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RNF44 ring finger protein 44 [ Homo sapiens (human) ]

Gene ID: 22838, updated on 12-Aug-2022

Summary

Official Symbol
RNF44provided by HGNC
Official Full Name
ring finger protein 44provided by HGNC
Primary source
HGNC:HGNC:19180
See related
Ensembl:ENSG00000146083 MIM:619283; AllianceGenome:HGNC:19180
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in spleen (RPKM 19.0), lymph node (RPKM 14.6) and 25 other tissues See more
Orthologs
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Genomic context

See RNF44 in Genome Data Viewer
Location:
5q35.2
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (176526712..176543513, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (177071267..177081965, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (175953713..175964403, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ADP ribosylation factor like GTPase 10 Neighboring gene clathrin light chain B Neighboring gene uncharacterized LOC124901142 Neighboring gene Fas associated factor family member 2 Neighboring gene uncharacterized LOC124901143 Neighboring gene RNA, 7SL, cytoplasmic 684, pseudogene Neighboring gene cadherin related family member 2 Neighboring gene Sharpr-MPRA regulatory region 7457

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1100

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014901.5NP_055716.1  RING finger protein 44

    See identical proteins and their annotated locations for NP_055716.1

    Status: REVIEWED

    Source sequence(s)
    BC039833, BC063297
    Consensus CDS
    CCDS4404.1
    UniProtKB/Swiss-Prot
    Q7L0R7, Q9UPQ2
    UniProtKB/TrEMBL
    A0A024R7Q1
    Related
    ENSP00000274811.4, ENST00000274811.9
    Conserved Domains (1) summary
    cd16472
    Location:377421
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    176526712..176543513 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047416956.1XP_047272912.1  RING finger protein 44 isoform X4

  2. XM_047416952.1XP_047272908.1  RING finger protein 44 isoform X2

  3. XM_047416949.1XP_047272905.1  RING finger protein 44 isoform X1

    UniProtKB/Swiss-Prot
    Q9UPQ2
    UniProtKB/TrEMBL
    A0A024R7Q1
  4. XM_011534466.4XP_011532768.1  RING finger protein 44 isoform X1

    See identical proteins and their annotated locations for XP_011532768.1

    UniProtKB/Swiss-Prot
    Q7L0R7, Q9UPQ2
    UniProtKB/TrEMBL
    A0A024R7Q1
    Conserved Domains (1) summary
    cd16472
    Location:377421
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  5. XM_047416957.1XP_047272913.1  RING finger protein 44 isoform X5

  6. XM_006714832.3XP_006714895.1  RING finger protein 44 isoform X4

    Conserved Domains (1) summary
    pfam13639
    Location:333374
    zf-RING_2; Ring finger domain
  7. XM_006714831.3XP_006714894.1  RING finger protein 44 isoform X2

    Conserved Domains (1) summary
    cd16472
    Location:374418
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  8. XM_005265840.3XP_005265897.1  RING finger protein 44 isoform X1

    See identical proteins and their annotated locations for XP_005265897.1

    UniProtKB/Swiss-Prot
    Q7L0R7, Q9UPQ2
    UniProtKB/TrEMBL
    A0A024R7Q1
    Conserved Domains (1) summary
    cd16472
    Location:377421
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  9. XM_047416958.1XP_047272914.1  RING finger protein 44 isoform X5

  10. XM_047416954.1XP_047272910.1  RING finger protein 44 isoform X4

  11. XM_047416950.1XP_047272906.1  RING finger protein 44 isoform X2

  12. XM_047416955.1XP_047272911.1  RING finger protein 44 isoform X4

  13. XM_047416951.1XP_047272907.1  RING finger protein 44 isoform X2

  14. XM_005265841.5XP_005265898.1  RING finger protein 44 isoform X1

    See identical proteins and their annotated locations for XP_005265898.1

    UniProtKB/Swiss-Prot
    Q7L0R7, Q9UPQ2
    UniProtKB/TrEMBL
    A0A024R7Q1
    Conserved Domains (1) summary
    cd16472
    Location:377421
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  15. XM_005265844.4XP_005265901.1  RING finger protein 44 isoform X6

    See identical proteins and their annotated locations for XP_005265901.1

    UniProtKB/Swiss-Prot
    Q7L0R7
    Conserved Domains (1) summary
    cd16472
    Location:296340
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  16. XM_005265843.3XP_005265900.1  RING finger protein 44 isoform X6

    See identical proteins and their annotated locations for XP_005265900.1

    UniProtKB/Swiss-Prot
    Q7L0R7
    Conserved Domains (1) summary
    cd16472
    Location:296340
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  17. XM_047416953.1XP_047272909.1  RING finger protein 44 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    177071267..177081965 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)