Format

Send to:

Choose Destination

ARHGEF15 Rho guanine nucleotide exchange factor 15 [ Homo sapiens (human) ]

Gene ID: 22899, updated on 7-Jun-2020

Summary

Official Symbol
ARHGEF15provided by HGNC
Official Full Name
Rho guanine nucleotide exchange factor 15provided by HGNC
Primary source
HGNC:HGNC:15590
See related
Ensembl:ENSG00000198844 MIM:608504
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
E5; ARGEF15; Ephexin5; Vsm-RhoGEF
Summary
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. This gene encodes a protein that functions as a specific guanine nucleotide exchange factor for RhoA. It also interacts with ephrin A4 in vascular smooth muscle cells. Two alternatively spliced transcripts variants that encode the same protein have been found for this gene. [provided by RefSeq, Aug 2010]
Expression
Broad expression in fat (RPKM 15.9), lung (RPKM 13.8) and 19 other tissues See more
Orthologs

Genomic context

See ARHGEF15 in Genome Data Viewer
Location:
17p13.1
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (8310241..8322516)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8213556..8225834)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 35 Neighboring gene RAN guanine nucleotide release factor Neighboring gene CRISPRi-validated cis-regulatory element chr17.641 Neighboring gene outer dense fiber of sperm tails 4 Neighboring gene uncharacterized LOC100128288 Neighboring gene KRAB-A domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13791, KIAA0915, MGC44868

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
Rho guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rho guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
Rho guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of synapse maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of stress fiber assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of catalytic activity IDA
Inferred from Direct Assay
more info
PubMed 
retina vasculature morphogenesis in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
rho guanine nucleotide exchange factor 15
Names
Rho guanine nucleotide exchange factor (GEF) 15
ephexin-5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034063.1 RefSeqGene

    Range
    5004..17274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_025014.1NP_079290.1  rho guanine nucleotide exchange factor 15

    See identical proteins and their annotated locations for NP_079290.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a different segment for its 5' UTR, compared to variant 1. It encodes the same protein as variant 1.
    Source sequence(s)
    AB020722, BQ004849, BQ877184, DA632576
    Consensus CDS
    CCDS11139.1
    UniProtKB/Swiss-Prot
    O94989
    UniProtKB/TrEMBL
    A0A0S2Z547
    Related
    ENSP00000412505.1, ENST00000421050.2
    Conserved Domains (2) summary
    cd01221
    Location:622742
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:422598
    RhoGEF; RhoGEF domain
  2. NM_173728.4NP_776089.2  rho guanine nucleotide exchange factor 15

    See identical proteins and their annotated locations for NP_776089.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer transcript. It encodes the same protein as variant 2.
    Source sequence(s)
    AB020722, BC036749, BQ877184, DB279954
    Consensus CDS
    CCDS11139.1
    UniProtKB/Swiss-Prot
    O94989
    UniProtKB/TrEMBL
    A0A0S2Z547
    Related
    ENSP00000355026.3, ENST00000361926.8
    Conserved Domains (2) summary
    cd01221
    Location:622742
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:422598
    RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    8310241..8322516
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523734.2XP_011522036.1  rho guanine nucleotide exchange factor 15 isoform X1

    See identical proteins and their annotated locations for XP_011522036.1

    Conserved Domains (2) summary
    cd01221
    Location:637757
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:422613
    RhoGEF; RhoGEF domain
  2. XM_011523736.2XP_011522038.1  rho guanine nucleotide exchange factor 15 isoform X2

    Conserved Domains (2) summary
    pfam00621
    Location:422613
    RhoGEF; RhoGEF domain
    cl17171
    Location:637699
    PH-like; Pleckstrin homology-like domain
  3. XM_011523735.1XP_011522037.1  rho guanine nucleotide exchange factor 15 isoform X1

    See identical proteins and their annotated locations for XP_011522037.1

    Conserved Domains (2) summary
    cd01221
    Location:637757
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:422613
    RhoGEF; RhoGEF domain
  4. XM_011523737.1XP_011522039.1  rho guanine nucleotide exchange factor 15 isoform X3

    Conserved Domains (2) summary
    cd01221
    Location:220340
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:5196
    RhoGEF; RhoGEF domain
Support Center