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PPP6R1 protein phosphatase 6 regulatory subunit 1 [ Homo sapiens (human) ]

Gene ID: 22870, updated on 24-Nov-2020

Summary

Official Symbol
PPP6R1provided by HGNC
Official Full Name
protein phosphatase 6 regulatory subunit 1provided by HGNC
Primary source
HGNC:HGNC:29195
See related
Ensembl:ENSG00000105063 MIM:610875
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP6R1; SAPS1; SAP190; KIAA1115
Summary
Protein phosphatase regulatory subunits, such as SAPS1, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS1 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010]
Expression
Broad expression in testis (RPKM 56.4), lymph node (RPKM 37.5) and 24 other tissues See more
Orthologs

Genomic context

See PPP6R1 in Genome Data Viewer
Location:
19q13.42
Exon count:
24
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (55229779..55259017, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55741147..55770038, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase receptor type H Neighboring gene transmembrane protein 86B Neighboring gene microRNA 6804 Neighboring gene microRNA 6802 Neighboring gene microRNA 6803 Neighboring gene HSPA (Hsp70) binding protein 1 Neighboring gene BR serine/threonine kinase 1 Neighboring gene transmembrane protein 150B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138185, MGC142003

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
COPII vesicle coating TAS
Traceable Author Statement
more info
 
regulation of phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein phosphatase 6 regulatory subunit 1
Names
SAPS domain family, member 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014931.4NP_055746.3  serine/threonine-protein phosphatase 6 regulatory subunit 1

    See identical proteins and their annotated locations for NP_055746.3

    Status: VALIDATED

    Source sequence(s)
    AC010327, AC116342, AL544921, BC002799, BG772019
    Consensus CDS
    CCDS46186.1
    UniProtKB/Swiss-Prot
    Q9UPN7
    Related
    ENSP00000414202.1, ENST00000412770.7
    Conserved Domains (2) summary
    PHA03195
    Location:742875
    PHA03195; tegument protein VP11/12; Provisional
    pfam04499
    Location:128519
    SAPS; SIT4 phosphatase-associated protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    55229779..55259017 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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