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VASH1 vasohibin 1 [ Homo sapiens (human) ]

Gene ID: 22846, updated on 22-Sep-2022

Summary

Official Symbol
VASH1provided by HGNC
Official Full Name
vasohibin 1provided by HGNC
Primary source
HGNC:HGNC:19964
See related
Ensembl:ENSG00000071246 MIM:609011; AllianceGenome:HGNC:19964
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TTCP 1; KIAA1036
Summary
Enables actin binding activity and metallocarboxypeptidase activity. Involved in negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; and proteolysis. Acts upstream of or within several processes, including negative regulation of endothelial cell migration; negative regulation of endothelial cell proliferation; and negative regulation of lymphangiogenesis. Located in apical part of cell; endoplasmic reticulum; and extracellular space. Implicated in liver cirrhosis and portal hypertension. Biomarker of liver cirrhosis. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 12.0), placenta (RPKM 11.8) and 25 other tissues See more
Orthologs
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Genomic context

See VASH1 in Genome Data Viewer
Location:
14q24.3
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (76761468..76783015)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (70970762..70992327)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (77227811..77249358)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene H1.8 linker histone pseudogene Neighboring gene uncharacterized LOC105370577 Neighboring gene VASH1 antisense RNA 1 Neighboring gene angel homolog 1 Neighboring gene leucine rich repeat containing 74A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metallocarboxypeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metallocarboxypeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tubulin-tyrosine carboxypeptidase IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tubulinyl-Tyr carboxypeptidase 1
Names
tubulin carboxypeptidase 1
tyrosine carboxypeptidase 1
NP_055724.1
XP_016876576.1
XP_016876580.1
XP_047287037.1
XP_047287038.1
XP_047287039.1
XP_047287040.1
XP_047287041.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014909.5NP_055724.1  tubulinyl-Tyr carboxypeptidase 1

    See identical proteins and their annotated locations for NP_055724.1

    Status: VALIDATED

    Source sequence(s)
    AB028959, AC007376, AL832588, BC051896, BE674799, BF741850
    Consensus CDS
    CCDS9851.1
    UniProtKB/Swiss-Prot
    Q7L8A9, Q9Y629
    Related
    ENSP00000167106.4, ENST00000167106.9
    Conserved Domains (1) summary
    pfam14822
    Location:58302
    Vasohibin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    76761468..76783015
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431082.1XP_047287038.1  tubulinyl-Tyr carboxypeptidase 1 isoform X1

  2. XM_047431084.1XP_047287040.1  tubulinyl-Tyr carboxypeptidase 1 isoform X1

  3. XM_047431083.1XP_047287039.1  tubulinyl-Tyr carboxypeptidase 1 isoform X1

  4. XM_047431085.1XP_047287041.1  tubulinyl-Tyr carboxypeptidase 1 isoform X1

  5. XM_017021087.2XP_016876576.1  tubulinyl-Tyr carboxypeptidase 1 isoform X1

    Conserved Domains (1) summary
    pfam14822
    Location:1149
    Vasohibin
  6. XM_047431081.1XP_047287037.1  tubulinyl-Tyr carboxypeptidase 1 isoform X1

  7. XM_017021091.2XP_016876580.1  tubulinyl-Tyr carboxypeptidase 1 isoform X2

    Conserved Domains (1) summary
    pfam14822
    Location:1120
    Vasohibin

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    70970762..70992327
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)