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Cstf3 cleavage stimulation factor, 3' pre-RNA, subunit 3 [ Mus musculus (house mouse) ]

Gene ID: 228410, updated on 27-Nov-2024

Summary

Official Symbol
Cstf3provided by MGI
Official Full Name
cleavage stimulation factor, 3' pre-RNA, subunit 3provided by MGI
Primary source
MGI:MGI:1351825
See related
Ensembl:ENSMUSG00000027176 AllianceGenome:MGI:1351825
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CstF-77; 4732468G05Rik
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway. Predicted to be located in nucleoplasm. Predicted to be part of mRNA cleavage stimulating factor complex. Predicted to be active in nucleus. Is expressed in several structures, including ganglia; liver; submandibular gland primordium; thymus primordium; and vibrissa. Orthologous to human CSTF3 (cleavage stimulation factor subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 8.3), CNS E14 (RPKM 7.4) and 24 other tissues See more
Orthologs
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Genomic context

See Cstf3 in Genome Data Viewer
Location:
2 E2; 2 54.84 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (104420829..104495770)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (104590484..104665425)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9199 Neighboring gene pluripotency associated transcript 14 Neighboring gene predicted gene, 22439 Neighboring gene STARR-positive B cell enhancer ABC_E2044 Neighboring gene t-complex 11 like 1 Neighboring gene predicted gene 6306 Neighboring gene peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1, retrogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC6373

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of mRNA cleavage stimulating factor complex IEA
Inferred from Electronic Annotation
more info
 
part_of mRNA cleavage stimulating factor complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
cleavage stimulation factor subunit 3
Names
CF-1 77 kDa subunit
CSTF 77 kDa subunit
cleavage stimulation factor 77 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037326.2NP_001032403.1  cleavage stimulation factor subunit 3 isoform 3

    See identical proteins and their annotated locations for NP_001032403.1

    Status: VALIDATED

    Source sequence(s)
    AL844603
    Related
    ENSMUST00000137961.2
  2. NM_145529.3NP_663504.1  cleavage stimulation factor subunit 3 isoform 1

    See identical proteins and their annotated locations for NP_663504.1

    Status: VALIDATED

    Source sequence(s)
    AL844603
    Consensus CDS
    CCDS16490.1
    UniProtKB/Swiss-Prot
    Q99LI7
    UniProtKB/TrEMBL
    Q3TXN6
    Related
    ENSMUSP00000028599.8, ENSMUST00000028599.8
    Conserved Domains (3) summary
    COG5107
    Location:2532
    RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]
    sd00006
    Location:3160
    TPR; TPR repeat [structural motif]
    pfam05843
    Location:375649
    Suf; Suppressor of forked protein (Suf)
  3. NM_177253.4NP_796227.1  cleavage stimulation factor subunit 3 isoform 2

    See identical proteins and their annotated locations for NP_796227.1

    Status: VALIDATED

    Source sequence(s)
    AL844603
    UniProtKB/TrEMBL
    Q8CE71
    Related
    ENSMUST00000122900.2
    Conserved Domains (2) summary
    smart00386
    Location:4577
    HAT; HAT (Half-A-TPR) repeats
    cl19115
    Location:6394
    Cupredoxin; Cupredoxin superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    104420829..104495770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)