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RNF44 ring finger protein 44 [ Homo sapiens (human) ]

Gene ID: 22838, updated on 24-Nov-2020

Summary

Official Symbol
RNF44provided by HGNC
Official Full Name
ring finger protein 44provided by HGNC
Primary source
HGNC:HGNC:19180
See related
Ensembl:ENSG00000146083
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in spleen (RPKM 19.0), lymph node (RPKM 14.6) and 25 other tissues See more
Orthologs

Genomic context

See RNF44 in Genome Data Viewer
Location:
5q35.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (176526704..176544206, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (175953700..175965026, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ADP ribosylation factor like GTPase 10 Neighboring gene clathrin light chain B Neighboring gene Fas associated factor family member 2 Neighboring gene collagen alpha-1(III) chain-like Neighboring gene RNA, 7SL, cytoplasmic 684, pseudogene Neighboring gene cadherin related family member 2 Neighboring gene G protein regulated inducer of neurite outgrowth 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1100

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014901.5NP_055716.1  RING finger protein 44

    See identical proteins and their annotated locations for NP_055716.1

    Status: REVIEWED

    Source sequence(s)
    BC039833, BC063297
    Consensus CDS
    CCDS4404.1
    UniProtKB/Swiss-Prot
    Q7L0R7
    UniProtKB/TrEMBL
    A0A024R7Q1
    Related
    ENSP00000274811.4, ENST00000274811.9
    Conserved Domains (1) summary
    cd16472
    Location:377421
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    176526704..176544206 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534466.3XP_011532768.1  RING finger protein 44 isoform X1

    See identical proteins and their annotated locations for XP_011532768.1

    UniProtKB/Swiss-Prot
    Q7L0R7
    UniProtKB/TrEMBL
    A0A024R7Q1
    Conserved Domains (1) summary
    cd16472
    Location:377421
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  2. XM_005265844.3XP_005265901.1  RING finger protein 44 isoform X4

    See identical proteins and their annotated locations for XP_005265901.1

    UniProtKB/Swiss-Prot
    Q7L0R7
    Conserved Domains (1) summary
    cd16472
    Location:296340
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  3. XM_005265842.5XP_005265899.1  RING finger protein 44 isoform X4

    See identical proteins and their annotated locations for XP_005265899.1

    UniProtKB/Swiss-Prot
    Q7L0R7
    Conserved Domains (1) summary
    cd16472
    Location:296340
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  4. XM_011534467.2XP_011532769.1  RING finger protein 44 isoform X4

    See identical proteins and their annotated locations for XP_011532769.1

    UniProtKB/Swiss-Prot
    Q7L0R7
    Conserved Domains (1) summary
    cd16472
    Location:296340
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  5. XM_005265841.4XP_005265898.1  RING finger protein 44 isoform X1

    See identical proteins and their annotated locations for XP_005265898.1

    UniProtKB/Swiss-Prot
    Q7L0R7
    UniProtKB/TrEMBL
    A0A024R7Q1
    Conserved Domains (1) summary
    cd16472
    Location:377421
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  6. XM_005265845.4XP_005265902.1  RING finger protein 44 isoform X4

    See identical proteins and their annotated locations for XP_005265902.1

    UniProtKB/Swiss-Prot
    Q7L0R7
    Conserved Domains (1) summary
    cd16472
    Location:296340
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  7. XM_005265843.2XP_005265900.1  RING finger protein 44 isoform X4

    See identical proteins and their annotated locations for XP_005265900.1

    UniProtKB/Swiss-Prot
    Q7L0R7
    Conserved Domains (1) summary
    cd16472
    Location:296340
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  8. XM_006714832.2XP_006714895.1  RING finger protein 44 isoform X3

    Conserved Domains (1) summary
    pfam13639
    Location:333374
    zf-RING_2; Ring finger domain
  9. XM_006714831.2XP_006714894.1  RING finger protein 44 isoform X2

    Conserved Domains (1) summary
    cd16472
    Location:374418
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  10. XM_005265840.2XP_005265897.1  RING finger protein 44 isoform X1

    See identical proteins and their annotated locations for XP_005265897.1

    UniProtKB/Swiss-Prot
    Q7L0R7
    UniProtKB/TrEMBL
    A0A024R7Q1
    Conserved Domains (1) summary
    cd16472
    Location:377421
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  11. XM_024446002.1XP_024301770.1  RING finger protein 44 isoform X5

    Conserved Domains (1) summary
    cd16472
    Location:249293
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

RNA

  1. XR_941091.2 RNA Sequence

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