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RHOBTB3 Rho related BTB domain containing 3 [ Homo sapiens (human) ]

Gene ID: 22836, updated on 12-Oct-2019

Summary

Official Symbol
RHOBTB3provided by HGNC
Official Full Name
Rho related BTB domain containing 3provided by HGNC
Primary source
HGNC:HGNC:18757
See related
Ensembl:ENSG00000164292 MIM:607353
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
RHOBTB3 is a member of the evolutionarily conserved RHOBTB subfamily of Rho GTPases. For background information on RHOBTBs, see RHOBTB1 (MIM 607351).[supplied by OMIM, Apr 2004]
Expression
Ubiquitous expression in fat (RPKM 37.7), ovary (RPKM 32.7) and 24 other tissues See more
Orthologs

Genomic context

See RHOBTB3 in Genome Data Viewer
Location:
5q15
Exon count:
14
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (95713522..95796361)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (95049181..95132071)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Rieske Fe-S domain containing Neighboring gene uncharacterized LOC105379090 Neighboring gene spermatogenesis associated 9 Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 11 Neighboring gene gamma-glutamylcyclotransferase pseudogene Neighboring gene glutaredoxin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
    Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Retrograde transport at the Trans-Golgi-Network, organism-specific biosystem (from REACTOME)
    Retrograde transport at the Trans-Golgi-Network, organism-specific biosystemThe trans-Golgi network is the docking site for retrograde cargo from the endolysosomal system and the plasma membrane. Typical cargo includes recycling resident TGN proteins such as TGOLN2 (also kn...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0878

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
ATPase activity TAS
Traceable Author Statement
more info
 
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rab GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
engulfment of apoptotic cell IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
male gonad development IEA
Inferred from Electronic Annotation
more info
 
motor neuron axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retrograde transport, endosome to Golgi IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
trans-Golgi network membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
rho-related BTB domain-containing protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014899.4NP_055714.3  rho-related BTB domain-containing protein 3

    See identical proteins and their annotated locations for NP_055714.3

    Status: VALIDATED

    Source sequence(s)
    AB020685, AC008821, BC020231, CN361948
    Consensus CDS
    CCDS4077.1
    UniProtKB/Swiss-Prot
    O94955
    Related
    ENSP00000369318.3, ENST00000379982.8
    Conserved Domains (3) summary
    smart00225
    Location:421518
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00651
    Location:413515
    BTB; BTB/POZ domain
    cl21455
    Location:34174
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    95713522..95796361
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009237.1XP_016864726.1  rho-related BTB domain-containing protein 3 isoform X2

  2. XM_017009236.1XP_016864725.1  rho-related BTB domain-containing protein 3 isoform X2

  3. XM_011543279.2XP_011541581.1  rho-related BTB domain-containing protein 3 isoform X1

    Conserved Domains (3) summary
    smart00225
    Location:299396
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00651
    Location:291393
    BTB; BTB/POZ domain
    cl21455
    Location:34174
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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