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CEP164 centrosomal protein 164 [ Homo sapiens (human) ]

Gene ID: 22897, updated on 25-Nov-2025
Official Symbol
CEP164provided by HGNC
Official Full Name
centrosomal protein 164provided by HGNC
Primary source
HGNC:HGNC:29182
See related
Ensembl:ENSG00000110274 MIM:614848; AllianceGenome:HGNC:29182
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NPHP15
Summary
This gene encodes a centrosomal protein involved in microtubule organization, DNA damage response, and chromosome segregation. The encoded protein is required for assembly of primary cilia and localizes to mature centrioles. Defects in this gene are a cause of nephronophthisis-related ciliopathies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Expression
Broad expression in testis (RPKM 9.7), endometrium (RPKM 3.1) and 25 other tissues See more
Orthologs
mouse all
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Try the new Transcript table
See CEP164 in Genome Data Viewer
Location:
11q23.3
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (117321778..117413266)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (117338426..117429915)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (117192494..117283982)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene small Cajal body-specific RNA 11 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:117139693-117140239 Neighboring gene ring finger protein 214 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:117159860-117161059 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:117170345-117170906 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:117170907-117171468 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117184838-117185360 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117185361-117185882 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3937 Neighboring gene BACE1 antisense RNA Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3938 Neighboring gene beta-secretase 1 Neighboring gene proline rich 13 pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117251903-117252429 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117252430-117252955 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117253123-117253624 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117282701-117283213 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117290977-117291477 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117300124-117300802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117300803-117301480 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117301481-117302158 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5571 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117308425-117309399 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:117313272-117314252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117335195-117335696 Neighboring gene DS cell adhesion molecule like 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117353337-117353840 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117353841-117354343 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117360661-117361161 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117365669-117366170 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117382135-117383118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117385871-117386470 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117392233-117393054 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117417610-117418130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117418131-117418651 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117427703-117428575 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117428576-117429447 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117430072-117430572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117430573-117431073 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117463869-117464660 Neighboring gene MPRA-validated peak1488 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117471363-117472111 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117482895-117483428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117488029-117488528 Neighboring gene uncharacterized LOC105369515 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117533497-117534182 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117539691-117540527 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:117549982-117550688 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:117550689-117551396 Neighboring gene NANOG hESC enhancer GRCh37_chr11:117594511-117595039 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117629849-117630350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117630351-117630850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117651403-117651902 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5573 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5574 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:117684525-117685102 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5575 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117689832-117690566 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117690567-117691301 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117692983-117693536 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117695199-117695752 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117695753-117696305 Neighboring gene FXYD6-FXYD2 readthrough Neighboring gene FXYD domain containing ion transport regulator 2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. CEP164-null cells generated by genome editing show a ciliation defect with intact DNA repair capacity. Daly OM, et al. J Cell Sci, 2016 May 1. PMID 26966185
  2. Cep164 mediates vesicular docking to the mother centriole during early steps of ciliogenesis. Schmidt KN, et al. J Cell Biol, 2012 Dec 24. PMID 23253480, Free PMC Article
  3. Biallelic variants in CEP164 cause a motile ciliopathy-like syndrome. Devlin LA, et al. Clin Genet, 2023 Mar. PMID 36273371, Free PMC Article
  4. Assigning functions to genes: identification of S-phase expressed genes in Leishmania major based on post-transcriptional control elements. Zick A, et al. Nucleic Acids Res, 2005. PMID 16052032, Free PMC Article
  5. Molecular mechanisms underlying the role of the centriolar CEP164-TTBK2 complex in ciliopathies. Rosa E Silva I, et al. Structure, 2022 Jan 6. PMID 34499853, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Biallelic variants in CEP164 cause a motile ciliopathy-like syndrome.
    Title: Biallelic variants in CEP164 cause a motile ciliopathy-like syndrome.
  2. Molecular mechanisms underlying the role of the centriolar CEP164-TTBK2 complex in ciliopathies.
    Title: Molecular mechanisms underlying the role of the centriolar CEP164-TTBK2 complex in ciliopathies.
  3. these data support a conserved role for CEP164 throughout the development of numerous organs, which, we suggest, accounts for the multi-system disease phenotype of CEP164-mediated Nephronophthisis-related ciliopathies
    Title: Embryonic and foetal expression patterns of the ciliopathy gene CEP164.
  4. data suggest that CEP164 is not required in the DNA damage response.
    Title: CEP164-null cells generated by genome editing show a ciliation defect with intact DNA repair capacity.
  5. This study reveals a novel role for CEP164 in the pathogenesis of nephronophthisis, in which mutations cause ciliary defects coupled with DNA damage induced replicative stress, cell death, and epithelial-to-mesenchymal transition
    Title: Nephronophthisis-associated CEP164 regulates cell cycle progression, apoptosis and epithelial-to-mesenchymal transition.
  6. Evidence is provided that TTBK2 effectively phosphorylate Cep164 and Cep97 and inhibits the interaction between Cep164 and its binding partner Dishevelled-3 (an important regulator of ciliogenesis) in a kinase activity-dependent manner.
    Title: Binding to Cep164, but not EB1, is essential for centriolar localization of TTBK2 and its function in ciliogenesis.
  7. data suggest that TTBK2 also acts upstream of Cep164, contributing to the assembly of distal appendages
    Title: Cep164 triggers ciliogenesis by recruiting Tau tubulin kinase 2 to the mother centriole.
  8. Cep164 is targeted to the apical domain of the mother centriole to provide the molecular link between the mother centriole and the membrane biogenesis machinery that initiates cilia formation.
    Title: Cep164 mediates vesicular docking to the mother centriole during early steps of ciliogenesis.
  9. findings indicate that ARL13B, INPP5E, PDE6D, and CEP164 form a distinct functional network that is involved in JBTS and NPHP but independent of the ones previously defined by NPHP and MKS proteins
    Title: ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting.
  10. Study identifies by whole-exome resequencing, mutations of MRE11, ZNF423, and CEP164 as causing Nephronophthisis-related ciliopathies.
    Title: Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Nephronophthisis
MedGen: C0687120 GeneReviews: Nephronophthisis-Related Ciliopathies
not available
Nephronophthisis 15
MedGen: C3541853 OMIM: 614845 GeneReviews: Nephronophthisis-Related Ciliopathies
not available
Retinitis pigmentosa 1
MedGen: C0220701 OMIM: 180100 GeneReviews: Nonsyndromic Retinitis Pigmentosa Overview
not available

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ54767, KIAA1052

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ciliary transition fiber IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ciliary transition fiber IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ciliary transition fiber IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular space HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
centrosomal protein of 164 kDa
Names
centrosomal protein 164kDa

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033032.1 RefSeqGene

    Range
    11077..96489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001271933.2 → NP_001258862.1  centrosomal protein of 164 kDa isoform 2

    See identical proteins and their annotated locations for NP_001258862.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, uses an alternate in-frame splice site at the 3' end of an exon, and uses an alternate in-frame splice site at the 5' end of an exon compared to variant 1. The resulting isoform (2) contains an alternate internal segment and lacks another alternate internal segment compared to isoform 1.
    Source sequence(s)
    AB028975, AL833532, AP001822
    UniProtKB/Swiss-Prot
    Q9UPV0
    Conserved Domains (5) summary
    cd00201
    Location:59 → 89
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam15665
    Location:694 → 903
    FAM184; Family with sequence similarity 184, A and B
    cd16269
    Location:927 → 946
    GBP_C; coiled coil [structural motif]
    cl00144
    Location:686 → 771
    Tar_Tsr_LBD; ligand binding domain of Tar- and Tsr-related chemoreceptors
    cl20817
    Location:795 → 966
    GBP_C; Guanylate-binding protein, C-terminal domain

  2. NM_001440949.1 → NP_001427878.1  centrosomal protein of 164 kDa isoform 3

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  3. NM_001440950.1 → NP_001427879.1  centrosomal protein of 164 kDa isoform 1

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822
    UniProtKB/Swiss-Prot
    Q6PKH9, Q7Z2X9, Q9NVS0, Q9UFJ6, Q9UPV0

  4. NM_001440951.1 → NP_001427880.1  centrosomal protein of 164 kDa isoform 1

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822
    UniProtKB/Swiss-Prot
    Q6PKH9, Q7Z2X9, Q9NVS0, Q9UFJ6, Q9UPV0

  5. NM_001440952.1 → NP_001427881.1  centrosomal protein of 164 kDa isoform 4

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  6. NM_001440953.1 → NP_001427882.1  centrosomal protein of 164 kDa isoform 5

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  7. NM_001440954.1 → NP_001427883.1  centrosomal protein of 164 kDa isoform 6

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  8. NM_001440955.1 → NP_001427884.1  centrosomal protein of 164 kDa isoform 6

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822
    Related
    ENSP00000627829.1, ENST00000957770.1

  9. NM_001440956.1 → NP_001427885.1  centrosomal protein of 164 kDa isoform 7

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  10. NM_001440957.1 → NP_001427886.1  centrosomal protein of 164 kDa isoform 8

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  11. NM_001440958.1 → NP_001427887.1  centrosomal protein of 164 kDa isoform 9

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  12. NM_001440959.1 → NP_001427888.1  centrosomal protein of 164 kDa isoform 9

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  13. NM_001440960.1 → NP_001427889.1  centrosomal protein of 164 kDa isoform 10

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  14. NM_001440961.1 → NP_001427890.1  centrosomal protein of 164 kDa isoform 11

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  15. NM_001440962.1 → NP_001427891.1  centrosomal protein of 164 kDa isoform 12

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  16. NM_001440963.1 → NP_001427892.1  centrosomal protein of 164 kDa isoform 12

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  17. NM_001440964.1 → NP_001427893.1  centrosomal protein of 164 kDa isoform 13

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  18. NM_001440965.1 → NP_001427894.1  centrosomal protein of 164 kDa isoform 13

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  19. NM_001440966.1 → NP_001427895.1  centrosomal protein of 164 kDa isoform 13

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  20. NM_001440967.1 → NP_001427896.1  centrosomal protein of 164 kDa isoform 14

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  21. NM_001440968.1 → NP_001427897.1  centrosomal protein of 164 kDa isoform 15

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  22. NM_001440969.1 → NP_001427898.1  centrosomal protein of 164 kDa isoform 16

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  23. NM_001440970.1 → NP_001427899.1  centrosomal protein of 164 kDa isoform 17

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  24. NM_001440971.1 → NP_001427900.1  centrosomal protein of 164 kDa isoform 18

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  25. NM_001440972.1 → NP_001427901.1  centrosomal protein of 164 kDa isoform 19

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  26. NM_001440973.1 → NP_001427902.1  centrosomal protein of 164 kDa isoform 20

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  27. NM_001440974.1 → NP_001427903.1  centrosomal protein of 164 kDa isoform 20

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  28. NM_001440975.1 → NP_001427904.1  centrosomal protein of 164 kDa isoform 20

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822
    Related
    ENSP00000610028.1, ENST00000939969.1

  29. NM_001440976.1 → NP_001427905.1  centrosomal protein of 164 kDa isoform 21

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  30. NM_001440977.1 → NP_001427906.1  centrosomal protein of 164 kDa isoform 21

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  31. NM_001440978.1 → NP_001427907.1  centrosomal protein of 164 kDa isoform 22

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  32. NM_001440979.1 → NP_001427908.1  centrosomal protein of 164 kDa isoform 23

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  33. NM_001440980.1 → NP_001427909.1  centrosomal protein of 164 kDa isoform 23

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  34. NM_001440981.1 → NP_001427910.1  centrosomal protein of 164 kDa isoform 23

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  35. NM_001440982.1 → NP_001427911.1  centrosomal protein of 164 kDa isoform 24

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  36. NM_001440983.1 → NP_001427912.1  centrosomal protein of 164 kDa isoform 25

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  37. NM_001440984.1 → NP_001427913.1  centrosomal protein of 164 kDa isoform 26

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822
    Related
    ENSP00000610027.1, ENST00000939968.1

  38. NM_001440987.1 → NP_001427916.1  centrosomal protein of 164 kDa isoform 27

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  39. NM_001440990.1 → NP_001427919.1  centrosomal protein of 164 kDa isoform 28

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  40. NM_001440992.1 → NP_001427921.1  centrosomal protein of 164 kDa isoform 29

    Status: REVIEWED

    Source sequence(s)
    AP000892, AP001822

  41. NM_014956.5 → NP_055771.4  centrosomal protein of 164 kDa isoform 1

    See identical proteins and their annotated locations for NP_055771.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB028975, AL833532, AP000892, AP001822, BX648682
    Consensus CDS
    CCDS31683.1
    UniProtKB/Swiss-Prot
    Q6PKH9, Q7Z2X9, Q9NVS0, Q9UFJ6, Q9UPV0
    Related
    ENSP00000278935.3, ENST00000278935.8
    Conserved Domains (5) summary
    cd00201
    Location:59 → 89
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam15665
    Location:691 → 900
    FAM184; Family with sequence similarity 184, A and B
    cd16269
    Location:924 → 943
    GBP_C; coiled coil [structural motif]
    cl00144
    Location:683 → 768
    Tar_Tsr_LBD; ligand binding domain of Tar- and Tsr-related chemoreceptors
    cl20817
    Location:792 → 963
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    117321778..117413266
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718788.2 → XP_006718851.1  centrosomal protein of 164 kDa isoform X5

    Conserved Domains (6) summary
    cd00201
    Location:59 → 89
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam09731
    Location:1024 → 1371
    Mitofilin; Mitochondrial inner membrane protein
    pfam15665
    Location:1256 → 1465
    FAM184; Family with sequence similarity 184, A and B
    cd16269
    Location:1489 → 1508
    GBP_C; coiled coil [structural motif]
    cl00144
    Location:1248 → 1333
    Tar_Tsr_LBD; ligand binding domain of Tar- and Tsr-related chemoreceptors
    cl20817
    Location:1357 → 1528
    GBP_C; Guanylate-binding protein, C-terminal domain

  2. XM_047426570.1 → XP_047282526.1  centrosomal protein of 164 kDa isoform X8

  3. XM_047426578.1 → XP_047282534.1  centrosomal protein of 164 kDa isoform X18

  4. XM_047426581.1 → XP_047282537.1  centrosomal protein of 164 kDa isoform X21

  5. XM_047426582.1 → XP_047282538.1  centrosomal protein of 164 kDa isoform X22

  6. XM_011542674.2 → XP_011540976.1  centrosomal protein of 164 kDa isoform X1

    Conserved Domains (6) summary
    cd00201
    Location:59 → 89
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam09731
    Location:1040 → 1388
    Mitofilin; Mitochondrial inner membrane protein
    pfam15665
    Location:1273 → 1482
    FAM184; Family with sequence similarity 184, A and B
    cd16269
    Location:1506 → 1525
    GBP_C; coiled coil [structural motif]
    cl00144
    Location:1265 → 1350
    Tar_Tsr_LBD; ligand binding domain of Tar- and Tsr-related chemoreceptors
    cl20817
    Location:1374 → 1545
    GBP_C; Guanylate-binding protein, C-terminal domain

  7. XM_017017369.2 → XP_016872858.1  centrosomal protein of 164 kDa isoform X3

  8. XM_017017368.2 → XP_016872857.1  centrosomal protein of 164 kDa isoform X2

  9. XM_017017370.2 → XP_016872859.1  centrosomal protein of 164 kDa isoform X4

  10. XM_047426576.1 → XP_047282532.1  centrosomal protein of 164 kDa isoform X16

  11. XM_047426574.1 → XP_047282530.1  centrosomal protein of 164 kDa isoform X14

  12. XM_005271453.2 → XP_005271510.1  centrosomal protein of 164 kDa isoform X6

    Conserved Domains (5) summary
    cd00201
    Location:59 → 89
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam15665
    Location:1253 → 1462
    FAM184; Family with sequence similarity 184, A and B
    cd16269
    Location:1486 → 1505
    GBP_C; coiled coil [structural motif]
    cl00144
    Location:1245 → 1330
    Tar_Tsr_LBD; ligand binding domain of Tar- and Tsr-related chemoreceptors
    cl20817
    Location:1354 → 1525
    GBP_C; Guanylate-binding protein, C-terminal domain

  13. XM_047426571.1 → XP_047282527.1  centrosomal protein of 164 kDa isoform X10

  14. XM_047426569.1 → XP_047282525.1  centrosomal protein of 164 kDa isoform X7

  15. XM_047426572.1 → XP_047282528.1  centrosomal protein of 164 kDa isoform X11

  16. XM_047426579.1 → XP_047282535.1  centrosomal protein of 164 kDa isoform X19

  17. XM_047426583.1 → XP_047282539.1  centrosomal protein of 164 kDa isoform X23

  18. XM_047426580.1 → XP_047282536.1  centrosomal protein of 164 kDa isoform X20

  19. XM_047426584.1 → XP_047282540.1  centrosomal protein of 164 kDa isoform X24

  20. XM_017017371.2 → XP_016872860.1  centrosomal protein of 164 kDa isoform X9

  21. XM_017017372.2 → XP_016872861.1  centrosomal protein of 164 kDa isoform X12

  22. XM_047426575.1 → XP_047282531.1  centrosomal protein of 164 kDa isoform X15

  23. XM_047426573.1 → XP_047282529.1  centrosomal protein of 164 kDa isoform X13

  24. XM_005271457.2 → XP_005271514.1  centrosomal protein of 164 kDa isoform X27

    See identical proteins and their annotated locations for XP_005271514.1

    UniProtKB/Swiss-Prot
    Q9UPV0
    Conserved Domains (5) summary
    cd00201
    Location:59 → 89
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam15665
    Location:694 → 903
    FAM184; Family with sequence similarity 184, A and B
    cd16269
    Location:927 → 946
    GBP_C; coiled coil [structural motif]
    cl00144
    Location:686 → 771
    Tar_Tsr_LBD; ligand binding domain of Tar- and Tsr-related chemoreceptors
    cl20817
    Location:795 → 966
    GBP_C; Guanylate-binding protein, C-terminal domain

  25. XM_047426588.1 → XP_047282544.1  centrosomal protein of 164 kDa isoform X29

  26. XM_047426598.1 → XP_047282554.1  centrosomal protein of 164 kDa isoform X38

  27. XM_047426590.1 → XP_047282546.1  centrosomal protein of 164 kDa isoform X32

  28. XM_047426589.1 → XP_047282545.1  centrosomal protein of 164 kDa isoform X30

  29. XM_047426599.1 → XP_047282555.1  centrosomal protein of 164 kDa isoform X39

  30. XM_047426604.1 → XP_047282560.1  centrosomal protein of 164 kDa isoform X42

  31. XM_017017367.2 → XP_016872856.1  centrosomal protein of 164 kDa isoform X1

    Conserved Domains (6) summary
    cd00201
    Location:59 → 89
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam09731
    Location:1040 → 1388
    Mitofilin; Mitochondrial inner membrane protein
    pfam15665
    Location:1273 → 1482
    FAM184; Family with sequence similarity 184, A and B
    cd16269
    Location:1506 → 1525
    GBP_C; coiled coil [structural motif]
    cl00144
    Location:1265 → 1350
    Tar_Tsr_LBD; ligand binding domain of Tar- and Tsr-related chemoreceptors
    cl20817
    Location:1374 → 1545
    GBP_C; Guanylate-binding protein, C-terminal domain

  32. XM_047426577.1 → XP_047282533.1  centrosomal protein of 164 kDa isoform X17

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    117338426..117429915
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368056.1 → XP_054224031.1  centrosomal protein of 164 kDa isoform X5

  2. XM_054368059.1 → XP_054224034.1  centrosomal protein of 164 kDa isoform X8

  3. XM_054368069.1 → XP_054224044.1  centrosomal protein of 164 kDa isoform X18

  4. XM_054368072.1 → XP_054224047.1  centrosomal protein of 164 kDa isoform X21

  5. XM_054368073.1 → XP_054224048.1  centrosomal protein of 164 kDa isoform X22

  6. XM_054368051.1 → XP_054224026.1  centrosomal protein of 164 kDa isoform X1

  7. XM_054368054.1 → XP_054224029.1  centrosomal protein of 164 kDa isoform X3

  8. XM_054368053.1 → XP_054224028.1  centrosomal protein of 164 kDa isoform X2

  9. XM_054368055.1 → XP_054224030.1  centrosomal protein of 164 kDa isoform X4

  10. XM_054368067.1 → XP_054224042.1  centrosomal protein of 164 kDa isoform X16

  11. XM_054368065.1 → XP_054224040.1  centrosomal protein of 164 kDa isoform X14

  12. XM_054368057.1 → XP_054224032.1  centrosomal protein of 164 kDa isoform X6

  13. XM_054368061.1 → XP_054224036.1  centrosomal protein of 164 kDa isoform X10

  14. XM_054368058.1 → XP_054224033.1  centrosomal protein of 164 kDa isoform X7

  15. XM_054368062.1 → XP_054224037.1  centrosomal protein of 164 kDa isoform X11

  16. XM_054368070.1 → XP_054224045.1  centrosomal protein of 164 kDa isoform X19

  17. XM_054368074.1 → XP_054224049.1  centrosomal protein of 164 kDa isoform X23

  18. XM_054368071.1 → XP_054224046.1  centrosomal protein of 164 kDa isoform X20

  19. XM_054368075.1 → XP_054224050.1  centrosomal protein of 164 kDa isoform X24

  20. XM_054368060.1 → XP_054224035.1  centrosomal protein of 164 kDa isoform X9

  21. XM_054368063.1 → XP_054224038.1  centrosomal protein of 164 kDa isoform X12

  22. XM_054368066.1 → XP_054224041.1  centrosomal protein of 164 kDa isoform X15

  23. XM_054368064.1 → XP_054224039.1  centrosomal protein of 164 kDa isoform X13

  24. XM_054368079.1 → XP_054224054.1  centrosomal protein of 164 kDa isoform X27

  25. XM_054368081.1 → XP_054224056.1  centrosomal protein of 164 kDa isoform X29

  26. XM_054368092.1 → XP_054224067.1  centrosomal protein of 164 kDa isoform X38

  27. XM_054368084.1 → XP_054224059.1  centrosomal protein of 164 kDa isoform X32

  28. XM_054368082.1 → XP_054224057.1  centrosomal protein of 164 kDa isoform X30

  29. XM_054368093.1 → XP_054224068.1  centrosomal protein of 164 kDa isoform X39

  30. XM_054368098.1 → XP_054224073.1  centrosomal protein of 164 kDa isoform X42

  31. XM_054368052.1 → XP_054224027.1  centrosomal protein of 164 kDa isoform X1

  32. XM_054368068.1 → XP_054224043.1  centrosomal protein of 164 kDa isoform X17

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UPV0.3 GenPept UniProtKB/Swiss-Prot:Q9UPV0

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