U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ralgapb Ral GTPase activating protein, beta subunit (non-catalytic) [ Mus musculus (house mouse) ]

Gene ID: 228850, updated on 4-Dec-2022

Summary

Official Symbol
Ralgapbprovided by MGI
Official Full Name
Ral GTPase activating protein, beta subunit (non-catalytic)provided by MGI
Primary source
MGI:MGI:2444531
See related
Ensembl:ENSMUSG00000027652 AllianceGenome:MGI:2444531
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p170; B230339M05Rik
Summary
Enables GTPase activator activity. Acts upstream of or within several processes, including Ral protein signal transduction; activation of GTPase activity; and regulation of exocyst localization. Predicted to be located in cytosol. Is expressed in central nervous system and retina. Orthologous to human RALGAPB (Ral GTPase activating protein non-catalytic subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 10.3), whole brain E14.5 (RPKM 9.7) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Ralgapb in Genome Data Viewer
Location:
2; 2 H1
Exon count:
33
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (158251722..158341173)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (158409830..158499253)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA host gene 11 Neighboring gene predicted gene, 25187 Neighboring gene predicted gene, 25129 Neighboring gene predicted gene 14200 Neighboring gene predicted gene, 54127 Neighboring gene adipogenin Neighboring gene Rho GTPase activating protein 40

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1219, 9330195P16

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activator activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ral GTPase-activating protein subunit beta
Names
ral GTPase-activating protein beta subunit

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291137.1NP_001278066.1  ral GTPase-activating protein subunit beta isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AI836674, AL663091, AL844513, CJ119771
    Consensus CDS
    CCDS71178.1
    UniProtKB/TrEMBL
    E9Q0J2
    Related
    ENSMUSP00000105111.3, ENSMUST00000109485.9
    Conserved Domains (1) summary
    pfam10428
    Location:354427
    SOG2; RAM signalling pathway protein
  2. NM_001291138.1NP_001278067.1  ral GTPase-activating protein subunit beta isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AI836674, AL663091, AL844513, CJ119771
    Consensus CDS
    CCDS71179.1
    UniProtKB/TrEMBL
    A2ACC6
    Related
    ENSMUSP00000105112.3, ENSMUST00000109486.9
    Conserved Domains (1) summary
    pfam10428
    Location:354427
    SOG2; RAM signalling pathway protein
  3. NM_001363006.1NP_001349935.1  ral GTPase-activating protein subunit beta isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AL663091, AL844513
  4. NM_001369183.1NP_001356112.1  ral GTPase-activating protein subunit beta isoform d

    Status: VALIDATED

    Source sequence(s)
    AL663091, AL844513
    Related
    ENSMUSP00000116481.2, ENSMUST00000141497.2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    158251722..158341173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499359.5XP_006499422.1  ral GTPase-activating protein subunit beta isoform X2

    Conserved Domains (1) summary
    pfam10428
    Location:354427
    SOG2; RAM signalling pathway protein
  2. XM_006499361.5XP_006499424.1  ral GTPase-activating protein subunit beta isoform X3

    Conserved Domains (1) summary
    pfam10428
    Location:354427
    SOG2; RAM signalling pathway protein
  3. XM_006499357.5XP_006499420.1  ral GTPase-activating protein subunit beta isoform X1

    See identical proteins and their annotated locations for XP_006499420.1

    Conserved Domains (1) summary
    pfam10428
    Location:354427
    SOG2; RAM signalling pathway protein
  4. XM_006499363.5XP_006499426.1  ral GTPase-activating protein subunit beta isoform X5

    Conserved Domains (1) summary
    pfam10428
    Location:354427
    SOG2; RAM signalling pathway protein
  5. XM_036161598.1XP_036017491.1  ral GTPase-activating protein subunit beta isoform X7

  6. XM_006499362.5XP_006499425.1  ral GTPase-activating protein subunit beta isoform X4

    Conserved Domains (1) summary
    pfam10428
    Location:354427
    SOG2; RAM signalling pathway protein
  7. XM_011239490.4XP_011237792.1  ral GTPase-activating protein subunit beta isoform X6

    UniProtKB/TrEMBL
    F8WHN4
    Related
    ENSMUSP00000048430.6, ENSMUST00000046274.12
    Conserved Domains (1) summary
    pfam10428
    Location:354427
    SOG2; RAM signalling pathway protein
  8. XM_011239491.4XP_011237793.1  ral GTPase-activating protein subunit beta isoform X9

    Conserved Domains (1) summary
    pfam10428
    Location:354427
    SOG2; RAM signalling pathway protein
  9. XM_017317885.3XP_017173374.1  ral GTPase-activating protein subunit beta isoform X8

  10. XM_006499358.2XP_006499421.1  ral GTPase-activating protein subunit beta isoform X1

    See identical proteins and their annotated locations for XP_006499421.1

    Conserved Domains (1) summary
    pfam10428
    Location:354427
    SOG2; RAM signalling pathway protein

RNA

  1. XR_004940148.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177227.2: Suppressed sequence

    Description
    NM_177227.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_177658.3: Suppressed sequence

    Description
    NM_177658.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.