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Stx16 syntaxin 16 [ Mus musculus (house mouse) ]

Gene ID: 228960, updated on 9-Mar-2023

Summary

Official Symbol
Stx16provided by MGI
Official Full Name
syntaxin 16provided by MGI
Primary source
MGI:MGI:1923396
See related
Ensembl:ENSMUSG00000027522 AllianceGenome:MGI:1923396
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Syn16; 4930401D03; 5430410K23Rik; 6330500A18Rik
Summary
Predicted to enable SNAP receptor activity and syntaxin binding activity. Predicted to be involved in several processes, including Golgi ribbon formation; retrograde transport, endosome to Golgi; and vesicle docking. Predicted to act upstream of or within protein transport. Located in Golgi apparatus. Is expressed in several structures, including central nervous system; connective tissue; genitourinary system; gut; and immune system. Human ortholog(s) of this gene implicated in pseudohypoparathyroidism type IB. Orthologous to human STX16 (syntaxin 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 23.8), CNS E11.5 (RPKM 23.2) and 28 other tissues See more
Orthologs
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Genomic context

See Stx16 in Genome Data Viewer
Location:
2; 2 H4
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (173918052..173941564)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (174076260..174099771)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 30143 Neighboring gene vesicle-associated membrane protein 7, pseudogene Neighboring gene aminopeptidase-like 1 Neighboring gene predicted gene 10714

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SNAP receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables syntaxin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in endocytic recycling ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi cisterna ISO
Inferred from Sequence Orthology
more info
 
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SNARE complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102423.1NP_001095893.1  syntaxin-16 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    BC095989, BP763202, BY122006, CX123636
    Related
    ENSMUSP00000039543.7, ENSMUST00000044638.13
    Conserved Domains (2) summary
    cd15845
    Location:230288
    SNARE_syntaxin16; SNARE motif of syntaxin 16
    cl00143
    Location:76190
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
  2. NM_001102424.1NP_001095894.1  syntaxin-16 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    BC094436, BC095989, BP763202, BY122006
    UniProtKB/TrEMBL
    Q0VGN4
    Conserved Domains (2) summary
    cd15845
    Location:217275
    SNARE_syntaxin16; SNARE motif of syntaxin 16
    cl00143
    Location:63177
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
  3. NM_001102425.1NP_001095895.1  syntaxin-16 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice junction and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (d) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    BC095989, BP763202, BY125296
    UniProtKB/TrEMBL
    A0A8C6I980
    Conserved Domains (2) summary
    cd15845
    Location:213271
    SNARE_syntaxin16; SNARE motif of syntaxin 16
    cl00143
    Location:59173
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
  4. NM_001363029.1NP_001349958.1  syntaxin-16 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (e) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AL669896
    Related
    ENSMUSP00000116618.2, ENSMUST00000156054.2
    Conserved Domains (2) summary
    cl22856
    Location:217244
    SNARE; SNARE motif
    cl26014
    Location:73254
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
  5. NM_001363030.1NP_001349959.1  syntaxin-16 isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (f) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AK029571, AL669896
    UniProtKB/TrEMBL
    Q8C0W8
    Conserved Domains (2) summary
    COG5325
    Location:20249
    COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
    cd15845
    Location:181239
    SNARE_syntaxin16; SNARE motif of syntaxin 16
  6. NM_001363031.1NP_001349960.1  syntaxin-16 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (g) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AL669896
    Conserved Domains (2) summary
    COG5325
    Location:19186
    COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
    cd15845
    Location:118176
    SNARE_syntaxin16; SNARE motif of syntaxin 16
  7. NM_172675.4NP_766263.2  syntaxin-16 isoform a

    See identical proteins and their annotated locations for NP_766263.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    BC095989, BP763202, BY122006
    Consensus CDS
    CCDS17147.2
    UniProtKB/Swiss-Prot
    A2ACM7, Q8BVI5
    UniProtKB/TrEMBL
    A0A8C6I997
    Related
    ENSMUSP00000085218.4, ENSMUST00000087908.10
    Conserved Domains (2) summary
    cd15845
    Location:234292
    SNARE_syntaxin16; SNARE motif of syntaxin 16
    cl00143
    Location:80194
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...

RNA

  1. NR_156433.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL669896

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    173918052..173941564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499440.5XP_006499503.1  syntaxin-16 isoform X2

    Conserved Domains (2) summary
    COG5325
    Location:19186
    COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
    cd15845
    Location:118176
    SNARE_syntaxin16; SNARE motif of syntaxin 16
  2. XM_030250767.2XP_030106627.1  syntaxin-16 isoform X2

    Conserved Domains (2) summary
    COG5325
    Location:19186
    COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
    cd15845
    Location:118176
    SNARE_syntaxin16; SNARE motif of syntaxin 16
  3. XM_030250772.2XP_030106632.1  syntaxin-16 isoform X2

    Conserved Domains (2) summary
    COG5325
    Location:19186
    COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
    cd15845
    Location:118176
    SNARE_syntaxin16; SNARE motif of syntaxin 16
  4. XM_006499437.4XP_006499500.1  syntaxin-16 isoform X1

    See identical proteins and their annotated locations for XP_006499500.1

    UniProtKB/TrEMBL
    Q8C0W8
    Conserved Domains (2) summary
    COG5325
    Location:20249
    COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
    cd15845
    Location:181239
    SNARE_syntaxin16; SNARE motif of syntaxin 16
  5. XM_006499439.4XP_006499502.1  syntaxin-16 isoform X1

    See identical proteins and their annotated locations for XP_006499502.1

    UniProtKB/TrEMBL
    Q8C0W8
    Conserved Domains (2) summary
    COG5325
    Location:20249
    COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
    cd15845
    Location:181239
    SNARE_syntaxin16; SNARE motif of syntaxin 16
  6. XM_006499436.4XP_006499499.1  syntaxin-16 isoform X1

    See identical proteins and their annotated locations for XP_006499499.1

    UniProtKB/TrEMBL
    Q8C0W8
    Conserved Domains (2) summary
    COG5325
    Location:20249
    COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
    cd15845
    Location:181239
    SNARE_syntaxin16; SNARE motif of syntaxin 16
  7. XM_006499438.4XP_006499501.1  syntaxin-16 isoform X1

    See identical proteins and their annotated locations for XP_006499501.1

    UniProtKB/TrEMBL
    Q8C0W8
    Conserved Domains (2) summary
    COG5325
    Location:20249
    COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
    cd15845
    Location:181239
    SNARE_syntaxin16; SNARE motif of syntaxin 16
  8. XM_030250771.1XP_030106631.1  syntaxin-16 isoform X2

    Conserved Domains (2) summary
    COG5325
    Location:19186
    COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
    cd15845
    Location:118176
    SNARE_syntaxin16; SNARE motif of syntaxin 16