Rspo4 R-spondin 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rspo4provided by MGI
Official Full Name: R-spondin 4provided by MGI
Primary source: MGI:MGI:1924467
See related: Ensembl:ENSMUSG00000032852 AllianceGenome:MGI:1924467
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A730099F22; A930029K19Rik
Summary: Predicted to enable signaling receptor binding activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within nail development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including embryo ectoderm; limb; lower urogenital tract; tooth; and urethra of male. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 4. Orthologous to human RSPO4 (R-spondin 4). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Low expression observed in reference dataset See more
Orthologs: all
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Genomic context

Location:: 2 G3; 2 74.83 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (151684571..151716588)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (151842647..151874668)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rspo1/Rspo3-LGR4 signaling inhibits hepatic cholesterol synthesis through the AMPKalpha-SREBP2 pathway.
Title: Rspo1/Rspo3-LGR4 signaling inhibits hepatic cholesterol synthesis through the AMPKα-SREBP2 pathway.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:487711

D2Mit26 (e-PCR), detects polymorphism
- UniSTS:129141

Rspo4 (e-PCR), detects polymorphism
- UniSTS:527528

Rspo4 (e-PCR), detects polymorphism
- UniSTS:498604

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in limb development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nail development	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in non-collagenous component of interstitial matrix	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: R-spondin-4

Names: R-spondin family, member 4; R-spondin-like protein; cristin-4; cysteine-rich and single thrombospondin domain-containing protein 4; mCristin-4; roof plate-specific spondin-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001040689.1 → NP_001035779.1 R-spondin-4 precursor

See identical proteins and their annotated locations for NP_001035779.1

Status: VALIDATED

Source sequence(s)

AL845480

Consensus CDS

CCDS38272.1

UniProtKB/Swiss-Prot

Q8BJ73

UniProtKB/TrEMBL

A0AUN1, Q0P5Y9

Related

ENSMUSP00000041578.4, ENSMUST00000042217.5

Conserved Domains (2) summary

smart00261
Location:85 → 126

FU; Furin-like repeats

pfam15913
Location:35 → 138

Furin-like_2; Furin-like repeat, cysteine-rich

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

151684571..151716588

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006499308.5 → XP_006499371.1 R-spondin-4 isoform X1

UniProtKB/TrEMBL

A0AUN1

Related

ENSMUSP00000343085.1, ENSMUST00000564722.1

Conserved Domains (1) summary

pfam15913
Location:34 → 137

Furin-like_2; Furin-like repeat, cysteine-rich