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VASH1 vasohibin 1 [ Homo sapiens (human) ]

Gene ID: 22846, updated on 11-Jun-2021

Summary

Official Symbol
VASH1provided by HGNC
Official Full Name
vasohibin 1provided by HGNC
Primary source
HGNC:HGNC:19964
See related
Ensembl:ENSG00000071246 MIM:609011
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TTCP 1; KIAA1036
Expression
Ubiquitous expression in brain (RPKM 12.0), placenta (RPKM 11.8) and 25 other tissues See more
Orthologs
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Genomic context

See VASH1 in Genome Data Viewer
Location:
14q24.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (76761457..76783017)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (77227811..77249358)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene H1.8 linker histone pseudogene Neighboring gene uncharacterized LOC105370577 Neighboring gene VASH1 antisense RNA 1 Neighboring gene angel homolog 1 Neighboring gene leucine rich repeat containing 74A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metallocarboxypeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metallocarboxypeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in labyrinthine layer blood vessel development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of endothelial cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of lymphangiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of cellular senescence IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to wounding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tubulinyl-Tyr carboxypeptidase 1
Names
tubulin carboxypeptidase 1
tyrosine carboxypeptidase 1
NP_055724.1
XP_016876576.1
XP_016876577.1
XP_016876578.1
XP_016876579.1
XP_016876580.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014909.5NP_055724.1  tubulinyl-Tyr carboxypeptidase 1

    See identical proteins and their annotated locations for NP_055724.1

    Status: VALIDATED

    Source sequence(s)
    AB028959, AC007376, AL832588, BC051896, BE674799, BF741850
    Consensus CDS
    CCDS9851.1
    UniProtKB/Swiss-Prot
    Q7L8A9
    Related
    ENSP00000167106.4, ENST00000167106.9
    Conserved Domains (1) summary
    pfam14822
    Location:58302
    Vasohibin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    76761457..76783017
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021091.1XP_016876580.1  tubulinyl-Tyr carboxypeptidase 1 isoform X2

    Conserved Domains (1) summary
    pfam14822
    Location:1120
    Vasohibin
  2. XM_017021088.1XP_016876577.1  tubulinyl-Tyr carboxypeptidase 1 isoform X1

    Conserved Domains (1) summary
    pfam14822
    Location:1149
    Vasohibin
  3. XM_017021087.1XP_016876576.1  tubulinyl-Tyr carboxypeptidase 1 isoform X1

    Conserved Domains (1) summary
    pfam14822
    Location:1149
    Vasohibin
  4. XM_017021089.1XP_016876578.1  tubulinyl-Tyr carboxypeptidase 1 isoform X1

    Conserved Domains (1) summary
    pfam14822
    Location:1149
    Vasohibin
  5. XM_017021090.1XP_016876579.1  tubulinyl-Tyr carboxypeptidase 1 isoform X1

    Conserved Domains (1) summary
    pfam14822
    Location:1149
    Vasohibin

RNA

  1. XR_001750190.1 RNA Sequence

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