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RAB11FIP2 RAB11 family interacting protein 2 [ Homo sapiens (human) ]

Gene ID: 22841, updated on 1-Mar-2024

Summary

Official Symbol
RAB11FIP2provided by HGNC
Official Full Name
RAB11 family interacting protein 2provided by HGNC
Primary source
HGNC:HGNC:29152
See related
Ensembl:ENSG00000107560 MIM:608599; AllianceGenome:HGNC:29152
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
nRip11; Rab11-FIP2
Summary
Enables protein homodimerization activity and protein kinase binding activity. Involved in several processes, including TRAM-dependent toll-like receptor 4 signaling pathway; phagocytosis; and positive regulation of GTPase activity. Located in endosome; nucleoplasm; and phagocytic cup. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in endometrium (RPKM 12.0), brain (RPKM 9.2) and 25 other tissues See more
Orthologs
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Genomic context

See RAB11FIP2 in Genome Data Viewer
Location:
10q26.11
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (118004916..118046941, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (118898958..118940990, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (119764427..119806452, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2674 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:119545298-119545468 Neighboring gene VISTA enhancer hs1236 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:119597764-119598550 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:119658461-119659162 Neighboring gene uncharacterized LOC105378504 Neighboring gene VISTA enhancer hs1551 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:119739304-119740503 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:119795138-119795331 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2863 Neighboring gene cancer susceptibility 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:119907111-119907355 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:119963650-119964234 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:119964235-119964819 Neighboring gene Sharpr-MPRA regulatory region 3281 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:119973305-119974504 Neighboring gene long intergenic non-protein coding RNA 2944 Neighboring gene NANOG hESC enhancer GRCh37_chr10:120025545-120026208 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:120044911-120045412 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:120045413-120045912 Neighboring gene VISTA enhancer hs672 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:120101641-120102140 Neighboring gene family with sequence similarity 204 member A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease.
EBI GWAS Catalog
Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits.
EBI GWAS Catalog
Genome-wide interaction studies reveal sex-specific asthma risk alleles.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0941

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in TRAM-dependent toll-like receptor 4 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in insulin secretion involved in cellular response to glucose stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in regulated exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulated exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle membrane TAS
Traceable Author Statement
more info
 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in phagocytic cup IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in phagocytic cup IDA
Inferred from Direct Assay
more info
PubMed 
located_in recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
rab11 family-interacting protein 2
Names
RAB11 family interacting protein 2 (class I)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330167.2NP_001317096.1  rab11 family-interacting protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC022395, DQ013303, R52658
    Consensus CDS
    CCDS81512.1
    UniProtKB/Swiss-Prot
    Q7L804
    Related
    ENSP00000358200.3, ENST00000369199.5
    Conserved Domains (2) summary
    cd08682
    Location:15141
    C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
    pfam09457
    Location:472519
    RBD-FIP; FIP domain
  2. NM_014904.3NP_055719.1  rab11 family-interacting protein 2 isoform 1

    See identical proteins and their annotated locations for NP_055719.1

    Status: VALIDATED

    Source sequence(s)
    AB023158, AC022395, BM975322
    Consensus CDS
    CCDS7602.1
    UniProtKB/Swiss-Prot
    A6NEI4, Q3I768, Q7L804, Q9Y2F0
    Related
    ENSP00000347839.3, ENST00000355624.8
    Conserved Domains (2) summary
    cd08682
    Location:15141
    C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
    pfam09457
    Location:452499
    RBD-FIP; FIP domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    118004916..118046941 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    118898958..118940990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)