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MORC2 MORC family CW-type zinc finger 2 [ Homo sapiens (human) ]

Gene ID: 22880, updated on 26-Oct-2020

Summary

Official Symbol
MORC2provided by HGNC
Official Full Name
MORC family CW-type zinc finger 2provided by HGNC
Primary source
HGNC:HGNC:23573
See related
Ensembl:ENSG00000133422 MIM:616661
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZCW3; CMT2Z; ZCWCC1
Summary
This gene encodes a member of the Microrchidia (MORC) protein superfamily. The encoded protein is known to regulate the condensation of heterochromatin in response to DNA damage and play a role in repressing transcription. The protein has been found to regulate the activity of ATP citrate lyase via specific interaction with this enzyme in the cytosol of lipogenic breast cancer cells. The protein also plays a role in lipogenesis and adipocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
Expression
Broad expression in testis (RPKM 20.8), ovary (RPKM 5.3) and 24 other tissues See more
Orthologs

Genomic context

See MORC2 in Genome Data Viewer
Location:
22q12.2
Exon count:
27
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (30925130..30968774, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (31322598..31364483, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein 2 Neighboring gene origin of replication in OSBP2 Neighboring gene uncharacterized LOC107985544 Neighboring gene eukaryotic translation initiation factor 4H pseudogene 2 Neighboring gene MORC2 antisense RNA 1 Neighboring gene taurine up-regulated 1 Neighboring gene RNA, 7SL, cytoplasmic 633, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear matrix IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ATPase MORC2
Names
zinc finger CW-type coiled-coil domain protein 1
NP_001290185.1
NP_001290186.1
NP_055756.1
XP_011528306.1
XP_016884156.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046752.1 RefSeqGene

    Range
    4724..48368
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001303256.3NP_001290185.1  ATPase MORC2 isoform 1

    See identical proteins and their annotated locations for NP_001290185.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC004542, BC019257, BM683680, CD653611, DR000665
    Consensus CDS
    CCDS77668.1
    UniProtKB/Swiss-Prot
    Q9Y6X9
    Related
    ENSP00000380763.2, ENST00000397641.8
    Conserved Domains (2) summary
    pfam07496
    Location:495542
    zf-CW; CW-type Zinc Finger
    pfam13589
    Location:29169
    HATPase_c_3; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
  2. NM_001303257.2NP_001290186.1  ATPase MORC2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate, in-frame splice junction in the 3' coding region, compared to variant 1. This difference results in a shorter isoform (2) compared to variant 1.
    Source sequence(s)
    AC004542, BC019257, BM683680, BU733868, CD653611, DR000665
    UniProtKB/Swiss-Prot
    Q9Y6X9
    Conserved Domains (2) summary
    pfam07496
    Location:495542
    zf-CW; CW-type Zinc Finger
    pfam13589
    Location:29169
    HATPase_c_3; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
  3. NM_014941.3NP_055756.1  ATPase MORC2 isoform 3

    See identical proteins and their annotated locations for NP_055756.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an additional exon which results in the use of an in-frame downstream start codon, compared to variant 1. This difference results in an isoform (3) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AB020659, AC004542, BC019257, BM683680, CD653611
    Consensus CDS
    CCDS33636.1
    UniProtKB/Swiss-Prot
    Q9Y6X9
    Related
    ENSP00000215862.4, ENST00000215862.8
    Conserved Domains (4) summary
    pfam07496
    Location:433480
    zf-CW; CW-type Zinc Finger
    cl00075
    Location:1107
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
    cl26464
    Location:558673
    Atrophin-1; Atrophin-1 family
    cl26511
    Location:223302
    Neuromodulin_N; Gap junction protein N-terminal region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    30925130..30968774 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028667.2XP_016884156.1  ATPase MORC2 isoform X2

    Conserved Domains (4) summary
    PHA03247
    Location:625740
    PHA03247; large tegument protein UL36; Provisional
    cd16931
    Location:18140
    HATPase_MORC-like; Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains
    pfam07496
    Location:500547
    zf-CW; CW-type Zinc Finger
    pfam17942
    Location:244456
    Morc6_S5; Morc6 ribosomal protein S5 domain 2-like
  2. XM_011530004.2XP_011528306.1  ATPase MORC2 isoform X1

    Related
    ENST00000675601.1
    Conserved Domains (4) summary
    PHA03247
    Location:625740
    PHA03247; large tegument protein UL36; Provisional
    cd16931
    Location:18140
    HATPase_MORC-like; Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains
    pfam07496
    Location:500547
    zf-CW; CW-type Zinc Finger
    pfam17942
    Location:244456
    Morc6_S5; Morc6 ribosomal protein S5 domain 2-like
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