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UBOX5 U-box domain containing 5 [ Homo sapiens (human) ]

Gene ID: 22888, updated on 12-Oct-2019

Summary

Official Symbol
UBOX5provided by HGNC
Official Full Name
U-box domain containing 5provided by HGNC
Primary source
HGNC:HGNC:17777
See related
Ensembl:ENSG00000185019
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UIP5; RNF37; hUIP5; UBCE7IP5
Summary
This gene encodes a U-box domain containing protein. The encoded protein interacts with E2 enzymes and may play a role in the ubiquitination pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Expression
Ubiquitous expression in testis (RPKM 3.8), ovary (RPKM 3.5) and 25 other tissues See more
Orthologs

Genomic context

See UBOX5 in Genome Data Viewer
Location:
20p13
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (3107573..3159865, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (3088219..3140556, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene arginine vasopressin Neighboring gene RNA, 7SL, cytoplasmic 555, pseudogene Neighboring gene UBOX5 antisense RNA 1 Neighboring gene FAST kinase domains 5 Neighboring gene leucine zipper tumor suppressor family member 3 Neighboring gene uncharacterized LOC107985414

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
    Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
  • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
    Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0860

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-ubiquitin ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-ubiquitin ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein polyubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
focal adhesion IDA
Inferred from Direct Assay
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
RING finger protein 37
Names
RING-type E3 ubiquitin transferase RNF37
U-box domain-containing protein 5
ubcM4-interacting protein 5
ubiquitin conjugating enzyme 7 interacting protein 5
NP_001254513.1
NP_055763.1
NP_955447.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267584.2NP_001254513.1  RING finger protein 37 isoform c

    See identical proteins and their annotated locations for NP_001254513.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, compared to variant 1, which results in a translational frameshift, compared to variant 1. The resulting isoform (c) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL121891, BC064544, BM992259, DA101925
    Conserved Domains (1) summary
    pfam04564
    Location:259337
    U-box; U-box domain
  2. NM_014948.4NP_055763.1  RING finger protein 37 isoform a

    See identical proteins and their annotated locations for NP_055763.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AB020667, AL121891, BM992259
    Consensus CDS
    CCDS13046.1
    UniProtKB/Swiss-Prot
    O94941
    Related
    ENSP00000217173.2, ENST00000217173.7
    Conserved Domains (2) summary
    cd16537
    Location:482528
    RING-HC_RNF37; RING finger, HC subclass, found in RING finger protein 37 (RNF37)
    cd16660
    Location:260312
    RING-Ubox_RNF37; U-box domain, a modified RING finger, found in RING finger protein 37 (RNF37)
  3. NM_199415.3NP_955447.1  RING finger protein 37 isoform b

    See identical proteins and their annotated locations for NP_955447.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AL121891, BC046122, BM992259
    Consensus CDS
    CCDS13047.1
    UniProtKB/Swiss-Prot
    O94941
    Related
    ENSP00000311726.3, ENST00000348031.6
    Conserved Domains (2) summary
    pfam04564
    Location:259337
    U-box; U-box domain
    pfam14634
    Location:432475
    zf-RING_5; zinc-RING finger domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    3107573..3159865 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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