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DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease [ Homo sapiens (human) ]

Gene ID: 22894, updated on 27-Nov-2024

Summary

Official Symbol
DIS3provided by HGNC
Official Full Name
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonucleaseprovided by HGNC
Primary source
HGNC:HGNC:20604
See related
Ensembl:ENSG00000083520 MIM:607533; AllianceGenome:HGNC:20604
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RRP44; dis3p; EXOSC11; KIAA1008; 2810028N01Rik
Summary
Enables 3'-5'-RNA exonuclease activity; endonuclease activity; and guanyl-nucleotide exchange factor activity. Involved in CUT catabolic process; RNA processing; and rRNA catabolic process. Located in cytosol and nucleoplasm. Part of nuclear exosome (RNase complex). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis (RPKM 10.1), lymph node (RPKM 7.2) and 25 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See DIS3 in Genome Data Viewer
Location:
13q21.33
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (72752169..72781900, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (71973643..72003383, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (73326307..73356038, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 80, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr13:73301228-73301409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5395 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7814 Neighboring gene mitotic spindle organizing protein 1 Neighboring gene BORA aurora kinase A activator Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:73355230-73356144 Neighboring gene progesterone immunomodulatory binding factor 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:73426017-73426548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:73426549-73427078 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7816 Neighboring gene RNA, U6 small nuclear 79, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr13:73509249-73509443 Neighboring gene NANOG hESC enhancer GRCh37_chr13:73534622-73535123 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:73610339-73611015 Neighboring gene proteasome 26S subunit, non-ATPase, 10 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ10484, MGC33035, DKFZp667L1817

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 3'-5'-RNA exonuclease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables 3'-5'-RNA exonuclease activity TAS
Traceable Author Statement
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables endonuclease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in CUT catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in RNA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in RNA processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nuclear mRNA surveillance of mRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS
Traceable Author Statement
more info
 
involved_in rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in rRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rRNA processing TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of cytoplasmic exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of exosome (RNase complex) NAS
Non-traceable Author Statement
more info
PubMed 
part_of exosome (RNase complex) TAS
Traceable Author Statement
more info
PubMed 
located_in membrane HDA PubMed 
part_of nuclear exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of nuclear exosome (RNase complex) IDA
Inferred from Direct Assay
more info
PubMed 
part_of nuclear exosome (RNase complex) NAS
Non-traceable Author Statement
more info
PubMed 
NOT located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
exosome complex exonuclease RRP44
Names
DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
DIS3 mitotic control homolog
exosome component 11
mitotic control protein dis3 homolog
ribosomal RNA-processing protein 44

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128226.3NP_001121698.1  exosome complex exonuclease RRP44 isoform b

    See identical proteins and their annotated locations for NP_001121698.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon and contains an alternate exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AB023225, AL080158, AL138695, AL832266, U79246
    Consensus CDS
    CCDS45057.1
    UniProtKB/TrEMBL
    A8QI98
    Related
    ENSP00000367011.4, ENST00000377780.8
    Conserved Domains (3) summary
    COG0557
    Location:192900
    VacB; Exoribonuclease R [Transcription]
    pfam00773
    Location:437765
    RNB; RNB domain
    cl14812
    Location:9167
    PIN_SF; PIN (PilT N terminus) domain: Superfamily
  2. NM_001322348.2NP_001309277.1  exosome complex exonuclease RRP44 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL138695, AL391384
    UniProtKB/TrEMBL
    Q49AG4
    Conserved Domains (3) summary
    COG0557
    Location:99807
    VacB; Exoribonuclease R [Transcription]
    pfam00773
    Location:344672
    RNB; RNB domain
    cl14812
    Location:674
    PIN_SF; PIN (PilT N terminus) domain: Superfamily
  3. NM_001322349.2NP_001309278.1  exosome complex exonuclease RRP44 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL138695, AL391384
    Consensus CDS
    CCDS81772.1
    UniProtKB/TrEMBL
    G3V1J5, Q49AG4
    Related
    ENSP00000440058.1, ENST00000545453.5
    Conserved Domains (3) summary
    COG0557
    Location:60768
    VacB; Exoribonuclease R [Transcription]
    pfam00773
    Location:305633
    RNB; RNB domain
    cl14812
    Location:335
    PIN_SF; PIN (PilT N terminus) domain: Superfamily
  4. NM_014953.5NP_055768.3  exosome complex exonuclease RRP44 isoform a

    See identical proteins and their annotated locations for NP_055768.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AL080158, AL138695, AL832266, BC056143, U79246
    Consensus CDS
    CCDS9447.1
    UniProtKB/Swiss-Prot
    A6NI21, B2RBL2, Q5W0P7, Q5W0P8, Q658Z7, Q7Z481, Q8WWI2, Q9UG36, Q9Y2L1
    UniProtKB/TrEMBL
    A8QI98
    Related
    ENSP00000366997.4, ENST00000377767.9
    Conserved Domains (3) summary
    cd09862
    Location:9197
    PIN_Rrp44; PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
    COG0557
    Location:222930
    VacB; Exoribonuclease R [Transcription]
    pfam00773
    Location:467795
    RNB; RNB domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    72752169..72781900 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    71973643..72003383 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)