Format

Send to:

Choose Destination

ICK intestinal cell kinase [ Homo sapiens (human) ]

Gene ID: 22858, updated on 12-Aug-2018

Summary

Official Symbol
ICKprovided by HGNC
Official Full Name
intestinal cell kinaseprovided by HGNC
Primary source
HGNC:HGNC:21219
See related
Ensembl:ENSG00000112144 MIM:612325; Vega:OTTHUMG00000014870
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ECO; MRK; LCK2; EJM10
Summary
Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 9.9), placenta (RPKM 5.9) and 25 other tissues See more
Orthologs

Genomic context

See ICK in Genome Data Viewer
Location:
6p12.1
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (53001299..53061864, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (52866097..52926676, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase alpha 4 Neighboring gene RNA, 7SK small nuclear Neighboring gene F-box protein 9 Neighboring gene RNA, 7SL, cytoplasmic 244, pseudogene Neighboring gene glial cells missing homolog 1 Neighboring gene RNA, U6 small nuclear 464, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0936, MGC46090

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
intraciliary anterograde transport ISS
Inferred from Sequence or Structural Similarity
more info
 
intraciliary retrograde transport ISS
Inferred from Sequence or Structural Similarity
more info
 
intraciliary transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intraciliary transport ISS
Inferred from Sequence or Structural Similarity
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
ciliary basal body ISS
Inferred from Sequence or Structural Similarity
more info
 
ciliary base ISS
Inferred from Sequence or Structural Similarity
more info
 
ciliary tip IMP
Inferred from Mutant Phenotype
more info
PubMed 
cilium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cilium ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
fibrillar center IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase ICK
Names
MAK-related kinase
hICK
intestinal cell (MAK-like) kinase
laryngeal cancer kinase 2
serine/threonine protein kinase
NP_055735.1
NP_057597.2
XP_011512721.1
XP_011512722.1
XP_011512723.1
XP_016865974.1
XP_016865975.1
XP_016865976.1
XP_016865977.1
XP_016865978.1
XP_016865979.1
XP_016865980.1
XP_016865981.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012159.1 RefSeqGene

    Range
    5001..65503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014920.3NP_055735.1  serine/threonine-protein kinase ICK

    See identical proteins and their annotated locations for NP_055735.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB023153, DA456873
    Consensus CDS
    CCDS4949.1
    UniProtKB/Swiss-Prot
    Q9UPZ9
    UniProtKB/TrEMBL
    A0A024RD59
    Related
    ENSP00000263043.7, OTTHUMP00000016630, ENST00000350082.9, OTTHUMT00000040952
    Conserved Domains (2) summary
    smart00220
    Location:4284
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07830
    Location:4284
    STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases
  2. NM_016513.4NP_057597.2  serine/threonine-protein kinase ICK

    See identical proteins and their annotated locations for NP_057597.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an additional exon in the 5' UTR, as compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB023153, AK074892, DA456873
    Consensus CDS
    CCDS4949.1
    UniProtKB/Swiss-Prot
    Q9UPZ9
    UniProtKB/TrEMBL
    A0A024RD59, B3KQG4
    Related
    ENSP00000349458.3, ENST00000356971.3
    Conserved Domains (2) summary
    smart00220
    Location:4284
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07830
    Location:4284
    STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    53001299..53061864 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010490.1XP_016865979.1  serine/threonine-protein kinase ICK isoform X2

    UniProtKB/Swiss-Prot
    Q9UPZ9
    UniProtKB/TrEMBL
    A0A024RD59
    Conserved Domains (2) summary
    smart00220
    Location:4284
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07830
    Location:4284
    STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases
  2. XM_017010489.1XP_016865978.1  serine/threonine-protein kinase ICK isoform X2

    UniProtKB/Swiss-Prot
    Q9UPZ9
    UniProtKB/TrEMBL
    A0A024RD59
    Conserved Domains (2) summary
    smart00220
    Location:4284
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07830
    Location:4284
    STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases
  3. XM_011514420.2XP_011512722.1  serine/threonine-protein kinase ICK isoform X1

    See identical proteins and their annotated locations for XP_011512722.1

    Conserved Domains (2) summary
    smart00220
    Location:4284
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07830
    Location:4284
    STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases
  4. XM_017010486.1XP_016865975.1  serine/threonine-protein kinase ICK isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:4284
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07830
    Location:4284
    STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases
  5. XM_017010491.1XP_016865980.1  serine/threonine-protein kinase ICK isoform X2

    UniProtKB/Swiss-Prot
    Q9UPZ9
    UniProtKB/TrEMBL
    A0A024RD59
    Conserved Domains (2) summary
    smart00220
    Location:4284
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07830
    Location:4284
    STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases
  6. XM_017010492.1XP_016865981.1  serine/threonine-protein kinase ICK isoform X2

    UniProtKB/Swiss-Prot
    Q9UPZ9
    UniProtKB/TrEMBL
    A0A024RD59
    Conserved Domains (2) summary
    smart00220
    Location:4284
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07830
    Location:4284
    STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases
  7. XM_017010488.1XP_016865977.1  serine/threonine-protein kinase ICK isoform X2

    UniProtKB/Swiss-Prot
    Q9UPZ9
    UniProtKB/TrEMBL
    A0A024RD59
    Conserved Domains (2) summary
    smart00220
    Location:4284
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07830
    Location:4284
    STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases
  8. XM_011514419.1XP_011512721.1  serine/threonine-protein kinase ICK isoform X1

    See identical proteins and their annotated locations for XP_011512721.1

    Conserved Domains (2) summary
    smart00220
    Location:4284
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07830
    Location:4284
    STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases
  9. XM_011514421.1XP_011512723.1  serine/threonine-protein kinase ICK isoform X1

    See identical proteins and their annotated locations for XP_011512723.1

    Conserved Domains (2) summary
    smart00220
    Location:4284
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07830
    Location:4284
    STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases
  10. XM_017010487.1XP_016865976.1  serine/threonine-protein kinase ICK isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:4284
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07830
    Location:4284
    STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases
  11. XM_017010485.1XP_016865974.1  serine/threonine-protein kinase ICK isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:4284
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07830
    Location:4284
    STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases
Support Center