U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tshz2 teashirt zinc finger family member 2 [ Mus musculus (house mouse) ]

Gene ID: 228911, updated on 24-Jan-2023

Summary

Official Symbol
Tshz2provided by MGI
Official Full Name
teashirt zinc finger family member 2provided by MGI
Primary source
MGI:MGI:2153084
See related
Ensembl:ENSMUSG00000047907 AllianceGenome:MGI:2153084
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tsh2; Mtsh2; Zfp218; Sdccag33l; mKIAA4248; teashirt2; B830045G17; 2900073F20Rik
Summary
Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within regulation of gene expression. Predicted to be active in nucleus. Is expressed in several structures, including forelimb; genitourinary system; hindgut; limb bud; and vibrissa. Orthologous to human TSHZ2 (teashirt zinc finger homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in genital fat pad adult (RPKM 8.3), bladder adult (RPKM 7.5) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Tshz2 in Genome Data Viewer
Location:
2 H3; 2 89.47 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (169474429..169914671)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (169632509..170072751)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1064 Neighboring gene predicted gene, 34294 Neighboring gene predicted gene, 34344 Neighboring gene predicted gene, 54131 Neighboring gene cDNA sequence AY702102 Neighboring gene RIKEN cDNA A630075F10 gene Neighboring gene zinc finger protein 217 Neighboring gene predicted gene, 34403

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transposon induced (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA4248

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
teashirt homolog 2
Names
SDCCAG33-like protein
serologically defined colon cancer antigen 33 like
teashirt 2
zinc finger protein 218

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363022.2NP_001349951.1  teashirt homolog 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AL731822, AL731826
    Consensus CDS
    CCDS50805.1
    UniProtKB/Swiss-Prot
    Q9JL71
    Conserved Domains (1) summary
    cd00086
    Location:838906
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  2. NM_001363023.2NP_001349952.1  teashirt homolog 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AL731822, AL731826
    Consensus CDS
    CCDS50805.1
    UniProtKB/Swiss-Prot
    Q9JL71
    Related
    ENSMUSP00000104787.3, ENSMUST00000109159.3
    Conserved Domains (1) summary
    cd00086
    Location:838906
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  3. NM_080455.4NP_536703.2  teashirt homolog 2 isoform a

    See identical proteins and their annotated locations for NP_536703.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AL731822, AL731826
    Consensus CDS
    CCDS50805.1
    UniProtKB/Swiss-Prot
    Q68FE9, Q9JL71
    Related
    ENSMUSP00000104785.2, ENSMUST00000109157.2
    Conserved Domains (1) summary
    cd00086
    Location:838906
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  4. NM_177659.2NP_808327.1  teashirt homolog 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction in the 3' end compared to variant 1. The resulting isoform (b) is shorter at the C-terminus compared to isoform a.
    Source sequence(s)
    AL731822, AL731826
    Conserved Domains (2) summary
    cd00086
    Location:838906
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00020
    Location:218240
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    169474429..169914671
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161701.1XP_036017594.1  teashirt homolog 2 isoform X4

    Conserved Domains (2) summary
    cd00086
    Location:838906
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00020
    Location:218240
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_006499424.5XP_006499487.2  teashirt homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_006499487.2

    Conserved Domains (2) summary
    cd00086
    Location:858926
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00020
    Location:238260
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. XM_006499426.5XP_006499489.2  teashirt homolog 2 isoform X3

    See identical proteins and their annotated locations for XP_006499489.2

    Conserved Domains (2) summary
    cd00086
    Location:858926
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00020
    Location:238260
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. XM_006499423.5XP_006499486.2  teashirt homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_006499486.2

    Conserved Domains (2) summary
    cd00086
    Location:858926
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00020
    Location:238260
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. XM_006499425.5XP_006499488.2  teashirt homolog 2 isoform X2

    See identical proteins and their annotated locations for XP_006499488.2

    Conserved Domains (2) summary
    cd00086
    Location:858926
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00020
    Location:238260
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. XM_030250745.2XP_030106605.1  teashirt homolog 2 isoform X1

    Conserved Domains (2) summary
    cd00086
    Location:858926
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00020
    Location:238260
    ZF_C2H2; C2H2 Zn finger [structural motif]