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CARD8 caspase recruitment domain family member 8 [ Homo sapiens (human) ]

Gene ID: 22900, updated on 17-Jun-2019

Summary

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Official Symbol
CARD8provided by HGNC
Official Full Name
caspase recruitment domain family member 8provided by HGNC
Primary source
HGNC:HGNC:17057
See related
Ensembl:ENSG00000105483 MIM:609051
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NDPP; DACAR; DAKAR; NDPP1; TUCAN; CARDINAL
Summary
The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
Expression
Broad expression in spleen (RPKM 13.6), lymph node (RPKM 11.5) and 24 other tissues See more
Orthologs
all

Genomic context

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See CARD8 in Genome Data Viewer
Location:
19q13.33
Exon count:
21
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (48203148..48256264, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48711343..48759203, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene DNA ligase 1 Neighboring gene uncharacterized LOC107985293 Neighboring gene zinc finger SWIM-type containing 9 Neighboring gene CARD8 antisense RNA 1 Neighboring gene vomeronasal 1 receptor 97 pseudogene Neighboring gene ZNF114 antisense RNA 1 Neighboring gene zinc finger protein 114 Neighboring gene coiled-coil domain containing 114 Neighboring gene Sharpr-MPRA regulatory region 73

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Association between caspase recruitment domain-containing protein 8 rs2043211 polymorphism and cardiovascular disease susceptibility: A systematic review and meta-analysis. Huang H, et al. Anatol J Cardiol, 2018 Aug. PMID 30088494, Free PMC Article
  2. Periodic Fever with Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis Syndrome Is Associated with a CARD8 Variant Unable To Bind the NLRP3 Inflammasome. Cheung MS, et al. J Immunol, 2017 Mar 1. PMID 28137891
  3. The Association between Polymorphism of CARD8 rs2043211 and Susceptibility to Arteriosclerosis Obliterans in Chinese Han Male Population. Zhang K, et al. Cell Physiol Biochem, 2017. PMID 28135700
  4. Is the CARD8 rs2043211 polymorphism associated with susceptibility to Crohn's disease? A meta-analysis. Zhang ZT, et al. Autoimmunity, 2015. PMID 26462578
  5. CARD8 gene variant is a risk factor for recurrent surgery in patients with Crohn's disease. Germain A, et al. Dig Liver Dis, 2015 Nov. PMID 26283210

See all (75) citations in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  1. The study showed that CARD8 rs2043211 polymorphism is associated with cardiovascular diseases (systematic review and meta-analysis).
    Title: Association between caspase recruitment domain-containing protein 8 rs2043211 polymorphism and cardiovascular disease susceptibility: A systematic review and meta-analysis.
  2. this study showed that the CARD8-C10X (rs2043211) AT genotype contributed to the susceptibility of multiple myeloma
    Title: The Genetic Polymorphisms of NLRP3 Inflammasome Associated with T Helper Cells in Patients with Multiple Myeloma.
  3. Our results showed that rs10754558 NLRP3 and rs2043211 CARD8 polymorphisms are associated with rheumatoid arthritis development (p value = 0.044, OR = 1.77, statistical power = 0.999) and severity measured by Health Assessment Questionnaire (HAQ) (p value = 0.03), respectively.
    Title: Polymorphisms and expression of inflammasome genes are associated with the development and severity of rheumatoid arthritis in Brazilian patients.
  4. this study found that the AT genotype of CARD8 (rs2043211) was significantly higher compared to TT genotype in high and intermediate risk chronic myeloid leukemia patients
    Title: The genetic polymorphism and expression profiles of NLRP3 inflammasome in patients with chronic myeloid leukemia.
  5. Review/Meta-analysis: CARD8 p.C10X SNP were not associated with the susceptibility to rheumatoid arthritis.
    Title: NLRP3 p.Q705K and CARD8 p.C10X single nucleotide polymorphisms are not associated with susceptibility to rheumatoid arthritis: a meta-analysis.
  6. these results identify a new CARD8 variant associated with periodic fever with aphthous stomatitis, pharyngitis, and cervical adenitis, and further suggest that disruption of the interaction between CARD8 and NLRP3 can regulate autoinflammation in patients
    Title: Periodic Fever with Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis Syndrome Is Associated with a CARD8 Variant Unable To Bind the NLRP3 Inflammasome.
  7. The over expression of CARD8 due to higher promoter activity of the TT genotype may result in a dramatically inflammatory immune response and then increase the susceptibility to Arteriosclerosis Obliterans.
    Title: The Association between Polymorphism of CARD8 rs2043211 and Susceptibility to Arteriosclerosis Obliterans in Chinese Han Male Population.
  8. High CARD8 expression is associated with malignant melanoma.
    Title: Genotyping and differential expression analysis of inflammasome genes in sporadic malignant melanoma reveal novel contribution of CARD8, IL1B and IL18 in melanoma susceptibility and progression.
  9. The CARD8 rs2043211 genetic variants was not implicated in the development of gout in the male Korean population. However, we found that in a pair-wise comparison of the CA/TT P2X7R and CARD8 genotype combination was shown to have an increased trend for the risk of gout.
    Title: Genetic Association for P2X7R rs3751142 and CARD8 rs2043211 Polymorphisms for Susceptibility of Gout in Korean Men: Multi-Center Study.
  10. The NLRP3 rs10754558 gene polymorphism was significantly associated with the occurrence of CAD, while the CARD8 rs2043211 gene polymorphism was not involved.
    Title: The NLRP3 rs10754558 Polymorphism Is Associated with the Occurrence and Prognosis of Coronary Artery Disease in the Chinese Han Population.
Submit: New GeneRIF Correction See all GeneRIFs (58)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from BioSystems

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  • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
  • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
    NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
  • Nucleotide-binding Oligomerization Domain (NOD) pathway, organism-specific biosystem (from WikiPathways)
    Nucleotide-binding Oligomerization Domain (NOD) pathway, organism-specific biosystemThe NOD (nucleotide-binding oligomerization domain) proteins NOD1 and NOD2 have important roles in innate immunity as sensors of microbial components derived from bacterial peptidoglycan. The importa...

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ18119, FLJ18121, KIAA0955, MGC57162, DKFZp779L0366

Gene Ontology Provided by GOA

Function Evidence Code Pubs
CARD domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
NACHT domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
cysteine-type endopeptidase activator activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
cysteine-type endopeptidase activator activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
activation of cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
  
inhibition of cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
 PubMed 
negative regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
negative regulation of interleukin-1 beta secretion IDA
Inferred from Direct Assay
more info
 PubMed 
negative regulation of lipopolysaccharide-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
negative regulation of tumor necrosis factor-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
positive regulation of interleukin-1 beta secretion IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
positive regulation of interleukin-1 beta secretion IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
NLRP3 inflammasome complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
NLRP3 inflammasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
cytosol IDA
Inferred from Direct Assay
more info
  
cytosol TAS
Traceable Author Statement
more info
  
inflammasome complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
  
nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
caspase recruitment domain-containing protein 8
Names
CARD inhibitor of NF-kappaB-activating ligands
apoptotic protein NDPP1
tumor up-regulated CARD-containing antagonist of CASP9
tumor up-regulated CARD-containing antagonist of caspase nine

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029574.2 RefSeqGene

    Range
    5324..53184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184900.3 → NP_001171829.1  caspase recruitment domain-containing protein 8 isoform a

    See identical proteins and their annotated locations for NP_001171829.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a, also referred to as T60). Variants 1 and 10 encode the same protein (isoform a).
    Source sequence(s)
    AC011466, BC056891, CA448628, CB119078, DC404273, EU118120
    Consensus CDS
    CCDS54289.1
    UniProtKB/Swiss-Prot
    Q9Y2G2
    Related
    ENSP00000499211.1, ENST00000651546.1
    Conserved Domains (2) summary
    pfam00619
    Location:453 → 535
    CARD; Caspase recruitment domain
    pfam13553
    Location:182 → 436
    FIIND; Function to find

  2. NM_001184901.1 → NP_001171830.1  caspase recruitment domain-containing protein 8 isoform b

    See identical proteins and their annotated locations for NP_001171830.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a. Variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AC011466, AK297045, AK297069, BC046136, CA448628
    Consensus CDS
    CCDS12712.2
    UniProtKB/Swiss-Prot
    Q9Y2G2
    Related
    ENSP00000391248.2, ENST00000447740.6
    Conserved Domains (2) summary
    pfam00619
    Location:403 → 485
    CARD; Caspase recruitment domain
    pfam13553
    Location:132 → 386
    FIIND; Function to find

  3. NM_001184902.2 → NP_001171831.1  caspase recruitment domain-containing protein 8 isoform c

    See identical proteins and their annotated locations for NP_001171831.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate exon in the 3' coding region, which results in a frameshift compared to variant 1. This results in a shorter protein (isoform c), compared to isoform a. Variants 4 and 5 encode the same isoform (c).
    Source sequence(s)
    AC011466, AF322184, AF511652, BC056891, CA448628, CB119078, DC404273
    Consensus CDS
    CCDS54288.1
    UniProtKB/Swiss-Prot
    Q9Y2G2
    Related
    ENSP00000429839.1, ENST00000520753.5
    Conserved Domains (1) summary
    pfam13553
    Location:182 → 387
    FIIND; Function to find

  4. NM_001184903.1 → NP_001171832.1  caspase recruitment domain-containing protein 8 isoform c

    See identical proteins and their annotated locations for NP_001171832.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate exon in the 3' coding region, which results in a frameshift compared to variant 1. This results in a shorter protein (isoform c), compared to isoform a. Variants 4 and 5 encode the same isoform (c).
    Source sequence(s)
    AC011466, AF322184, AK297045, BC046136, CA448628
    Consensus CDS
    CCDS54288.1
    UniProtKB/Swiss-Prot
    Q9Y2G2
    Related
    ENSP00000430747.1, ENST00000520015.5
    Conserved Domains (1) summary
    pfam13553
    Location:182 → 387
    FIIND; Function to find

  5. NM_001184904.1 → NP_001171833.1  caspase recruitment domain-containing protein 8 isoform d

    See identical proteins and their annotated locations for NP_001171833.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, 3' coding region, and 3' UTR compared to variant 1. The resulting isoform (d) is shorter than isoform a.
    Source sequence(s)
    AC011466, AI040349, BC046136, DC404273
    Consensus CDS
    CCDS54287.1
    UniProtKB/TrEMBL
    E5RFV9
    Related
    ENSP00000430108.1, ENST00000519332.5

  6. NM_001351782.2 → NP_001338711.1  caspase recruitment domain-containing protein 8 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1 and 10 encode the same protein (isoform a).
    Source sequence(s)
    AC011466, BC056891, CA448628, CB119078, DC404273, EU118120
    Consensus CDS
    CCDS54289.1
    Related
    ENSP00000428883.1, ENST00000519940.6
    Conserved Domains (2) summary
    pfam00619
    Location:453 → 535
    CARD; Caspase recruitment domain
    pfam13553
    Location:182 → 436
    FIIND; Function to find

  7. NM_001351783.2 → NP_001338712.1  caspase recruitment domain-containing protein 8 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC008392, AC011466, AF322184, AF511652, BC045539, BC056891, CA389350, CA448628, DC404273
    Consensus CDS
    CCDS12712.2
    Conserved Domains (2) summary
    pfam00619
    Location:403 → 485
    CARD; Caspase recruitment domain
    pfam13553
    Location:132 → 386
    FIIND; Function to find

  8. NM_001351784.2 → NP_001338713.1  caspase recruitment domain-containing protein 8 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF322184, AF511652, BC056891, CA448628, CR983845, DC347384, DC382648, DC404273
    Conserved Domains (2) summary
    pfam00619
    Location:348 → 430
    CARD; Caspase recruitment domain
    pfam13553
    Location:77 → 331
    FIIND; Function to find

  9. NM_001351786.2 → NP_001338715.1  caspase recruitment domain-containing protein 8 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF322184, AF511652, BC056891, CA448628, CR983845, DC382648, DC404273
    Conserved Domains (2) summary
    pfam00619
    Location:341 → 423
    CARD; Caspase recruitment domain
    pfam13553
    Location:70 → 324
    FIIND; Function to find

  10. NM_001351787.1 → NP_001338716.1  caspase recruitment domain-containing protein 8 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF143869, AK302327, DC382648, DC404273
    Conserved Domains (1) summary
    pfam13553
    Location:77 → 331
    FIIND; Function to find

  11. NM_001351788.2 → NP_001338717.1  caspase recruitment domain-containing protein 8 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF322184, AF511652, BC056891, CA448628, DC382648, DC404273
    Conserved Domains (1) summary
    pfam13553
    Location:132 → 337
    FIIND; Function to find

  12. NM_001351789.2 → NP_001338718.1  caspase recruitment domain-containing protein 8 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF322184, AF511652, BC056891, CA448628, DC382648, DC404273
    Conserved Domains (1) summary
    pfam13553
    Location:132 → 337
    FIIND; Function to find

  13. NM_001351790.2 → NP_001338719.1  caspase recruitment domain-containing protein 8 isoform i

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF322184, AF511652, BC056891, CA448628, CB119078, DC404273
    Conserved Domains (1) summary
    pfam13553
    Location:101 → 306
    FIIND; Function to find

  14. NM_001351791.2 → NP_001338720.1  caspase recruitment domain-containing protein 8 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF322184, AF511652, BC056891, CA448628, DA675182, DC382648, DC404273
    Conserved Domains (1) summary
    pfam13553
    Location:77 → 282
    FIIND; Function to find

  15. NM_001351792.2 → NP_001338721.1  caspase recruitment domain-containing protein 8 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF322184, AF511652, BC056891, CA448628, DA675182, DC347384, DC404273
    Conserved Domains (1) summary
    pfam13553
    Location:77 → 282
    FIIND; Function to find

  16. NM_001365950.1 → NP_001352879.1  caspase recruitment domain-containing protein 8 isoform k

    Status: REVIEWED

    Source sequence(s)
    AC008392, AC011466
    Conserved Domains (2) summary
    pfam00619
    Location:347 → 429
    CARD; Caspase recruitment domain
    pfam13553
    Location:77 → 330
    FIIND; Function to find

  17. NM_014959.5 → NP_055774.2  caspase recruitment domain-containing protein 8 isoform b

    See identical proteins and their annotated locations for NP_055774.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a. Variants 2, 3 and 11 encode the same isoform (b).
    Source sequence(s)
    AC011466, AF322184, AF511652, BC045539, BC056891, CA389350, CA448628, DC404273
    Consensus CDS
    CCDS12712.2
    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (2) summary
    pfam00619
    Location:403 → 485
    CARD; Caspase recruitment domain
    pfam13553
    Location:132 → 386
    FIIND; Function to find

RNA

  1. NR_033678.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC011466, AF322184, CA448628
    Related
    ENST00000518622.5

  2. NR_033679.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC011466, BC056891, CA448628, EU118121

  3. NR_033680.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC011466, AF511652, CA448628

  4. NR_147707.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011466, AF143869, AK302327, DC347384, DC404273

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    48203148..48256264 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026485.1 → XP_016881974.1  caspase recruitment domain-containing protein 8 isoform X6

  2. XM_011526650.2 → XP_011524952.1  caspase recruitment domain-containing protein 8 isoform X14

    See identical proteins and their annotated locations for XP_011524952.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (1) summary
    pfam13553
    Location:182 → 387
    FIIND; Function to find

  3. XM_006723106.4 → XP_006723169.1  caspase recruitment domain-containing protein 8 isoform X14

    See identical proteins and their annotated locations for XP_006723169.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (1) summary
    pfam13553
    Location:182 → 387
    FIIND; Function to find

  4. XM_017026492.2 → XP_016881981.1  caspase recruitment domain-containing protein 8 isoform X16

    Conserved Domains (1) summary
    pfam13553
    Location:132 → 337
    FIIND; Function to find

  5. XM_006723097.4 → XP_006723160.1  caspase recruitment domain-containing protein 8 isoform X3

    See identical proteins and their annotated locations for XP_006723160.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Related
    ENSP00000427858.1, ENST00000521613.5
    Conserved Domains (2) summary
    pfam00619
    Location:403 → 485
    CARD; Caspase recruitment domain
    pfam13553
    Location:132 → 386
    FIIND; Function to find

  6. XM_024451421.1 → XP_024307189.1  caspase recruitment domain-containing protein 8 isoform X8

    Conserved Domains (2) summary
    pfam00619
    Location:372 → 454
    CARD; Caspase recruitment domain
    pfam13553
    Location:101 → 355
    FIIND; Function to find

  7. XM_017026498.1 → XP_016881987.1  caspase recruitment domain-containing protein 8 isoform X17

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (1) summary
    pfam13553
    Location:77 → 281
    FIIND; Function to find

  8. XM_006723109.3 → XP_006723172.1  caspase recruitment domain-containing protein 8 isoform X17

    See identical proteins and their annotated locations for XP_006723172.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (1) summary
    pfam13553
    Location:77 → 281
    FIIND; Function to find

  9. XM_006723104.3 → XP_006723167.1  caspase recruitment domain-containing protein 8 isoform X11

    See identical proteins and their annotated locations for XP_006723167.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    UniProtKB/TrEMBL
    A0A024QZD3
    Conserved Domains (2) summary
    pfam00619
    Location:347 → 429
    CARD; Caspase recruitment domain
    pfam13553
    Location:77 → 330
    FIIND; Function to find

  10. XM_006723098.3 → XP_006723161.1  caspase recruitment domain-containing protein 8 isoform X8

    See identical proteins and their annotated locations for XP_006723161.1

    Conserved Domains (2) summary
    pfam00619
    Location:372 → 454
    CARD; Caspase recruitment domain
    pfam13553
    Location:101 → 355
    FIIND; Function to find

  11. XM_006723107.3 → XP_006723170.1  caspase recruitment domain-containing protein 8 isoform X15

    See identical proteins and their annotated locations for XP_006723170.1

    Conserved Domains (1) summary
    pfam13553
    Location:182 → 348
    FIIND; Function to find

  12. XM_017026499.1 → XP_016881988.1  caspase recruitment domain-containing protein 8 isoform X18

  13. XM_017026484.2 → XP_016881973.1  caspase recruitment domain-containing protein 8 isoform X4

  14. XM_017026482.2 → XP_016881971.1  caspase recruitment domain-containing protein 8 isoform X2

    Conserved Domains (2) summary
    pfam00619
    Location:452 → 534
    CARD; Caspase recruitment domain
    pfam13553
    Location:182 → 435
    FIIND; Function to find

  15. XM_024451422.1 → XP_024307190.1  caspase recruitment domain-containing protein 8 isoform X9

    Conserved Domains (2) summary
    pfam00619
    Location:371 → 453
    CARD; Caspase recruitment domain
    pfam13553
    Location:101 → 354
    FIIND; Function to find

  16. XM_011526648.3 → XP_011524950.1  caspase recruitment domain-containing protein 8 isoform X7

    Conserved Domains (2) summary
    pfam00619
    Location:379 → 461
    CARD; Caspase recruitment domain
    pfam13553
    Location:109 → 362
    FIIND; Function to find

  17. XM_006723094.4 → XP_006723157.1  caspase recruitment domain-containing protein 8 isoform X2

    Conserved Domains (2) summary
    pfam00619
    Location:452 → 534
    CARD; Caspase recruitment domain
    pfam13553
    Location:182 → 435
    FIIND; Function to find

  18. XM_017026483.2 → XP_016881972.1  caspase recruitment domain-containing protein 8 isoform X3

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (2) summary
    pfam00619
    Location:403 → 485
    CARD; Caspase recruitment domain
    pfam13553
    Location:132 → 386
    FIIND; Function to find

  19. XM_006723096.4 → XP_006723159.1  caspase recruitment domain-containing protein 8 isoform X3

    See identical proteins and their annotated locations for XP_006723159.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Related
    ENSP00000428736.1, ENST00000520153.5
    Conserved Domains (2) summary
    pfam00619
    Location:403 → 485
    CARD; Caspase recruitment domain
    pfam13553
    Location:132 → 386
    FIIND; Function to find

  20. XM_011526643.3 → XP_011524945.1  caspase recruitment domain-containing protein 8 isoform X1

    See identical proteins and their annotated locations for XP_011524945.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (2) summary
    pfam00619
    Location:453 → 535
    CARD; Caspase recruitment domain
    pfam13553
    Location:182 → 436
    FIIND; Function to find

  21. XM_006723092.4 → XP_006723155.1  caspase recruitment domain-containing protein 8 isoform X1

    See identical proteins and their annotated locations for XP_006723155.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (2) summary
    pfam00619
    Location:453 → 535
    CARD; Caspase recruitment domain
    pfam13553
    Location:182 → 436
    FIIND; Function to find

  22. XM_011526641.3 → XP_011524943.1  caspase recruitment domain-containing protein 8 isoform X1

    See identical proteins and their annotated locations for XP_011524943.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (2) summary
    pfam00619
    Location:453 → 535
    CARD; Caspase recruitment domain
    pfam13553
    Location:182 → 436
    FIIND; Function to find

  23. XM_006723093.4 → XP_006723156.1  caspase recruitment domain-containing protein 8 isoform X1

    See identical proteins and their annotated locations for XP_006723156.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (2) summary
    pfam00619
    Location:453 → 535
    CARD; Caspase recruitment domain
    pfam13553
    Location:182 → 436
    FIIND; Function to find

  24. XM_011526647.3 → XP_011524949.1  caspase recruitment domain-containing protein 8 isoform X5

    See identical proteins and their annotated locations for XP_011524949.1

    Conserved Domains (2) summary
    pfam00619
    Location:380 → 462
    CARD; Caspase recruitment domain
    pfam13553
    Location:109 → 363
    FIIND; Function to find

  25. XM_011526646.3 → XP_011524948.1  caspase recruitment domain-containing protein 8 isoform X5

    See identical proteins and their annotated locations for XP_011524948.1

    Conserved Domains (2) summary
    pfam00619
    Location:380 → 462
    CARD; Caspase recruitment domain
    pfam13553
    Location:109 → 363
    FIIND; Function to find

  26. XM_017026488.2 → XP_016881977.1  caspase recruitment domain-containing protein 8 isoform X13

    Conserved Domains (2) summary
    pfam00619
    Location:341 → 423
    CARD; Caspase recruitment domain
    pfam13553
    Location:70 → 324
    FIIND; Function to find

  27. XM_024451423.1 → XP_024307191.1  caspase recruitment domain-containing protein 8 isoform X10

    Conserved Domains (2) summary
    pfam00619
    Location:348 → 430
    CARD; Caspase recruitment domain
    pfam13553
    Location:77 → 331
    FIIND; Function to find

  28. XM_024451425.1 → XP_024307193.1  caspase recruitment domain-containing protein 8 isoform X12

    Conserved Domains (2) summary
    pfam00619
    Location:343 → 425
    CARD; Caspase recruitment domain
    pfam13553
    Location:72 → 326
    FIIND; Function to find

  29. XM_006723102.4 → XP_006723165.1  caspase recruitment domain-containing protein 8 isoform X10

    See identical proteins and their annotated locations for XP_006723165.1

    Conserved Domains (2) summary
    pfam00619
    Location:348 → 430
    CARD; Caspase recruitment domain
    pfam13553
    Location:77 → 331
    FIIND; Function to find

  30. XM_006723091.4 → XP_006723154.1  caspase recruitment domain-containing protein 8 isoform X1

    See identical proteins and their annotated locations for XP_006723154.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (2) summary
    pfam00619
    Location:453 → 535
    CARD; Caspase recruitment domain
    pfam13553
    Location:182 → 436
    FIIND; Function to find

  31. XM_024451424.1 → XP_024307192.1  caspase recruitment domain-containing protein 8 isoform X12

    Conserved Domains (2) summary
    pfam00619
    Location:343 → 425
    CARD; Caspase recruitment domain
    pfam13553
    Location:72 → 326
    FIIND; Function to find

  32. XM_011526644.3 → XP_011524946.1  caspase recruitment domain-containing protein 8 isoform X1

    See identical proteins and their annotated locations for XP_011524946.1

    UniProtKB/Swiss-Prot
    Q9Y2G2
    Conserved Domains (2) summary
    pfam00619
    Location:453 → 535
    CARD; Caspase recruitment domain
    pfam13553
    Location:182 → 436
    FIIND; Function to find

  33. XM_017026487.2 → XP_016881976.1  caspase recruitment domain-containing protein 8 isoform X13

    Conserved Domains (2) summary
    pfam00619
    Location:341 → 423
    CARD; Caspase recruitment domain
    pfam13553
    Location:70 → 324
    FIIND; Function to find

  34. XM_006723110.3 → XP_006723173.1  caspase recruitment domain-containing protein 8 isoform X19

    See identical proteins and their annotated locations for XP_006723173.1

    UniProtKB/TrEMBL
    E5RFV9
    Related
    ENSP00000427727.1, ENST00000520007.5

RNA

  1. XR_001753637.2 RNA Sequence

  2. XR_001753636.1 RNA Sequence

  3. XR_430193.3 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y2G2.1 GenPept UniProtKB/Swiss-Prot:Q9Y2G2

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