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Kif18a kinesin family member 18A [ Mus musculus (house mouse) ]

Gene ID: 228421, updated on 18-Apr-2024

Summary

Official Symbol
Kif18aprovided by MGI
Official Full Name
kinesin family member 18Aprovided by MGI
Primary source
MGI:MGI:2446977
See related
Ensembl:ENSMUSG00000027115 AllianceGenome:MGI:2446977
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
gcd2; B130001M12Rik
Summary
Predicted to enable several functions, including ATP hydrolysis activity; cytoskeletal protein binding activity; and plus-end-directed microtubule motor activity. Acts upstream of or within nuclear division; regulation of microtubule cytoskeleton organization; and seminiferous tubule development. Located in kinetochore and mitotic spindle midzone. Is expressed in central nervous system; gonad; and retina. Orthologous to human KIF18A (kinesin family member 18A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14 (RPKM 8.8), CNS E11.5 (RPKM 7.2) and 10 other tissues See more
Orthologs
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Genomic context

Location:
2 E3; 2 56.55 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (109111165..109172094)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (109280738..109341749)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05346 Neighboring gene predicted gene 13923 Neighboring gene methyltransferase like 15 Neighboring gene STARR-seq mESC enhancer starr_05347 Neighboring gene STARR-seq mESC enhancer starr_05348 Neighboring gene STARR-seq mESC enhancer starr_05349 Neighboring gene STARR-positive B cell enhancer ABC_E5956 Neighboring gene STARR-seq mESC enhancer starr_05353 Neighboring gene STARR-seq mESC enhancer starr_05354 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-seq mESC enhancer starr_05355 Neighboring gene brain-derived neurotrophic factor antisense RNA Neighboring gene brain derived neurotrophic factor

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC27627

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
 
enables microtubule plus-end binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables plus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables plus-end-directed microtubule motor activity ISO
Inferred from Sequence Orthology
more info
 
enables tubulin-dependent ATPase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in caveola ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in kinetochore microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitotic spindle astral microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in mitotic spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitotic spindle midzone IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
kinesin-like protein KIF18A
Names
N-8 kinesin
kinesin superfamily protein 18A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418960.1NP_001405889.1  kinesin-like protein KIF18A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL691430
  2. NM_001418961.1NP_001405890.1  kinesin-like protein KIF18A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL691430
    UniProtKB/TrEMBL
    Q8BZ45
    Related
    ENSMUST00000144924.8
  3. NM_001418962.1NP_001405891.1  kinesin-like protein KIF18A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL691430
    UniProtKB/TrEMBL
    Q8BY99
    Related
    ENSMUST00000151395.8
  4. NM_001418963.1NP_001405892.1  kinesin-like protein KIF18A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL691430
  5. NM_139303.2NP_647464.1  kinesin-like protein KIF18A isoform 1

    See identical proteins and their annotated locations for NP_647464.1

    Status: VALIDATED

    Source sequence(s)
    AL691430
    Consensus CDS
    CCDS16507.1
    UniProtKB/Swiss-Prot
    Q3TP77, Q8BLL1, Q91WD7
    Related
    ENSMUSP00000028527.8, ENSMUST00000028527.8
    Conserved Domains (2) summary
    cd01370
    Location:11355
    KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup
    pfam00225
    Location:17355
    Kinesin; Kinesin motor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    109111165..109172094
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)