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FKBP2 FKBP prolyl isomerase 2 [ Homo sapiens (human) ]

Gene ID: 2286, updated on 7-Dec-2018

Summary

Official Symbol
FKBP2provided by HGNC
Official Full Name
FKBP prolyl isomerase 2provided by HGNC
Primary source
HGNC:HGNC:3718
See related
Ensembl:ENSG00000173486 MIM:186946
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPIase; FKBP-13
Summary
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]
Expression
Ubiquitous expression in kidney (RPKM 33.5), thyroid (RPKM 33.5) and 25 other tissues See more
Orthologs

Genomic context

See FKBP2 in Genome Data Viewer
Location:
11q13.1
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (64240941..64244135)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64008413..64011607)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C4 Neighboring gene vascular endothelial growth factor B Neighboring gene uncharacterized LOC105369340 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14B Neighboring gene phospholipase C beta 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
FK506 binding TAS
Traceable Author Statement
more info
PubMed 
peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
protein peptidyl-prolyl isomerization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase FKBP2
Names
13 kDa FK506-binding protein
13 kDa FKBP
FK506 binding protein 2, 13kDa
FK506-binding protein 2
FKBP-2
PPIase FKBP2
epididymis secretory sperm binding protein
immunophilin FKBP13
proline isomerase
rapamycin-binding protein
rotamase
NP_001128680.1
NP_004461.2
NP_476433.1
XP_005273905.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135208.1NP_001128680.1  peptidyl-prolyl cis-trans isomerase FKBP2 precursor

    See identical proteins and their annotated locations for NP_001128680.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same isoform.
    Source sequence(s)
    AW450265, BU682774, M75099
    Consensus CDS
    CCDS8063.1
    UniProtKB/Swiss-Prot
    P26885
    UniProtKB/TrEMBL
    Q53XJ5
    Related
    ENSP00000398147.2, ENST00000449942.6
    Conserved Domains (1) summary
    pfam00254
    Location:42134
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
  2. NM_004470.4NP_004461.2  peptidyl-prolyl cis-trans isomerase FKBP2 precursor

    See identical proteins and their annotated locations for NP_004461.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same isoform.
    Source sequence(s)
    AP001453
    Consensus CDS
    CCDS8063.1
    UniProtKB/Swiss-Prot
    P26885
    UniProtKB/TrEMBL
    Q53XJ5
    Related
    ENSP00000310935.4, ENST00000309366.8
    Conserved Domains (1) summary
    pfam00254
    Location:42134
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
  3. NM_057092.2NP_476433.1  peptidyl-prolyl cis-trans isomerase FKBP2 precursor

    See identical proteins and their annotated locations for NP_476433.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same isoform.
    Source sequence(s)
    AW450265, BC003384
    Consensus CDS
    CCDS8063.1
    UniProtKB/Swiss-Prot
    P26885
    UniProtKB/TrEMBL
    Q53XJ5
    Related
    ENSP00000378046.3, ENST00000394540.3
    Conserved Domains (1) summary
    pfam00254
    Location:42134
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    64240941..64244135
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273848.3XP_005273905.1  peptidyl-prolyl cis-trans isomerase FKBP2 isoform X1

    See identical proteins and their annotated locations for XP_005273905.1

    UniProtKB/Swiss-Prot
    P26885
    UniProtKB/TrEMBL
    Q53XJ5
    Conserved Domains (1) summary
    pfam00254
    Location:42134
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
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