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Tgif2 TGFB-induced factor homeobox 2 [ Mus musculus (house mouse) ]

Gene ID: 228839, updated on 30-Apr-2024

Summary

Official Symbol
Tgif2provided by MGI
Official Full Name
TGFB-induced factor homeobox 2provided by MGI
Primary source
MGI:MGI:1915299
See related
Ensembl:ENSMUSG00000062175 AllianceGenome:MGI:1915299
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4921501K24; 5730599O09Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including nodal signaling pathway; positive regulation of neuron differentiation; and regulation of gastrulation. Predicted to be located in centrosome and nucleoplasm. Is expressed in several structures, including alimentary system; brain; forelimb phalanx; genitourinary system; and sensory organ. Orthologous to several human genes including TGIF2-RAB5IF (TGIF2-RAB5IF readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 11.1), limb E14.5 (RPKM 10.5) and 25 other tissues See more
Orthologs
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Genomic context

See Tgif2 in Genome Data Viewer
Location:
2 H1; 2 77.86 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (156681737..156697490)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (156839817..156855570)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06181 Neighboring gene myosin, light polypeptide 9, regulatory Neighboring gene STARR-seq mESC enhancer starr_06182 Neighboring gene ribosomal protein L9 pseudogene Neighboring gene VISTA enhancer mm1377 Neighboring gene predicted gene 14230 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:156665530-156665639 Neighboring gene RIKEN cDNA 5430405H02 gene Neighboring gene STARR-positive B cell enhancer ABC_E1606 Neighboring gene RAB5 interacting factor Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:156712828-156713029 Neighboring gene Src-like-adaptor 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
homeobox protein TGIF2
Names
5'-TG-3'-interacting factor 2
TALE family homeobox
TGF-beta-induced transcription factor 2
TGFB-induced factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291124.1NP_001278053.1  homeobox protein TGIF2 isoform b

    See identical proteins and their annotated locations for NP_001278053.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AK029490, AL935150, BQ030806, CF731285
    Consensus CDS
    CCDS71173.1
    UniProtKB/TrEMBL
    Q3TZS1
    Related
    ENSMUSP00000073074.4, ENSMUST00000073352.10
    Conserved Domains (1) summary
    pfam05920
    Location:3675
    Homeobox_KN; Homeobox KN domain
  2. NM_173396.3NP_775572.1  homeobox protein TGIF2 isoform a

    See identical proteins and their annotated locations for NP_775572.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK029490, AL935150, BQ030806
    Consensus CDS
    CCDS16969.1
    UniProtKB/Swiss-Prot
    Q8C0Y1
    UniProtKB/TrEMBL
    A2AVY9
    Related
    ENSMUSP00000096745.5, ENSMUST00000081335.13
    Conserved Domains (1) summary
    pfam05920
    Location:3675
    Homeobox_KN; Homeobox KN domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    156681737..156697490
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499353.3XP_006499416.1  homeobox protein TGIF2 isoform X1

    See identical proteins and their annotated locations for XP_006499416.1

    UniProtKB/Swiss-Prot
    Q8C0Y1
    UniProtKB/TrEMBL
    A2AVY9
    Conserved Domains (1) summary
    pfam05920
    Location:3675
    Homeobox_KN; Homeobox KN domain
  2. XM_006499354.5XP_006499417.1  homeobox protein TGIF2 isoform X1

    See identical proteins and their annotated locations for XP_006499417.1

    UniProtKB/Swiss-Prot
    Q8C0Y1
    UniProtKB/TrEMBL
    A2AVY9
    Conserved Domains (1) summary
    pfam05920
    Location:3675
    Homeobox_KN; Homeobox KN domain
  3. XM_036161592.1XP_036017485.1  homeobox protein TGIF2 isoform X2

    UniProtKB/TrEMBL
    Q3TZS1
    Conserved Domains (1) summary
    pfam05920
    Location:3675
    Homeobox_KN; Homeobox KN domain
  4. XM_006499351.5XP_006499414.1  homeobox protein TGIF2 isoform X1

    See identical proteins and their annotated locations for XP_006499414.1

    UniProtKB/Swiss-Prot
    Q8C0Y1
    UniProtKB/TrEMBL
    A2AVY9
    Conserved Domains (1) summary
    pfam05920
    Location:3675
    Homeobox_KN; Homeobox KN domain
  5. XM_030250654.2XP_030106514.1  homeobox protein TGIF2 isoform X2

    UniProtKB/TrEMBL
    Q3TZS1
    Conserved Domains (1) summary
    pfam05920
    Location:3675
    Homeobox_KN; Homeobox KN domain
  6. XM_036161591.1XP_036017484.1  homeobox protein TGIF2 isoform X2

    UniProtKB/TrEMBL
    Q3TZS1
    Conserved Domains (1) summary
    pfam05920
    Location:3675
    Homeobox_KN; Homeobox KN domain
  7. XM_006499352.5XP_006499415.1  homeobox protein TGIF2 isoform X1

    See identical proteins and their annotated locations for XP_006499415.1

    UniProtKB/Swiss-Prot
    Q8C0Y1
    UniProtKB/TrEMBL
    A2AVY9
    Conserved Domains (1) summary
    pfam05920
    Location:3675
    Homeobox_KN; Homeobox KN domain