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Mavs mitochondrial antiviral signaling protein [ Mus musculus (house mouse) ]

Gene ID: 228607, updated on 8-Feb-2024

Summary

Official Symbol
Mavsprovided by MGI
Official Full Name
mitochondrial antiviral signaling proteinprovided by MGI
Primary source
MGI:MGI:2444773
See related
Ensembl:ENSMUSG00000037523 AllianceGenome:MGI:2444773
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Visa; IPS-1; cardif; D430028G21Rik
Summary
Enables signaling adaptor activity. Involved in several processes, including negative regulation of viral genome replication; positive regulation of myeloid dendritic cell cytokine production; and regulation of peroxisome organization. Acts upstream of or within RIG-I signaling pathway; positive regulation of defense response to virus by host; and positive regulation of type I interferon production. Located in mitochondrion and peroxisome. Orthologous to human MAVS (mitochondrial antiviral signaling protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver adult (RPKM 50.6), kidney adult (RPKM 46.8) and 25 other tissues See more
Orthologs
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Genomic context

See Mavs in Genome Data Viewer
Location:
2 F1; 2 63.3 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (131075445..131089945)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (131234063..131248025)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cell division cycle 25B Neighboring gene STARR-positive B cell enhancer mm9_chr2:131026522-131026822 Neighboring gene STARR-positive B cell enhancer ABC_E10146 Neighboring gene adaptor-related protein 5 complex, sigma 1 subunit Neighboring gene STARR-seq mESC enhancer starr_05703 Neighboring gene STARR-positive B cell enhancer ABC_E4499 Neighboring gene STARR-positive B cell enhancer ABC_E5984 Neighboring gene STARR-seq mESC enhancer starr_05706 Neighboring gene STARR-seq mESC enhancer starr_05707 Neighboring gene pantothenate kinase 2 Neighboring gene microRNA 103-2 Neighboring gene ring finger protein 24 Neighboring gene small nuclear ribonucleoprotein E, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC25836

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CARD domain binding ISO
Inferred from Sequence Orthology
more info
 
enables RIG-I binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables molecular condensate scaffold activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling adaptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within RIG-I signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in activation of innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to exogenous dsRNA ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to interferon-beta ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in cytoplasmic pattern recognition receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_positive_effect innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of viral genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of IP-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NLRP3 inflammasome complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of NLRP3 inflammasome complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemokine (C-C motif) ligand 5 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of defense response to virus by host IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of defense response to virus by host ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of interferon-alpha production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interferon-alpha production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of myeloid dendritic cell cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of type I interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein tetramerization ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in regulation of peroxisome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of peroxisome organization ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitochondrial antiviral-signaling protein
Names
CARD adapter inducing interferon beta
IFN-beta promoter stimulator-1
interferon beta promoter stimulator protein 1
mitochondrial anti-viral signaling protein
virus-induced signaling adapter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001206382.1NP_001193311.1  mitochondrial antiviral-signaling protein isoform 2

    See identical proteins and their annotated locations for NP_001193311.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 3 and 4 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK153748, AL808128
    UniProtKB/TrEMBL
    Q3U5B1
  2. NM_001206383.1NP_001193312.1  mitochondrial antiviral-signaling protein isoform 2

    See identical proteins and their annotated locations for NP_001193312.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 3 and 4 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL808128
    UniProtKB/TrEMBL
    Q3U5B1
  3. NM_001206385.1NP_001193314.1  mitochondrial antiviral-signaling protein isoform 1

    See identical proteins and their annotated locations for NP_001193314.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK028421, AK153748, AL808128
    Consensus CDS
    CCDS16760.1
    UniProtKB/Swiss-Prot
    Q8VCF0
    Related
    ENSMUSP00000038339.6, ENSMUST00000041362.12
    Conserved Domains (1) summary
    cd08811
    Location:393
    CARD_IPS1; Caspase activation and recruitment domain (CARD) found in IPS-1
  4. NM_144888.2NP_659137.1  mitochondrial antiviral-signaling protein isoform 1

    See identical proteins and their annotated locations for NP_659137.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AL808128
    Consensus CDS
    CCDS16760.1
    UniProtKB/Swiss-Prot
    Q8VCF0
    Related
    ENSMUSP00000105828.3, ENSMUST00000110199.3
    Conserved Domains (1) summary
    cd08811
    Location:393
    CARD_IPS1; Caspase activation and recruitment domain (CARD) found in IPS-1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    131075445..131089945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161358.1XP_036017251.1  mitochondrial antiviral-signaling protein isoform X1

    UniProtKB/TrEMBL
    Q3U5B1
  2. XM_036161359.1XP_036017252.1  mitochondrial antiviral-signaling protein isoform X1

    UniProtKB/TrEMBL
    Q3U5B1