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Arhgap1 Rho GTPase activating protein 1 [ Mus musculus (house mouse) ]

Gene ID: 228359, updated on 12-May-2024

Summary

Official Symbol
Arhgap1provided by MGI
Official Full Name
Rho GTPase activating protein 1provided by MGI
Primary source
MGI:MGI:2445003
See related
Ensembl:ENSMUSG00000027247 AllianceGenome:MGI:2445003
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cdc42GAP; p50rhoGAP; B230365D05Rik
Summary
Enables GTPase activator activity. Acts upstream of or within regulation of GTPase activity. Located in plasma membrane and ruffle. Orthologous to human ARHGAP1 (Rho GTPase activating protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 49.0), lung adult (RPKM 47.5) and 28 other tissues See more
Orthologs
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Genomic context

See Arhgap1 in Genome Data Viewer
Location:
2 E1; 2 50.63 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (91480463..91502670)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (91650118..91672325)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:91486007-91486292 Neighboring gene cytochrome c oxidase subunit 7B, mitochondrial pseudogene Neighboring gene zinc finger protein 408 Neighboring gene STARR-positive B cell enhancer ABC_E1007 Neighboring gene autophagy related 13 Neighboring gene STARR-seq mESC enhancer starr_05121 Neighboring gene harbinger transposase derived 1 Neighboring gene dyskeratosis congenita 1, dyskerin homolog pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC7050, MGC101942

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in endosomal transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of endocytic recycling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in small GTPase-mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within small GTPase-mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in transferrin transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in ruffle IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with sorting endosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
rho GTPase-activating protein 1
Names
rho-type GTPase-activating protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145902.1NP_001139374.1  rho GTPase-activating protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK046291, AL691489, BC089306
    Consensus CDS
    CCDS50641.1
    UniProtKB/TrEMBL
    A2AH25, Q8BQW4
    Related
    ENSMUSP00000106963.3, ENSMUST00000111331.9
    Conserved Domains (2) summary
    cd04404
    Location:279471
    RhoGAP-p50rhoGAP; RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol ...
    pfam13716
    Location:122246
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  2. NM_001359970.1NP_001346899.1  rho GTPase-activating protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' structure, resulting in a novel 5' UTR and the use of a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 6 encode the same isoform.
    Source sequence(s)
    AL691489, AL714023
    Consensus CDS
    CCDS16437.1
    UniProtKB/Swiss-Prot
    Q5FWK3, Q8C3X5, Q923D8
    UniProtKB/TrEMBL
    A0A2X0SSA9
    Related
    ENSMUSP00000088105.5, ENSMUST00000090614.11
    Conserved Domains (2) summary
    cd04404
    Location:239431
    RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
    pfam13716
    Location:82216
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  3. NM_146124.4NP_666236.3  rho GTPase-activating protein 1 isoform 2

    See identical proteins and their annotated locations for NP_666236.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' structure, resulting in a novel 5' UTR and the use of a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 6 encode the same isoform.
    Source sequence(s)
    AK084622, BC089306
    Consensus CDS
    CCDS16437.1
    UniProtKB/Swiss-Prot
    Q5FWK3, Q8C3X5, Q923D8
    UniProtKB/TrEMBL
    A0A2X0SSA9
    Related
    ENSMUSP00000106962.3, ENSMUST00000111330.3
    Conserved Domains (2) summary
    cd04404
    Location:239431
    RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
    pfam13716
    Location:82216
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

RNA

  1. NR_027371.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon compared to variant 1. This exon disrupts the reading frame of the protein and makes this transcript a candidate for nonsense-mediated mRNA decay. This variant is not thought to encode a protein.
    Source sequence(s)
    AK046291, AK085554, BC089306, BY294066
  2. NR_027372.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon compared to variant 1. This exon disrupts the reading frame of the protein and makes this transcript a candidate for nonsense-mediated mRNA decay. This variant is not thought to encode a protein.
    Source sequence(s)
    AK046291, AK079048, BC089306, BY294066
  3. NR_027373.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate exon and alternate splice junction compared to variant 1. These differences disrupt the reading frame of the protein and make this transcript a candidate for nonsense-mediated mRNA decay. This variant is not thought to encode a protein.
    Source sequence(s)
    AK046291, BC089306, BQ571397, BY294066

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    91480463..91502670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499251.2XP_006499314.1  rho GTPase-activating protein 1 isoform X2

    UniProtKB/TrEMBL
    Q8C5A0
    Conserved Domains (2) summary
    cd04404
    Location:202394
    RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
    pfam13716
    Location:45179
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  2. XM_006499249.3XP_006499312.1  rho GTPase-activating protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006499312.1

    UniProtKB/Swiss-Prot
    Q5FWK3, Q8C3X5, Q923D8
    UniProtKB/TrEMBL
    A0A2X0SSA9
    Conserved Domains (2) summary
    cd04404
    Location:239431
    RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
    pfam13716
    Location:82216
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  3. XM_006499248.4XP_006499311.1  rho GTPase-activating protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006499311.1

    UniProtKB/Swiss-Prot
    Q5FWK3, Q8C3X5, Q923D8
    UniProtKB/TrEMBL
    A0A2X0SSA9
    Conserved Domains (2) summary
    cd04404
    Location:239431
    RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
    pfam13716
    Location:82216
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  4. XM_006499244.2XP_006499307.1  rho GTPase-activating protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006499307.1

    UniProtKB/Swiss-Prot
    Q5FWK3, Q8C3X5, Q923D8
    UniProtKB/TrEMBL
    A0A2X0SSA9
    Conserved Domains (2) summary
    cd04404
    Location:239431
    RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
    pfam13716
    Location:82216
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  5. XM_006499245.5XP_006499308.1  rho GTPase-activating protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006499308.1

    UniProtKB/Swiss-Prot
    Q5FWK3, Q8C3X5, Q923D8
    UniProtKB/TrEMBL
    A0A2X0SSA9
    Conserved Domains (2) summary
    cd04404
    Location:239431
    RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
    pfam13716
    Location:82216
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  6. XM_006499250.2XP_006499313.1  rho GTPase-activating protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006499313.1

    UniProtKB/Swiss-Prot
    Q5FWK3, Q8C3X5, Q923D8
    UniProtKB/TrEMBL
    A0A2X0SSA9
    Conserved Domains (2) summary
    cd04404
    Location:239431
    RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
    pfam13716
    Location:82216
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  7. XM_011239457.2XP_011237759.1  rho GTPase-activating protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011237759.1

    UniProtKB/Swiss-Prot
    Q5FWK3, Q8C3X5, Q923D8
    UniProtKB/TrEMBL
    A0A2X0SSA9
    Conserved Domains (2) summary
    cd04404
    Location:239431
    RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
    pfam13716
    Location:82216
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  8. XM_006499247.4XP_006499310.1  rho GTPase-activating protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006499310.1

    UniProtKB/Swiss-Prot
    Q5FWK3, Q8C3X5, Q923D8
    UniProtKB/TrEMBL
    A0A2X0SSA9
    Conserved Domains (2) summary
    cd04404
    Location:239431
    RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
    pfam13716
    Location:82216
    CRAL_TRIO_2; Divergent CRAL/TRIO domain