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ADGRL1 adhesion G protein-coupled receptor L1 [ Homo sapiens (human) ]

Gene ID: 22859, updated on 5-Sep-2021

Summary

Official Symbol
ADGRL1provided by HGNC
Official Full Name
adhesion G protein-coupled receptor L1provided by HGNC
Primary source
HGNC:HGNC:20973
See related
Ensembl:ENSG00000072071 MIM:616416
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CL1; LEC2; CIRL1; LPHN1
Summary
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]
Expression
Broad expression in brain (RPKM 19.5), fat (RPKM 7.9) and 22 other tissues See more
Orthologs
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Genomic context

See ADGRL1 in Genome Data Viewer
Location:
19p13.12
Exon count:
27
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (14147737..14206245, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (14258555..14316981, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene protein kinase cAMP-activated catalytic subunit alpha Neighboring gene ADGRL1 antisense RNA 1 Neighboring gene anti-silencing function 1B histone chaperone Neighboring gene RNA, 7SL, cytoplasmic 231, pseudogene Neighboring gene long intergenic non-protein coding RNA 1841 Neighboring gene long intergenic non-protein coding RNA 1842

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables cell adhesion molecule binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables latrotoxin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables latrotoxin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in presynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in synapse ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
adhesion G protein-coupled receptor L1
Names
CIRL-1
calcium-independent alpha-latrotoxin receptor 1
latrophilin-1
lectomedin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008701.3NP_001008701.1  adhesion G protein-coupled receptor L1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001008701.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB020628, AF307079, BC002974, BC072445
    Consensus CDS
    CCDS32928.1
    UniProtKB/Swiss-Prot
    O94910
    Related
    ENSP00000340688.5, ENST00000340736.10
    Conserved Domains (8) summary
    smart00303
    Location:798850
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:476539
    HormR; Domain present in hormone receptors
    PHA03247
    Location:398482
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:8571114
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:48128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11131474
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:549774
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
  2. NM_014921.5NP_055736.2  adhesion G protein-coupled receptor L1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_055736.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AB020628, AF307079, BC002974, BC072445
    Consensus CDS
    CCDS12307.1
    UniProtKB/Swiss-Prot
    O94910
    Related
    ENSP00000355328.2, ENST00000361434.7
    Conserved Domains (8) summary
    smart00303
    Location:793845
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:471534
    HormR; Domain present in hormone receptors
    PHA03247
    Location:393465
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:8521109
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:48128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11081469
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:544769
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:137393
    OLF; Olfactomedin-like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    14147737..14206245 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259818.3XP_005259875.1  adhesion G protein-coupled receptor L1 isoform X5

    See identical proteins and their annotated locations for XP_005259875.1

    Conserved Domains (8) summary
    smart00303
    Location:793845
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:471534
    HormR; Domain present in hormone receptors
    PHA03247
    Location:393465
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:8521109
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:48128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11081493
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:544769
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:137393
    OLF; Olfactomedin-like domain
  2. XM_011527798.2XP_011526100.1  adhesion G protein-coupled receptor L1 isoform X3

    See identical proteins and their annotated locations for XP_011526100.1

    Conserved Domains (8) summary
    smart00303
    Location:800852
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:478541
    HormR; Domain present in hormone receptors
    PHA03247
    Location:393497
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:8591116
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:48128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11151500
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:551776
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:137393
    OLF; Olfactomedin-like domain
  3. XM_011527796.2XP_011526098.1  adhesion G protein-coupled receptor L1 isoform X2

    See identical proteins and their annotated locations for XP_011526098.1

    Conserved Domains (8) summary
    smart00303
    Location:805857
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:483546
    HormR; Domain present in hormone receptors
    PHA03247
    Location:398502
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:8641121
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:48128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11201505
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:556781
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
  4. XM_017026477.1XP_016881966.1  adhesion G protein-coupled receptor L1 isoform X4

    Conserved Domains (8) summary
    smart00303
    Location:799851
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:477540
    HormR; Domain present in hormone receptors
    PHA03247
    Location:399471
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:8581115
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:48128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11141499
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:550775
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:143399
    OLF; Olfactomedin-like domain
  5. XM_017026479.1XP_016881968.1  adhesion G protein-coupled receptor L1 isoform X7

  6. XM_017026478.1XP_016881967.1  adhesion G protein-coupled receptor L1 isoform X6

    Conserved Domains (8) summary
    smart00303
    Location:806858
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:484547
    HormR; Domain present in hormone receptors
    PHA03247
    Location:399537
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:8651122
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:48128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11211482
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:557782
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:143399
    OLF; Olfactomedin-like domain
  7. XM_017026475.1XP_016881964.1  adhesion G protein-coupled receptor L1 isoform X1

    Conserved Domains (8) summary
    smart00303
    Location:806858
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:484547
    HormR; Domain present in hormone receptors
    PHA03247
    Location:399503
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:8651122
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:48128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11211506
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:557782
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:143399
    OLF; Olfactomedin-like domain
  8. XM_017026476.1XP_016881965.1  adhesion G protein-coupled receptor L1 isoform X1

    Conserved Domains (8) summary
    smart00303
    Location:806858
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:484547
    HormR; Domain present in hormone receptors
    PHA03247
    Location:399503
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:8651122
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:48128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11211506
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:557782
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:143399
    OLF; Olfactomedin-like domain
  9. XM_024451420.1XP_024307188.1  adhesion G protein-coupled receptor L1 isoform X1

    Conserved Domains (8) summary
    smart00303
    Location:806858
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:484547
    HormR; Domain present in hormone receptors
    PHA03247
    Location:399503
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:8651122
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:48128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11211506
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:557782
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:143399
    OLF; Olfactomedin-like domain
  10. XM_011527801.2XP_011526103.1  adhesion G protein-coupled receptor L1 isoform X8

    Conserved Domains (6) summary
    smart00303
    Location:725777
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:403466
    HormR; Domain present in hormone receptors
    pfam00002
    Location:7851020
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02354
    Location:10401425
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:477699
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:62318
    OLF; Olfactomedin-like domain
  11. XM_017026480.1XP_016881969.1  adhesion G protein-coupled receptor L1 isoform X9

  12. XM_017026481.1XP_016881970.1  adhesion G protein-coupled receptor L1 isoform X10

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_021160022.1 Reference GRCh38.p13 PATCHES

    Range
    359902..418328 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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