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WDR37 WD repeat domain 37 [ Homo sapiens (human) ]

Gene ID: 22884, updated on 22-Sep-2022

Summary

Official Symbol
WDR37provided by HGNC
Official Full Name
WD repeat domain 37provided by HGNC
Primary source
HGNC:HGNC:31406
See related
Ensembl:ENSG00000047056 MIM:618586; AllianceGenome:HGNC:31406
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NOCGUS
Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 11.4), spleen (RPKM 8.6) and 25 other tissues See more
Orthologs
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Genomic context

See WDR37 in Genome Data Viewer
Location:
10p15.3
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (1056385..1132372)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (1053000..1128899)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (1102325..1178312)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene GTP binding protein 4 Neighboring gene IDI2 antisense RNA 1 Neighboring gene isopentenyl-diphosphate delta isomerase 2 Neighboring gene isopentenyl-diphosphate delta isomerase 1 Neighboring gene uncharacterized LOC105376344 Neighboring gene long intergenic non-protein coding RNA 200

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Neurooculocardiogenitourinary syndrome
MedGen: C5231443 OMIM: 618652 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
EBI GWAS Catalog
New loci associated with kidney function and chronic kidney disease.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40354, KIAA0982

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in corpus callosum development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
WD repeat-containing protein 37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014023.4NP_054742.2  WD repeat-containing protein 37

    See identical proteins and their annotated locations for NP_054742.2

    Status: REVIEWED

    Source sequence(s)
    AB023199, AC022536, AL136827, AL607085
    Consensus CDS
    CCDS7057.1
    UniProtKB/Swiss-Prot
    Q9NTJ6, Q9Y2I8
    Related
    ENSP00000263150.4, ENST00000263150.9
    Conserved Domains (3) summary
    COG2319
    Location:124486
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:148484
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:159197
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    1056385..1132372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    1053000..1128899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)