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MON1B MON1 homolog B, secretory trafficking associated [ Homo sapiens (human) ]

Gene ID: 22879, updated on 1-Jun-2020

Summary

Official Symbol
MON1Bprovided by HGNC
Official Full Name
MON1 homolog B, secretory trafficking associatedprovided by HGNC
Primary source
HGNC:HGNC:25020
See related
Ensembl:ENSG00000103111 MIM:608954
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SRG1; HSRG1; SAND2
Expression
Ubiquitous expression in prostate (RPKM 20.4), thyroid (RPKM 15.6) and 25 other tissues See more
Orthologs

Genomic context

See MON1B in Genome Data Viewer
Location:
16q23.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (77191190..77202398)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (77224821..77233543)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene mitotic spindle assembly checkpoint protein MAD2A pseudogene Neighboring gene microRNA 4719 Neighboring gene synaptonemal complex central element protein 1 like Neighboring gene vomeronasal 2 receptor 10, pseudogene Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 18

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
early viral transcription IDA
Inferred from Direct Assay
more info
PubMed 
late viral transcription IDA
Inferred from Direct Assay
more info
PubMed 
protein targeting to vacuole IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Mon1-Ccz1 complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
vacuolar fusion protein MON1 homolog B
Names
HSV-1 stimulation-related gene 1 protein
HSV-I stimulating-related protein
MON1 secretory trafficking family member B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286639.2NP_001273568.1  vacuolar fusion protein MON1 homolog B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC009139
    Consensus CDS
    CCDS67083.1
    UniProtKB/Swiss-Prot
    Q7L1V2
    UniProtKB/TrEMBL
    B4DKA0, E7EW32, Q6ZR87
    Related
    ENSP00000404053.2, ENST00000439557.6
    Conserved Domains (1) summary
    pfam03164
    Location:48416
    Mon1; Trafficking protein Mon1
  2. NM_001286640.2NP_001273569.1  vacuolar fusion protein MON1 homolog B isoform 3

    See identical proteins and their annotated locations for NP_001273569.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC009139
    Consensus CDS
    CCDS67082.1
    UniProtKB/Swiss-Prot
    Q7L1V2
    UniProtKB/TrEMBL
    Q6ZR87
    Related
    ENSP00000444881.1, ENST00000545553.1
    Conserved Domains (1) summary
    pfam03164
    Location:9379
    Mon1; Trafficking protein Mon1
  3. NM_014940.4NP_055755.1  vacuolar fusion protein MON1 homolog B isoform 1

    See identical proteins and their annotated locations for NP_055755.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC009139
    Consensus CDS
    CCDS10925.1
    UniProtKB/Swiss-Prot
    Q7L1V2
    UniProtKB/TrEMBL
    Q6ZR87
    Related
    ENSP00000248248.3, ENST00000248248.8
    Conserved Domains (1) summary
    pfam03164
    Location:108525
    Mon1; Trafficking protein Mon1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    77191190..77202398
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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