 isoform X6

  3. XM_047438461.1XP_047294417.1  caspase recruitment domain-containing protein 8 isoform X12

  4. XM_047438453.1XP_047294409.1  caspase recruitment domain-containing protein 8 isoform X5

  5. XM_047438454.1XP_047294410.1  caspase recruitment domain-containing protein 8 isoform X5

  6. XM_011526650.3XP_011524952.1  caspase recruitment domain-containing protein 8 isoform X14

    See identical proteins and their annotated locations for XP_011524952.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (1) summary
    pfam13553
    Location:182387
    FIIND; Function to find
  7. XM_047438463.1XP_047294419.1  caspase recruitment domain-containing protein 8 isoform X16

  8. XM_047438447.1XP_047294403.1  caspase recruitment domain-containing protein 8 isoform X3

  9. XM_047438437.1XP_047294393.1  caspase recruitment domain-containing protein 8 isoform X1

    UniProtKB/Swiss-Prot
    B5KVR6, B5KVR8, B7Z496, B7Z4A2, E5RFV9, E9PEM7, G3XAM9, Q6PGP8, Q96P82, Q9Y2G2
    Related
    ENSP00000375767.3, ENST00000391898.7
  10. XM_047438452.1XP_047294408.1  caspase recruitment domain-containing protein 8 isoform X4

  11. XM_006723097.5XP_006723160.1  caspase recruitment domain-containing protein 8 isoform X3

    See identical proteins and their annotated locations for XP_006723160.1

    UniProtKB/TrEMBL
    I6L9C6
    Related
    ENSP00000427858.1, ENST00000521613.5
    Conserved Domains (2) summary
    pfam00619
    Location:403485
    CARD; Caspase recruitment domain
    pfam13553
    Location:132386
    FIIND; Function to find
  12. XM_017026482.3XP_016881971.1  caspase recruitment domain-containing protein 8 isoform X2

    UniProtKB/TrEMBL
    I6L9C6
    Conserved Domains (2) summary
    pfam00619
    Location:452534
    CARD; Caspase recruitment domain
    pfam13553
    Location:182435
    FIIND; Function to find
  13. XM_006723093.5XP_006723156.1  caspase recruitment domain-containing protein 8 isoform X1

    See identical proteins and their annotated locations for XP_006723156.1

    UniProtKB/Swiss-Prot
    B5KVR6, B5KVR8, B7Z496, B7Z4A2, E5RFV9, E9PEM7, G3XAM9, Q6PGP8, Q96P82, Q9Y2G2
    UniProtKB/TrEMBL
    I6L9C6
    Conserved Domains (2) summary
    pfam00619
    Location:453535
    CARD; Caspase recruitment domain
    pfam13553
    Location:182436
    FIIND; Function to find
  14. XM_017026483.3XP_016881972.1  caspase recruitment domain-containing protein 8 isoform X3

    UniProtKB/TrEMBL
    I6L9C6
    Conserved Domains (2) summary
    pfam00619
    Location:403485
    CARD; Caspase recruitment domain
    pfam13553
    Location:132386
    FIIND; Function to find
  15. XM_011526643.4XP_011524945.1  caspase recruitment domain-containing protein 8 isoform X1

    See identical proteins and their annotated locations for XP_011524945.1

    UniProtKB/Swiss-Prot
    B5KVR6, B5KVR8, B7Z496, B7Z4A2, E5RFV9, E9PEM7, G3XAM9, Q6PGP8, Q96P82, Q9Y2G2
    UniProtKB/TrEMBL
    I6L9C6
    Conserved Domains (2) summary
    pfam00619
    Location:453535
    CARD; Caspase recruitment domain
    pfam13553
    Location:182436
    FIIND; Function to find
  16. XM_047438446.1XP_047294402.1  caspase recruitment domain-containing protein 8 isoform X3

  17. XM_017026484.3XP_016881973.1  caspase recruitment domain-containing protein 8 isoform X4

    UniProtKB/TrEMBL
    I6L9C6
  18. XM_047438439.1XP_047294395.1  caspase recruitment domain-containing protein 8 isoform X2

  19. XM_047438449.1XP_047294405.1  caspase recruitment domain-containing protein 8 isoform X4

  20. XM_006723096.5XP_006723159.1  caspase recruitment domain-containing protein 8 isoform X3

    See identical proteins and their annotated locations for XP_006723159.1

    UniProtKB/TrEMBL
    I6L9C6
    Conserved Domains (2) summary
    pfam00619
    Location:403485
    CARD; Caspase recruitment domain
    pfam13553
    Location:132386
    FIIND; Function to find
  21. XM_006723092.5XP_006723155.1  caspase recruitment domain-containing protein 8 isoform X1

    See identical proteins and their annotated locations for XP_006723155.1

    UniProtKB/Swiss-Prot
    B5KVR6, B5KVR8, B7Z496, B7Z4A2, E5RFV9, E9PEM7, G3XAM9, Q6PGP8, Q96P82, Q9Y2G2
    UniProtKB/TrEMBL
    I6L9C6
    Conserved Domains (2) summary
    pfam00619
    Location:453535
    CARD; Caspase recruitment domain
    pfam13553
    Location:182436
    FIIND; Function to find
  22. XM_047438435.1XP_047294391.1  caspase recruitment domain-containing protein 8 isoform X1

    UniProtKB/Swiss-Prot
    B5KVR6, B5KVR8, B7Z496, B7Z4A2, E5RFV9, E9PEM7, G3XAM9, Q6PGP8, Q96P82, Q9Y2G2
  23. XM_047438445.1XP_047294401.1  caspase recruitment domain-containing protein 8 isoform X3

  24. XM_047438441.1XP_047294397.1  caspase recruitment domain-containing protein 8 isoform X2

  25. XM_047438436.1XP_047294392.1  caspase recruitment domain-containing protein 8 isoform X1

    UniProtKB/Swiss-Prot
    B5KVR6, B5KVR8, B7Z496, B7Z4A2, E5RFV9, E9PEM7, G3XAM9, Q6PGP8, Q96P82, Q9Y2G2
  26. XM_047438451.1XP_047294407.1  caspase recruitment domain-containing protein 8 isoform X4

  27. XM_047438444.1XP_047294400.1  caspase recruitment domain-containing protein 8 isoform X3

  28. XM_047438443.1XP_047294399.1  caspase recruitment domain-containing protein 8 isoform X2

  29. XM_047438459.1XP_047294415.1  caspase recruitment domain-containing protein 8 isoform X10

  30. XM_047438450.1XP_047294406.1  caspase recruitment domain-containing protein 8 isoform X4

  31. XM_011526641.4XP_011524943.1  caspase recruitment domain-containing protein 8 isoform X1

    See identical proteins and their annotated locations for XP_011524943.1

    UniProtKB/Swiss-Prot
    B5KVR6, B5KVR8, B7Z496, B7Z4A2, E5RFV9, E9PEM7, G3XAM9, Q6PGP8, Q96P82, Q9Y2G2
    UniProtKB/TrEMBL
    I6L9C6
    Conserved Domains (2) summary
    pfam00619
    Location:453535
    CARD; Caspase recruitment domain
    pfam13553
    Location:182436
    FIIND; Function to find
  32. XM_047438438.1XP_047294394.1  caspase recruitment domain-containing protein 8 isoform X1

    UniProtKB/Swiss-Prot
    B5KVR6, B5KVR8, B7Z496, B7Z4A2, E5RFV9, E9PEM7, G3XAM9, Q6PGP8, Q96P82, Q9Y2G2
  33. XM_047438448.1XP_047294404.1  caspase recruitment domain-containing protein 8 isoform X4

  34. XM_047438440.1XP_047294396.1  caspase recruitment domain-containing protein 8 isoform X2

  35. XM_047438434.1XP_047294390.1  caspase recruitment domain-containing protein 8 isoform X1

    UniProtKB/Swiss-Prot
    B5KVR6, B5KVR8, B7Z496, B7Z4A2, E5RFV9, E9PEM7, G3XAM9, Q6PGP8, Q96P82, Q9Y2G2
  36. XM_047438442.1XP_047294398.1  caspase recruitment domain-containing protein 8 isoform X2

  37. XM_047438458.1XP_047294414.1  caspase recruitment domain-containing protein 8 isoform X9

  38. XM_047438457.1XP_047294413.1  caspase recruitment domain-containing protein 8 isoform X8

  39. XM_047438456.1XP_047294412.1  caspase recruitment domain-containing protein 8 isoform X7

  40. XM_017026487.3XP_016881976.1  caspase recruitment domain-containing protein 8 isoform X13

    UniProtKB/TrEMBL
    B5KVR7
    Conserved Domains (2) summary
    pfam00619
    Location:341423
    CARD; Caspase recruitment domain
    pfam13553
    Location:70324
    FIIND; Function to find
  41. XM_047438460.1XP_047294416.1  caspase recruitment domain-containing protein 8 isoform X11

  42. XM_047438465.1XP_047294421.1  caspase recruitment domain-containing protein 8 isoform X18

  43. XM_047438462.1XP_047294418.1  caspase recruitment domain-containing protein 8 isoform X15

  44. XM_006723110.4XP_006723173.2  caspase recruitment domain-containing protein 8 isoform X17

  45. XM_047438464.1XP_047294420.1  caspase recruitment domain-containing protein 8 isoform X17

RNA

  1. XR_001753636.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    51197212..51250053 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320261.1XP_054176236.1  caspase recruitment domain-containing protein 8 isoform X6

  2. XM_054320262.1XP_054176237.1  caspase recruitment domain-containing protein 8 isoform X6

  3. XM_054320266.1XP_054176241.1  caspase recruitment domain-containing protein 8 isoform X12

  4. XM_054320259.1XP_054176234.1  caspase recruitment domain-containing protein 8 isoform X5

  5. XM_054320260.1XP_054176235.1  caspase recruitment domain-containing protein 8 isoform X5

  6. XM_054320268.1XP_054176243.1  caspase recruitment domain-containing protein 8 isoform X14

  7. XM_054320270.1XP_054176245.1  caspase recruitment domain-containing protein 8 isoform X16

  8. XM_054320251.1XP_054176226.1  caspase recruitment domain-containing protein 8 isoform X3

  9. XM_054320237.1XP_054176212.1  caspase recruitment domain-containing protein 8 isoform X1

  10. XM_054320258.1XP_054176233.1  caspase recruitment domain-containing protein 8 isoform X4

  11. XM_054320247.1XP_054176222.1  caspase recruitment domain-containing protein 8 isoform X3

  12. XM_054320243.1XP_054176218.1  caspase recruitment domain-containing protein 8 isoform X2

  13. XM_054320235.1XP_054176210.1  caspase recruitment domain-containing protein 8 isoform X1

  14. XM_054320250.1XP_054176225.1  caspase recruitment domain-containing protein 8 isoform X3

  15. XM_054320239.1XP_054176214.1  caspase recruitment domain-containing protein 8 isoform X1

  16. XM_054320249.1XP_054176224.1  caspase recruitment domain-containing protein 8 isoform X3

  17. XM_054320253.1XP_054176228.1  caspase recruitment domain-containing protein 8 isoform X4

  18. XM_054320240.1XP_054176215.1  caspase recruitment domain-containing protein 8 isoform X2

  19. XM_054320255.1XP_054176230.1  caspase recruitment domain-containing protein 8 isoform X4

  20. XM_054320252.1XP_054176227.1  caspase recruitment domain-containing protein 8 isoform X3

  21. XM_054320232.1XP_054176207.1  caspase recruitment domain-containing protein 8 isoform X1

  22. XM_054320234.1XP_054176209.1  caspase recruitment domain-containing protein 8 isoform X1

  23. XM_054320248.1XP_054176223.1  caspase recruitment domain-containing protein 8 isoform X3

  24. XM_054320242.1XP_054176217.1  caspase recruitment domain-containing protein 8 isoform X2

  25. XM_054320236.1XP_054176211.1  caspase recruitment domain-containing protein 8 isoform X1

  26. XM_054320257.1XP_054176232.1  caspase recruitment domain-containing protein 8 isoform X4

  27. XM_054320246.1XP_054176221.1  caspase recruitment domain-containing protein 8 isoform X3

  28. XM_054320245.1XP_054176220.1  caspase recruitment domain-containing protein 8 isoform X2

  29. XM_054320256.1XP_054176231.1  caspase recruitment domain-containing protein 8 isoform X4

  30. XM_054320233.1XP_054176208.1  caspase recruitment domain-containing protein 8 isoform X1

  31. XM_054320238.1XP_054176213.1  caspase recruitment domain-containing protein 8 isoform X1

  32. XM_054320254.1XP_054176229.1  caspase recruitment domain-containing protein 8 isoform X4

  33. XM_054320241.1XP_054176216.1  caspase recruitment domain-containing protein 8 isoform X2

  34. XM_054320231.1XP_054176206.1  caspase recruitment domain-containing protein 8 isoform X1

  35. XM_054320244.1XP_054176219.1  caspase recruitment domain-containing protein 8 isoform X2

  36. XM_054320265.1XP_054176240.1  caspase recruitment domain-containing protein 8 isoform X19

  37. XM_054320267.1XP_054176242.1  caspase recruitment domain-containing protein 8 isoform X13

  38. XM_054320264.1XP_054176239.1  caspase recruitment domain-containing protein 8 isoform X11

  39. XM_054320263.1XP_054176238.1  caspase recruitment domain-containing protein 8 isoform X11

  40. XM_054320271.1XP_054176246.1  caspase recruitment domain-containing protein 8 isoform X18

  41. XM_054320269.1XP_054176244.1  caspase recruitment domain-containing protein 8 isoform X15

RNA

  1. XR_008485122.1 RNA Sequence

  2. XR_008485124.1 RNA Sequence

  3. XR_008485123.1 RNA Sequence

  4. XR_008485125.1 RNA Sequence