U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ANKRD6 ankyrin repeat domain 6 [ Homo sapiens (human) ]

Gene ID: 22881, updated on 5-Aug-2022

Summary

Official Symbol
ANKRD6provided by HGNC
Official Full Name
ankyrin repeat domain 6provided by HGNC
Primary source
HGNC:HGNC:17280
See related
Ensembl:ENSG00000135299 MIM:610583; AllianceGenome:HGNC:17280
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be involved in negative regulation of canonical Wnt signaling pathway and positive regulation of JNK cascade. Predicted to act upstream of or within positive regulation of Wnt signaling pathway, planar cell polarity pathway. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 8.1), ovary (RPKM 5.5) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ANKRD6 in Genome Data Viewer
Location:
6q15
Exon count:
20
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (89433152..89633834)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (90642513..90843208)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (90142871..90343553)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 13381 Neighboring gene Ras related GTP binding D Neighboring gene uncharacterized LOC124901360 Neighboring gene NACA pseudogene 7 Neighboring gene RNA, 7SL, cytoplasmic 11, pseudogene Neighboring gene uncharacterized LOC105377889 Neighboring gene uncharacterized LOC124901359 Neighboring gene MDN1 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 852 Neighboring gene LYR motif containing 2 Neighboring gene midasin AAA ATPase 1 Neighboring gene DnaJ heat shock protein family (Hsp40) member C19 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels.
EBI GWAS Catalog
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ankyrin repeat domain 6 (ANKRD6) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12637, FLJ34916

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ankyrin repeat domain-containing protein 6
Names
diego homolog
diversin
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242809.2NP_001229738.1  ankyrin repeat domain-containing protein 6 isoform a

    See identical proteins and their annotated locations for NP_001229738.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same longest isoform (a).
    Source sequence(s)
    AK295731, AL096678, AL138717, DN999929
    Consensus CDS
    CCDS56441.1
    UniProtKB/Swiss-Prot
    Q9UFQ9, Q9Y2G4
    UniProtKB/TrEMBL
    B7Z3D2
    Related
    ENSP00000345767.4, ENST00000339746.9
    Conserved Domains (3) summary
    PHA03095
    Location:29265
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:141171
    ANK; ANK repeat [structural motif]
    NF033885
    Location:632724
    conj_TraP_IncI1; conjugal transfer protein TraP
  2. NM_001242811.1NP_001229740.1  ankyrin repeat domain-containing protein 6 isoform a

    See identical proteins and their annotated locations for NP_001229740.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR exon, and encodes the same isoform a, compared to variant 1.
    Source sequence(s)
    AK295731, AL096678, BC042173, DC317010
    Consensus CDS
    CCDS56441.1
    UniProtKB/Swiss-Prot
    Q9UFQ9, Q9Y2G4
    UniProtKB/TrEMBL
    B7Z3D2
    Related
    ENSP00000430985.1, ENST00000522441.5
    Conserved Domains (3) summary
    PHA03095
    Location:29265
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:141171
    ANK; ANK repeat [structural motif]
    NF033885
    Location:632724
    conj_TraP_IncI1; conjugal transfer protein TraP
  3. NM_001242813.1NP_001229742.1  ankyrin repeat domain-containing protein 6 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (c) lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AB023174, AK295731, AL096678, DN999929
    Consensus CDS
    CCDS56442.1
    UniProtKB/Swiss-Prot
    Q9Y2G4
    UniProtKB/TrEMBL
    B7Z3D2
    Related
    ENSP00000358416.5, ENST00000369408.9
    Conserved Domains (3) summary
    cd00204
    Location:102227
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:141171
    ANK; ANK repeat [structural motif]
    cl26072
    Location:190270
    Ank_5; Ankyrin repeats (many copies)
  4. NM_001242814.1NP_001229743.1  ankyrin repeat domain-containing protein 6 isoform d

    See identical proteins and their annotated locations for NP_001229743.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two in-frame exons in the coding region, compared to variant 1. The resulting isoform (d) lacks two internal segments, compared to isoform a.
    Source sequence(s)
    AB023174, AK096867, AL096678
    Consensus CDS
    CCDS56443.1
    UniProtKB/Swiss-Prot
    Q9Y2G4
    Related
    ENSP00000429782.1, ENST00000520793.5
    Conserved Domains (5) summary
    cd00204
    Location:37161
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00023
    Location:174205
    Ank; Ankyrin repeat
    pfam12796
    Location:112204
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:1462
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:108138
    ANK; ANK repeat [structural motif]
  5. NM_014942.4NP_055757.3  ankyrin repeat domain-containing protein 6 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate splice site in the coding region, and the open reading frame is retained, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AK295731, AL096678, BC042173, DN999929
    Consensus CDS
    CCDS47460.1
    UniProtKB/Swiss-Prot
    Q9Y2G4
    UniProtKB/TrEMBL
    B7Z3D2
    Related
    ENSP00000396771.2, ENST00000447838.6
    Conserved Domains (3) summary
    cd00204
    Location:102227
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:141171
    ANK; ANK repeat [structural motif]
    cl26073
    Location:127382
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    89433152..89633834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418408.1XP_047274364.1  ankyrin repeat domain-containing protein 6 isoform X35

  2. XM_047418410.1XP_047274366.1  ankyrin repeat domain-containing protein 6 isoform X35

  3. XM_047418412.1XP_047274368.1  ankyrin repeat domain-containing protein 6 isoform X35

  4. XM_047418413.1XP_047274369.1  ankyrin repeat domain-containing protein 6 isoform X35

  5. XM_047418415.1XP_047274371.1  ankyrin repeat domain-containing protein 6 isoform X35

  6. XM_005248681.3XP_005248738.1  ankyrin repeat domain-containing protein 6 isoform X3

    See identical proteins and their annotated locations for XP_005248738.1

    UniProtKB/Swiss-Prot
    Q9UFQ9, Q9Y2G4
    Conserved Domains (3) summary
    PHA03095
    Location:29265
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:141171
    ANK; ANK repeat [structural motif]
    NF033885
    Location:632724
    conj_TraP_IncI1; conjugal transfer protein TraP
  7. XM_047418398.1XP_047274354.1  ankyrin repeat domain-containing protein 6 isoform X5

  8. XM_047418401.1XP_047274357.1  ankyrin repeat domain-containing protein 6 isoform X12

  9. XM_047418405.1XP_047274361.1  ankyrin repeat domain-containing protein 6 isoform X22

  10. XM_017010513.2XP_016866002.1  ankyrin repeat domain-containing protein 6 isoform X34

    Conserved Domains (3) summary
    cd00204
    Location:14128
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:4172
    ANK; ANK repeat [structural motif]
    cl26073
    Location:42222
    Ank_2; Ankyrin repeats (3 copies)
  11. XM_047418409.1XP_047274365.1  ankyrin repeat domain-containing protein 6 isoform X36

  12. XM_047418402.1XP_047274358.1  ankyrin repeat domain-containing protein 6 isoform X14

  13. XM_024446357.2XP_024302125.1  ankyrin repeat domain-containing protein 6 isoform X5

    Conserved Domains (3) summary
    cd00204
    Location:102227
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:141171
    ANK; ANK repeat [structural motif]
    cl26073
    Location:127382
    Ank_2; Ankyrin repeats (3 copies)
  14. XM_024446359.2XP_024302127.1  ankyrin repeat domain-containing protein 6 isoform X15

    Conserved Domains (3) summary
    cd00204
    Location:102227
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:141171
    ANK; ANK repeat [structural motif]
    cl26072
    Location:190270
    Ank_5; Ankyrin repeats (many copies)
  15. XM_024446361.2XP_024302129.1  ankyrin repeat domain-containing protein 6 isoform X17

    Conserved Domains (3) summary
    cd00204
    Location:102227
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:141171
    ANK; ANK repeat [structural motif]
    cl26072
    Location:190270
    Ank_5; Ankyrin repeats (many copies)
  16. XM_047418399.1XP_047274355.1  ankyrin repeat domain-containing protein 6 isoform X10

  17. XM_047418400.1XP_047274356.1  ankyrin repeat domain-containing protein 6 isoform X11

  18. XM_024446358.2XP_024302126.1  ankyrin repeat domain-containing protein 6 isoform X12

    Conserved Domains (2) summary
    cd00204
    Location:37161
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:4172
    ANK; ANK repeat [structural motif]
  19. XM_024446360.2XP_024302128.1  ankyrin repeat domain-containing protein 6 isoform X16

    Conserved Domains (2) summary
    cd00204
    Location:37161
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:4172
    ANK; ANK repeat [structural motif]
  20. XM_024446363.2XP_024302131.1  ankyrin repeat domain-containing protein 6 isoform X25

    Conserved Domains (2) summary
    cd00204
    Location:37161
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:4172
    ANK; ANK repeat [structural motif]
  21. XM_024446362.2XP_024302130.1  ankyrin repeat domain-containing protein 6 isoform X22

    Conserved Domains (3) summary
    cd00204
    Location:37161
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:4172
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:141193
    Ank_4; Ankyrin repeats (many copies)
  22. XM_024446364.2XP_024302132.1  ankyrin repeat domain-containing protein 6 isoform X26

    Conserved Domains (3) summary
    cd00204
    Location:37161
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:4172
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:141193
    Ank_4; Ankyrin repeats (many copies)
  23. XM_024446366.2XP_024302134.1  ankyrin repeat domain-containing protein 6 isoform X31

    Conserved Domains (3) summary
    cd00204
    Location:37161
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:4172
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:141193
    Ank_4; Ankyrin repeats (many copies)
  24. XM_047418407.1XP_047274363.1  ankyrin repeat domain-containing protein 6 isoform X29

  25. XM_024446368.2XP_024302136.1  ankyrin repeat domain-containing protein 6 isoform X34

    Conserved Domains (3) summary
    cd00204
    Location:14128
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:4172
    ANK; ANK repeat [structural motif]
    cl26073
    Location:42222
    Ank_2; Ankyrin repeats (3 copies)
  26. XM_047418404.1XP_047274360.1  ankyrin repeat domain-containing protein 6 isoform X21

  27. XM_024446365.2XP_024302133.1  ankyrin repeat domain-containing protein 6 isoform X27

    Conserved Domains (3) summary
    cd00204
    Location:37161
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:4172
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:141193
    Ank_4; Ankyrin repeats (many copies)
  28. XM_017010496.3XP_016865985.1  ankyrin repeat domain-containing protein 6 isoform X13

    Conserved Domains (4) summary
    cd00204
    Location:69194
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:112204
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:1462
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:108138
    ANK; ANK repeat [structural motif]
  29. XM_017010502.3XP_016865991.1  ankyrin repeat domain-containing protein 6 isoform X23

  30. XM_017010508.2XP_016865997.1  ankyrin repeat domain-containing protein 6 isoform X30

  31. XM_017010511.3XP_016866000.1  ankyrin repeat domain-containing protein 6 isoform X32

  32. XM_047418411.1XP_047274367.1  ankyrin repeat domain-containing protein 6 isoform X37

  33. XM_017010503.2XP_016865992.1  ankyrin repeat domain-containing protein 6 isoform X24

  34. XM_005248679.4XP_005248736.1  ankyrin repeat domain-containing protein 6 isoform X1

    Conserved Domains (3) summary
    cd00204
    Location:127252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:170262
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:166196
    ANK; ANK repeat [structural motif]
  35. XM_047418397.1XP_047274353.1  ankyrin repeat domain-containing protein 6 isoform X2

  36. XM_017010493.2XP_016865982.1  ankyrin repeat domain-containing protein 6 isoform X8

  37. XM_005248682.4XP_005248739.1  ankyrin repeat domain-containing protein 6 isoform X4

    Conserved Domains (3) summary
    cd00204
    Location:127252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:170262
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:166196
    ANK; ANK repeat [structural motif]
  38. XM_011535596.3XP_011533898.1  ankyrin repeat domain-containing protein 6 isoform X6

    Conserved Domains (4) summary
    cd00204
    Location:127251
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:137229
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:102153
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:132163
    ANK; ANK repeat [structural motif]
  39. XM_017010494.2XP_016865983.1  ankyrin repeat domain-containing protein 6 isoform X9

  40. XM_017010499.2XP_016865988.1  ankyrin repeat domain-containing protein 6 isoform X19

  41. XM_005248683.4XP_005248740.1  ankyrin repeat domain-containing protein 6 isoform X18

    Conserved Domains (3) summary
    cd00204
    Location:101218
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:104196
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:101130
    ANK; ANK repeat [structural motif]
  42. XM_017010500.2XP_016865989.1  ankyrin repeat domain-containing protein 6 isoform X20

  43. XM_005248684.4XP_005248741.1  ankyrin repeat domain-containing protein 6 isoform X33

    Conserved Domains (3) summary
    cd00204
    Location:101173
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam13637
    Location:102153
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:98130
    ANK; ANK repeat [structural motif]
  44. XM_011535597.3XP_011533899.1  ankyrin repeat domain-containing protein 6 isoform X7

    Conserved Domains (4) summary
    cd00204
    Location:127251
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:137229
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:102153
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:133163
    ANK; ANK repeat [structural motif]
  45. XM_047418406.1XP_047274362.1  ankyrin repeat domain-containing protein 6 isoform X28

  46. XM_047418414.1XP_047274370.1  ankyrin repeat domain-containing protein 6 isoform X38

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    90642513..90843208
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)