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Arhgap11a Rho GTPase activating protein 11A [ Mus musculus (house mouse) ]

Gene ID: 228482, updated on 11-Apr-2024

Summary

Official Symbol
Arhgap11aprovided by MGI
Official Full Name
Rho GTPase activating protein 11Aprovided by MGI
Primary source
MGI:MGI:2444300
See related
Ensembl:ENSMUSG00000041219 AllianceGenome:MGI:2444300
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0013; 6530401L14Rik
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in signal transduction. Predicted to be located in mitochondrial matrix and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to several human genes including ARHGAP11A (Rho GTPase activating protein 11A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 20.9), liver E14 (RPKM 13.4) and 15 other tissues See more
Orthologs
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Genomic context

Location:
2 E4; 2 57.47 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (113661837..113679006, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (113831492..113848661, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 46756 Neighboring gene secretogranin V Neighboring gene STARR-positive B cell enhancer mm9_chr2:113664128-113664429 Neighboring gene STARR-seq mESC enhancer starr_05402 Neighboring gene predicted gene, 30985 Neighboring gene predicted gene, 21596

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
rho GTPase-activating protein 11A
Names
GAP (1-12)
rho-type GTPase-activating protein 11A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181416.3NP_852081.2  rho GTPase-activating protein 11A

    See identical proteins and their annotated locations for NP_852081.2

    Status: VALIDATED

    Source sequence(s)
    AL772405, BC058105, BU052980
    Consensus CDS
    CCDS16562.1
    UniProtKB/Swiss-Prot
    A2AL17, Q6ZQL1, Q80Y19
    Related
    ENSMUSP00000099604.2, ENSMUST00000102545.8
    Conserved Domains (2) summary
    cd04394
    Location:46246
    RhoGAP-ARHGAP11A; RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing ...
    pfam16609
    Location:371464
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    113661837..113679006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)