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INPP5F inositol polyphosphate-5-phosphatase F [ Homo sapiens (human) ]

Gene ID: 22876, updated on 9-Feb-2026
Official Symbol
INPP5Fprovided by HGNC
Official Full Name
inositol polyphosphate-5-phosphatase Fprovided by HGNC
Primary source
HGNC:HGNC:17054
See related
Ensembl:ENSG00000198825 MIM:609389; AllianceGenome:HGNC:17054
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SAC2; hSAC2; MSTP007; MSTPO47
Summary
The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
Expression
Broad expression in brain (RPKM 17.8), testis (RPKM 4.5) and 22 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See INPP5F in Genome Data Viewer
Location:
10q26.11
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (119726050..119829147)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (120623626..120726730)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (121485562..121588659)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902513 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:121443219-121443398 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:121446148-121447084 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:121447085-121448021 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121451095-121451594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4129 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4130 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4131 Neighboring gene thioredoxin pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:121471328-121471517 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:121480870-121481758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4132 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2881 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:121492744-121493244 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:121497641-121498186 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:121498187-121498732 Neighboring gene Sharpr-MPRA regulatory region 1472 Neighboring gene RNA, 7SL, cytoplasmic 846, pseudogene Neighboring gene Sharpr-MPRA regulatory region 8600 Neighboring gene uncharacterized LOC105378513 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2882 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2883 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_10180 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_10184 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:121575109-121575271 Neighboring gene phosphatase and actin regulator 2 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:121610009-121610508 Neighboring gene minichromosome maintenance complex binding protein Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_10254 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2884 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4133 Neighboring gene NANOG hESC enhancer GRCh37_chr10:121648618-121649156 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:121650957-121651468 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:121651469-121651979 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:121651980-121652490 Neighboring gene SEC23 interacting protein Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_10320 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_10351

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Parkinson's Disease rs117896735 Variant Regulates INPP5F Expression in Brain Tissues and Increases Risk of Alzheimer's Disease. Xue F, et al. J Alzheimers Dis, 2022. PMID 35848021
  2. Gene expression of INPP5F as an independent prognostic marker in fludarabine-based therapy of chronic lymphocytic leukemia. Palermo G, et al. Blood Cancer J, 2015 Oct 2. PMID 26430724, Free PMC Article
  3. Identification and characterization of a sac domain-containing phosphoinositide 5-phosphatase. Minagawa T, et al. J Biol Chem, 2001 Jun 22. PMID 11274189
  4. Root hair defective4 encodes a phosphatidylinositol-4-phosphate phosphatase required for proper root hair development in Arabidopsis thaliana. Thole JM, et al. Plant Cell, 2008 Feb. PMID 18281508, Free PMC Article
  5. Inpp5f is a polyphosphoinositide phosphatase that regulates cardiac hypertrophic responsiveness. Zhu W, et al. Circ Res, 2009 Dec 4. PMID 19875726, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Parkinson's Disease rs117896735 Variant Regulates INPP5F Expression in Brain Tissues and Increases Risk of Alzheimer's Disease.
    Title: Parkinson's Disease rs117896735 Variant Regulates INPP5F Expression in Brain Tissues and Increases Risk of Alzheimer's Disease.
  2. Imprinting aberrations of SNRPN, ZAC1 and INPP5F genes involved in the pathogenesis of congenital heart disease with extracardiac malformations.
    Title: Imprinting aberrations of SNRPN, ZAC1 and INPP5F genes involved in the pathogenesis of congenital heart disease with extracardiac malformations.
  3. we identified inositol polyphosphate-5-phosphatase F (INPP5F) as a prognostic factor for progression-free survival in Chronic lymphocytic leukemia
    Title: Gene expression of INPP5F as an independent prognostic marker in fludarabine-based therapy of chronic lymphocytic leukemia.
  4. These findings suggest that INPP5F is a potential tumor suppressor in gliomas via inhibition of STAT3 pathway, and that deregulation of INPP5F may lead to contribution to gliomagenesis.
    Title: Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity.
  5. Sac2 colocalizes with early endosomal markers and is recruited to transferrin-containing vesicles during endocytic recycling.
    Title: Spatiotemporal control of phosphatidylinositol 4-phosphate by Sac2 regulates endocytic recycling.
  6. Inpp5f is a polyphosphoinositide phosphatase that regulates cardiac hypertrophic responsiveness.
    Title: Inpp5f is a polyphosphoinositide phosphatase that regulates cardiac hypertrophic responsiveness.
  7. Observational study of gene-disease association. (HuGE Navigator)
    Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Replication interactions

Interaction Pubs
Knockdown of inositol polyphosphate-5-phosphatase F (INPP5F) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ13081, KIAA0966, MGC59773, MGC131851

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol monophosphate 4-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phosphate 4-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol phosphate 4-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phosphate 4-phosphatase activity TAS
Traceable Author Statement
more info
  
NOT enables phosphatidylinositol phosphate 5-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol phosphate 5-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-4-phosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4-phosphate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in adult locomotory behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in cardiac muscle hypertrophy in response to stress ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in clathrin-dependent endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in clathrin-dependent endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of axon regeneration IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of axon regeneration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphatidylinositol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol biosynthetic process TAS
Traceable Author Statement
more info
  
involved_in phosphatidylinositol catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of receptor recycling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of receptor recycling IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell motility IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of endocytic recycling IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of endocytic recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
  
is_active_in clathrin-coated endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in clathrin-coated endocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in clathrin-coated endocytic vesicle IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with clathrin-coated pit IDA
Inferred from Direct Assay
more info
 PubMed 
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome membrane TAS
Traceable Author Statement
more info
  
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  
located_in recycling endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in recycling endosome IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
phosphatidylinositide 4-phosphatase SAC2; phosphatidylinositide phosphatase SAC2
Names
Sac domain-containing inositol phosphatase 2
sac domain-containing phosphoinositide 4-phosphatase 2
sac domain-containing phosphoinositide 5-phosphatase 2
NP_001230123.1
NP_001230124.1
NP_001427929.1
NP_001427930.1
NP_001427931.1
NP_001427932.1
NP_001427933.1
NP_001427934.1
NP_001427935.1
NP_001427936.1
NP_001427937.1
NP_001427938.1
NP_001427939.1
NP_001427940.1
NP_001427941.1
NP_001427942.1
NP_001427943.1
NP_001427944.1
NP_001427945.1
NP_001427946.1
NP_001427947.1
NP_001427948.1
NP_001427949.1
NP_001427950.1
NP_001427951.1
NP_001427952.1
NP_055752.1
XP_011537829.2
XP_011537830.1
XP_047280790.1
XP_054221199.1
XP_054221200.1
XP_054221202.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_044999.2 RefSeqGene

    Range
    26656..129753
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1061

mRNA and Protein(s)

  1. NM_001243194.2 → NP_001230123.1  phosphatidylinositide 4-phosphatase SAC2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC027672, AL133461, CN362016, DN992317
    Consensus CDS
    CCDS58098.1
    UniProtKB/Swiss-Prot
    Q9Y2H2
    Related
    ENSP00000496955.1, ENST00000650409.1
    Conserved Domains (1) summary
    pfam12456
    Location:19 → 87
    hSac2; Inositol phosphatase

  2. NM_001243195.2 → NP_001230124.1  phosphatidylinositide 4-phosphatase SAC2 isoform 3

    See identical proteins and their annotated locations for NP_001230124.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and lacks a portion of the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AI492073, AI783668, AL158014, BC052367, DB636424
    Consensus CDS
    CCDS81513.1
    UniProtKB/Swiss-Prot
    Q9Y2H2
    Related
    ENSP00000489864.1, ENST00000369081.3
    Conserved Domains (1) summary
    cl27434
    Location:50 → 199
    Syja_N; SacI homology domain

  3. NM_001441000.1 → NP_001427929.1  phosphatidylinositide 4-phosphatase SAC2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC027672, AL133461, AL158014
    UniProtKB/TrEMBL
    A0A3B3IRJ9

  4. NM_001441001.1 → NP_001427930.1  phosphatidylinositide 4-phosphatase SAC2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC027672, AL133461, AL158014
    UniProtKB/TrEMBL
    A0A3B3IRJ9

  5. NM_001441002.1 → NP_001427931.1  phosphatidylinositide 4-phosphatase SAC2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC027672, AL133461, AL158014
    UniProtKB/TrEMBL
    A0A3B3IRJ9

  6. NM_001441003.1 → NP_001427932.1  phosphatidylinositide 4-phosphatase SAC2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC027672, AL133461, AL158014
    UniProtKB/TrEMBL
    A0A3B3IRJ9
    Related
    ENSP00000565176.1, ENST00000895117.1

  7. NM_001441004.1 → NP_001427933.1  phosphatidylinositide 4-phosphatase SAC2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC027672, AL133461, AL158014
    UniProtKB/TrEMBL
    A0A3B3IRJ9

  8. NM_001441005.1 → NP_001427934.1  phosphatidylinositide 4-phosphatase SAC2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC027672, AL133461, AL158014
    UniProtKB/TrEMBL
    A0A3B3IRJ9

  9. NM_001441006.1 → NP_001427935.1  phosphatidylinositide 4-phosphatase SAC2 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC027672, AL133461, AL158014
    UniProtKB/TrEMBL
    A0A3B3IRJ9
    Related
    ENSP00000565177.1, ENST00000895118.1

  10. NM_001441007.1 → NP_001427936.1  phosphatidylinositide 4-phosphatase SAC2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC027672, AL133461, AL158014
    UniProtKB/TrEMBL
    A0A3B3IRJ9
    Related
    ENSP00000634626.1, ENST00000964567.1

  11. NM_001441008.1 → NP_001427937.1  phosphatidylinositide 4-phosphatase SAC2 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC027672, AL133461, AL158014
    UniProtKB/TrEMBL
    A0A3B3IRJ9

  12. NM_001441009.1 → NP_001427938.1  phosphatidylinositide 4-phosphatase SAC2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC027672, AL133461, AL158014
    UniProtKB/TrEMBL
    A0A3B3IRJ9, A0A3B3ITL0

  13. NM_001441010.1 → NP_001427939.1  phosphatidylinositide 4-phosphatase SAC2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC027672, AL133461, AL158014
    UniProtKB/TrEMBL
    A0A3B3IRJ9, A0A3B3ITL0

  14. NM_001441011.1 → NP_001427940.1  phosphatidylinositide 4-phosphatase SAC2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC027672, AL133461, AL158014
    UniProtKB/TrEMBL
    A0A3B3IRJ9, A0A3B3ITL0

  15. NM_001441012.1 → NP_001427941.1  phosphatidylinositide 4-phosphatase SAC2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC027672, AL133461, AL158014
    UniProtKB/TrEMBL
    A0A3B3IRJ9, A0A3B3ITL0
    Related
    ENSP00000497846.1, ENST00000649454.1

  16. NM_001441013.1 → NP_001427942.1  phosphatidylinositide 4-phosphatase SAC2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC027672, AL133461, AL158014
    UniProtKB/TrEMBL
    A0A3B3IRJ9, A0A3B3ITL0

  17. NM_001441014.1 → NP_001427943.1  phosphatidylinositide 4-phosphatase SAC2 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC027672, AL133461, AL158014
    UniProtKB/TrEMBL
    A0A3B3IRJ9
    Related
    ENSP00000565175.1, ENST00000895116.1

  18. NM_001441015.1 → NP_001427944.1  phosphatidylinositide 4-phosphatase SAC2 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC027672, AL133461, AL158014
    UniProtKB/TrEMBL
    A0A3B3IRJ9

  19. NM_001441016.1 → NP_001427945.1  phosphatidylinositide 4-phosphatase SAC2 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC027672, AL133461, AL158014
    UniProtKB/TrEMBL
    A0A3B3IRJ9

  20. NM_001441017.1 → NP_001427946.1  phosphatidylinositide 4-phosphatase SAC2 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC027672, AL133461, AL158014
    UniProtKB/TrEMBL
    A0A3B3IRJ9

  21. NM_001441018.1 → NP_001427947.1  phosphatidylinositide 4-phosphatase SAC2 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC027672, AL133461, AL158014
    UniProtKB/TrEMBL
    A0A3B3ITR9

  22. NM_001441019.1 → NP_001427948.1  phosphatidylinositide 4-phosphatase SAC2 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC027672, AL133461, AL158014
    UniProtKB/TrEMBL
    A0A3B3ITR9
    Related
    ENSP00000498016.1, ENST00000649957.1

  23. NM_001441020.1 → NP_001427949.1  phosphatidylinositide 4-phosphatase SAC2 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC027672, AL133461, AL158014
    UniProtKB/TrEMBL
    A0A3B3ISI3, A0A3B3ITR9
    Related
    ENSP00000497368.1, ENST00000649251.1

  24. NM_001441021.1 → NP_001427950.1  phosphatidylinositide 4-phosphatase SAC2 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC027672, AL133461, AL158014

  25. NM_001441022.1 → NP_001427951.1  phosphatidylinositide 4-phosphatase SAC2 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC027672, AL133461, AL158014

  26. NM_001441023.1 → NP_001427952.1  phosphatidylinositide 4-phosphatase SAC2 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AL133461, AL158014
    UniProtKB/TrEMBL
    A0A3B3ITR9

  27. NM_014937.4 → NP_055752.1  phosphatidylinositide 4-phosphatase SAC2 isoform 1

    See identical proteins and their annotated locations for NP_055752.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB023183, AC027672, AL158014
    Consensus CDS
    CCDS7616.1
    UniProtKB/Swiss-Prot
    B3KRF1, D3DRD1, Q2T9J4, Q5W135, Q5W136, Q6NVY2, Q86U97, Q9H3D9, Q9NT51, Q9Y2H2
    UniProtKB/TrEMBL
    A0A3B3IRJ9
    Related
    ENSP00000497527.1, ENST00000650623.2
    Conserved Domains (2) summary
    COG5329
    Location:50 → 567
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    pfam12456
    Location:596 → 697
    hSac2; Inositol phosphatase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    119726050..119829147
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424834.1 → XP_047280790.1  phosphatidylinositide phosphatase SAC2 isoform X2

    UniProtKB/TrEMBL
    A0A3B3IRJ9, A0A3B3ITL0

  2. XM_011539527.4 → XP_011537829.2  phosphatidylinositide phosphatase SAC2 isoform X1

    UniProtKB/TrEMBL
    A0A3B3IRJ9

  3. XM_011539528.4 → XP_011537830.1  phosphatidylinositide phosphatase SAC2 isoform X2

    See identical proteins and their annotated locations for XP_011537830.1

    UniProtKB/TrEMBL
    A0A3B3IRJ9, A0A3B3ITL0
    Conserved Domains (2) summary
    pfam02383
    Location:73 → 319
    Syja_N; SacI homology domain
    pfam12456
    Location:499 → 601
    hSac2; Inositol phosphatase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    120623626..120726730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054365225.1 → XP_054221200.1  phosphatidylinositide phosphatase SAC2 isoform X2

    UniProtKB/TrEMBL
    A0A3B3IRJ9, A0A3B3ITL0

  2. XM_054365224.1 → XP_054221199.1  phosphatidylinositide phosphatase SAC2 isoform X1

    UniProtKB/TrEMBL
    A0A3B3IRJ9

  3. XM_054365227.1 → XP_054221202.1  phosphatidylinositide phosphatase SAC2 isoform X2

    UniProtKB/TrEMBL
    A0A3B3IRJ9, A0A3B3ITL0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y2H2.3 GenPept UniProtKB/Swiss-Prot:Q9Y2H2

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