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Asxl1 additional sex combs like 1 [ Mus musculus (house mouse) ]

Gene ID: 228790, updated on 3-Jun-2018
Official Symbol
Asxl1provided by MGI
Official Full Name
additional sex combs like 1provided by MGI
Primary source
MGI:MGI:2684063
See related
Ensembl:ENSMUSG00000042548 Vega:OTTMUSG00000019852
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression
Ubiquitous expression in CNS E11.5 (RPKM 11.0), testis adult (RPKM 10.6) and 28 other tissues See more
Orthologs
See Asxl1 in Genome Data Viewer
Location:
2; 2 H1
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (153346139..153404007)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (153171875..153229743)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene kinesin family member 3B Neighboring gene RIKEN cDNA 2500004C02 gene Neighboring gene ATP synthase subunit d, mitochondrial-like Neighboring gene nucleolar protein 4-like Neighboring gene RIKEN cDNA 4930404H24 gene

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0978, DKFZp434N0535

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
peroxisome proliferator activated receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peroxisome proliferator activated receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
retinoic acid receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
bone development IMP
Inferred from Mutant Phenotype
more info
PubMed 
bone marrow development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromatin organization IEA
Inferred from Electronic Annotation
more info
 
heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
hematopoietic or lymphoid organ development IMP
Inferred from Mutant Phenotype
more info
PubMed 
hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
homeostasis of number of cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
lung saccule development IMP
Inferred from Mutant Phenotype
more info
PubMed 
monoubiquitinated histone H2A deubiquitination ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of peroxisome proliferator activated receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of retinoic acid receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to retinoic acid IDA
Inferred from Direct Assay
more info
PubMed 
thymus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
PR-DUB complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
PR-DUB complex ISO
Inferred from Sequence Orthology
more info
 
COLOCALIZES_WITH nuclear chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
COLOCALIZES_WITH nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
putative Polycomb group protein ASXL1
Names
additional sex combs-like protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039939.2NP_001035028.1  putative Polycomb group protein ASXL1

    See identical proteins and their annotated locations for NP_001035028.1

    Status: VALIDATED

    Source sequence(s)
    AK122413, AK141208, AL807380, BC076565
    Consensus CDS
    CCDS38285.1
    UniProtKB/Swiss-Prot
    P59598
    UniProtKB/TrEMBL
    Q24JP2
    Related
    ENSMUSP00000105413.1, OTTMUSP00000018159, ENSMUST00000109790.1
    Conserved Domains (3) summary
    pfam05066
    Location:1183
    HARE-HTH; HB1, ASXL, restriction endonuclease HTH domain
    pfam13919
    Location:236359
    ASXH; Asx homology domain
    pfam13922
    Location:14791512
    PHD_3; PHD domain of transcriptional enhancer, Asx

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

    Range
    153346139..153404007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499330.2XP_006499393.1  putative Polycomb group protein ASXL1 isoform X1

    Conserved Domains (2) summary
    pfam13919
    Location:156279
    ASXH; Asx homology domain
    pfam13922
    Location:13991432
    PHD_3; PHD domain of transcriptional enhancer, Asx

RNA

  1. XR_374455.3 RNA Sequence

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