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DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease [ Homo sapiens (human) ]

Gene ID: 22894, updated on 9-Feb-2020

Summary

Official Symbol
DIS3provided by HGNC
Official Full Name
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonucleaseprovided by HGNC
Primary source
HGNC:HGNC:20604
See related
Ensembl:ENSG00000083520 MIM:607533
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RRP44; dis3p; EXOSC11; KIAA1008; 2810028N01Rik
Expression
Ubiquitous expression in testis (RPKM 10.1), lymph node (RPKM 7.2) and 25 other tissues See more
Orthologs

Genomic context

See DIS3 in Genome Data Viewer
Location:
13q21.33
Exon count:
22
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (72752169..72781900, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (73329540..73356344, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 80, pseudogene Neighboring gene mitotic spindle organizing protein 1 Neighboring gene BORA aurora kinase A activator Neighboring gene progesterone immunomodulatory binding factor 1 Neighboring gene RNA, U6 small nuclear 79, pseudogene Neighboring gene proteasome 26S subunit, non-ATPase, 10 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10484, MGC33035, DKFZp667L1817

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3'-5'-exoribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
3'-5'-exoribonuclease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
3'-5'-exoribonuclease activity TAS
Traceable Author Statement
more info
 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endonuclease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
CUT catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
RNA phosphodiester bond hydrolysis, exonucleolytic IEA
Inferred from Electronic Annotation
more info
 
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay TAS
Traceable Author Statement
more info
 
rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
rRNA processing TAS
Traceable Author Statement
more info
PubMed 
regulation of mRNA stability TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasmic exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
exosome (RNase complex) TAS
Traceable Author Statement
more info
PubMed 
membrane HDA PubMed 
nuclear exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear exosome (RNase complex) IDA
Inferred from Direct Assay
more info
PubMed 
NOT nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
exosome complex exonuclease RRP44
Names
DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
DIS3 mitotic control homolog
exosome component 11
mitotic control protein dis3 homolog
ribosomal RNA-processing protein 44

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128226.3NP_001121698.1  exosome complex exonuclease RRP44 isoform b

    See identical proteins and their annotated locations for NP_001121698.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon and contains an alternate exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AB023225, AL080158, AL138695, AL832266, U79246
    Consensus CDS
    CCDS45057.1
    UniProtKB/Swiss-Prot
    Q9Y2L1
    Related
    ENSP00000367011.4, ENST00000377780.8
    Conserved Domains (3) summary
    COG0557
    Location:192900
    VacB; Exoribonuclease R [Transcription]
    pfam00773
    Location:437765
    RNB; RNB domain
    cl14812
    Location:9167
    PIN_SF; PIN (PilT N terminus) domain: Superfamily
  2. NM_001322348.2NP_001309277.1  exosome complex exonuclease RRP44 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL138695, AL391384
    Conserved Domains (3) summary
    COG0557
    Location:99807
    VacB; Exoribonuclease R [Transcription]
    pfam00773
    Location:344672
    RNB; RNB domain
    cl14812
    Location:674
    PIN_SF; PIN (PilT N terminus) domain: Superfamily
  3. NM_001322349.2NP_001309278.1  exosome complex exonuclease RRP44 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL138695, AL391384
    Consensus CDS
    CCDS81772.1
    UniProtKB/TrEMBL
    G3V1J5
    Related
    ENSP00000440058.1, ENST00000545453.5
    Conserved Domains (3) summary
    COG0557
    Location:60768
    VacB; Exoribonuclease R [Transcription]
    pfam00773
    Location:305633
    RNB; RNB domain
    cl14812
    Location:335
    PIN_SF; PIN (PilT N terminus) domain: Superfamily
  4. NM_014953.5NP_055768.3  exosome complex exonuclease RRP44 isoform a

    See identical proteins and their annotated locations for NP_055768.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AL080158, AL138695, AL832266, BC056143, U79246
    Consensus CDS
    CCDS9447.1
    UniProtKB/Swiss-Prot
    Q9Y2L1
    Related
    ENSP00000366997.4, ENST00000377767.9
    Conserved Domains (3) summary
    cd09862
    Location:9197
    PIN_Rrp44; PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
    COG0557
    Location:222930
    VacB; Exoribonuclease R [Transcription]
    pfam00773
    Location:467795
    RNB; RNB domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    72752169..72781900 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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