Format

Send to:

Choose Destination

TRAPPC8 trafficking protein particle complex 8 [ Homo sapiens (human) ]

Gene ID: 22878, updated on 1-Jun-2020

Summary

Official Symbol
TRAPPC8provided by HGNC
Official Full Name
trafficking protein particle complex 8provided by HGNC
Primary source
HGNC:HGNC:29169
See related
Ensembl:ENSG00000153339 MIM:614136
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GSG1; TRS85; HsT2706; KIAA1012
Expression
Ubiquitous expression in testis (RPKM 23.5), thyroid (RPKM 10.8) and 25 other tissues See more
Orthologs

Genomic context

See TRAPPC8 in Genome Data Viewer
Location:
18q12.1
Exon count:
32
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (31829197..31943128, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (29409136..29523175, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene golgi SNAP receptor complex member 2 pseudogene Neighboring gene solute carrier family 25 member 52 Neighboring gene family with sequence similarity 76 member A pseudogene Neighboring gene RNA, U6 small nuclear 1050, pseudogene Neighboring gene epsin 2 pseudogene Neighboring gene phosphogluconate dehydrogenase pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of trafficking protein particle complex 8 (TRAPPC8) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1012, MGC71660

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagy of peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization by the Cvt pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization to phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
TRAPP complex IDA
Inferred from Direct Assay
more info
PubMed 
TRAPPIII protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
trafficking protein particle complex subunit 8
Names
general sporulation gene 1 homolog
protein TRS85 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014939.5NP_055754.3  trafficking protein particle complex subunit 8

    Status: VALIDATED

    Source sequence(s)
    AC009831, AC022960
    Consensus CDS
    CCDS11901.1
    Related
    ENSP00000283351.4, ENST00000283351.9

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    31829197..31943128 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025617.2XP_016881106.1  trafficking protein particle complex subunit 8 isoform X7

  2. XM_017025616.2XP_016881105.1  trafficking protein particle complex subunit 8 isoform X4

  3. XM_011525884.3XP_011524186.1  trafficking protein particle complex subunit 8 isoform X6

    Conserved Domains (1) summary
    pfam12739
    Location:158605
    TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit
  4. XM_005258234.3XP_005258291.1  trafficking protein particle complex subunit 8 isoform X3

    Conserved Domains (1) summary
    pfam12739
    Location:158605
    TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit
  5. XM_005258233.3XP_005258290.1  trafficking protein particle complex subunit 8 isoform X1

    Conserved Domains (1) summary
    pfam12739
    Location:158605
    TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit
  6. XM_017025615.1XP_016881104.1  trafficking protein particle complex subunit 8 isoform X2

    Related
    ENSP00000463764.1, ENST00000582539.5
  7. XM_005258235.3XP_005258292.1  trafficking protein particle complex subunit 8 isoform X8

    Conserved Domains (1) summary
    pfam12739
    Location:14330
    TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit
  8. XM_006722420.4XP_006722483.1  trafficking protein particle complex subunit 8 isoform X5

    Conserved Domains (1) summary
    pfam12739
    Location:158605
    TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

RNA

  1. XR_001753169.2 RNA Sequence

    Related
    ENST00000580104.5
  2. XR_001753167.2 RNA Sequence

  3. XR_001753168.2 RNA Sequence

Support Center