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FNDC3A fibronectin type III domain containing 3A [ Homo sapiens (human) ]

Gene ID: 22862, updated on 22-Sep-2022

Summary

Official Symbol
FNDC3Aprovided by HGNC
Official Full Name
fibronectin type III domain containing 3Aprovided by HGNC
Primary source
HGNC:HGNC:20296
See related
Ensembl:ENSG00000102531 MIM:615794; AllianceGenome:HGNC:20296
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HUGO; FNDC3; bA203I16.1; bA203I16.5
Summary
Enables RNA binding activity. Predicted to act upstream of or within several processes, including Sertoli cell development; fertilization; and spermatid development. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 26.8), adrenal (RPKM 18.9) and 25 other tissues See more
Orthologs
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Genomic context

See FNDC3A in Genome Data Viewer
Location:
13q14.2
Exon count:
31
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (48975291..49209779)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (48197201..48431085)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (49550048..49783915)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene proteasome activator subunit 2 pseudogene 2 Neighboring gene uncharacterized LOC107984559 Neighboring gene RNA, U6 small nuclear 60, pseudogene Neighboring gene RAD17 pseudogene 2 Neighboring gene RNY3 pseudogene 2 Neighboring gene COX7C pseudogene 1 Neighboring gene 2-oxoglutarate and iron dependent oxygenase domain containing 1 pseudogene 1 Neighboring gene motilin receptor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31509, KIAA0970

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
Process Evidence Code Pubs
involved_in Sertoli cell development IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in fertilization IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatid development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in vesicle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
fibronectin type-III domain-containing protein 3A
Names
human gene expressed in odontoblasts

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079673.2NP_001073141.1  fibronectin type-III domain-containing protein 3A isoform 1

    See identical proteins and their annotated locations for NP_001073141.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 3 encode the same isoform.
    Source sequence(s)
    AJ749706, AL137000, BM973827
    Consensus CDS
    CCDS41886.1
    UniProtKB/Swiss-Prot
    Q9H1W1, Q9Y2H6
    UniProtKB/TrEMBL
    A0A024RDT9
    Related
    ENSP00000417257.1, ENST00000492622.6
    Conserved Domains (1) summary
    cd00063
    Location:371462
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. NM_001278438.2NP_001265367.1  fibronectin type-III domain-containing protein 3A isoform 1

    See identical proteins and their annotated locations for NP_001265367.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR exon, compared to variant 1. Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    BC060816, BC132812, BM973827, DB460317
    Consensus CDS
    CCDS41886.1
    UniProtKB/Swiss-Prot
    Q9H1W1, Q9Y2H6
    UniProtKB/TrEMBL
    A0A024RDT9
    Related
    ENSP00000441831.1, ENST00000541916.5
    Conserved Domains (1) summary
    cd00063
    Location:371462
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  3. NM_014923.5NP_055738.3  fibronectin type-III domain-containing protein 3A isoform 2

    See identical proteins and their annotated locations for NP_055738.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AJ749707, BC051029, BM973827
    Consensus CDS
    CCDS9413.2
    UniProtKB/Swiss-Prot
    Q9Y2H6
    UniProtKB/TrEMBL
    A0A024RDV5
    Related
    ENSP00000381362.3, ENST00000398316.7
    Conserved Domains (1) summary
    cd00063
    Location:315406
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RNA

  1. NR_103528.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate 5' exon and an alternate splice site in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC051029, BM973827, DB460317
    Related
    ENST00000484074.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    48975291..49209779
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020440.3XP_016875929.1  fibronectin type-III domain-containing protein 3A isoform X1

    UniProtKB/Swiss-Prot
    Q9H1W1, Q9Y2H6
    UniProtKB/TrEMBL
    A0A024RDT9
    Conserved Domains (1) summary
    cd00063
    Location:371462
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. XM_017020443.2XP_016875932.1  fibronectin type-III domain-containing protein 3A isoform X3

    Conserved Domains (1) summary
    cd00063
    Location:371462
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  3. XM_011534997.4XP_011533299.1  fibronectin type-III domain-containing protein 3A isoform X2

    See identical proteins and their annotated locations for XP_011533299.1

    UniProtKB/Swiss-Prot
    Q9Y2H6
    Conserved Domains (1) summary
    cd00063
    Location:307398
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    48197201..48431085
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)