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ZFP30 ZFP30 zinc finger protein [ Homo sapiens (human) ]

Gene ID: 22835, updated on 17-Sep-2024

Summary

Official Symbol
ZFP30provided by HGNC
Official Full Name
ZFP30 zinc finger proteinprovided by HGNC
Primary source
HGNC:HGNC:29555
See related
Ensembl:ENSG00000120784 MIM:617317; AllianceGenome:HGNC:29555
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF745
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 2.7), thyroid (RPKM 2.4) and 25 other tissues See more
Orthologs
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Genomic context

See ZFP30 in Genome Data Viewer
Location:
19q13.12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (37631006..37656261, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (40432744..40458006, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (38121907..38147162, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF571 antisense RNA 1 Neighboring gene zinc finger protein 540 Neighboring gene zinc finger protein 571 Neighboring gene MT-ND5 pseudogene 45 Neighboring gene MT-CO1 pseudogene 41 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38084654-38085335 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38085336-38086018 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14554 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10556 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38146535-38147522 Neighboring gene zinc finger protein 781 Neighboring gene selenoprotein K pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0961

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
zinc finger protein 30 homolog
Names
zinc finger protein 745

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054886.1 RefSeqGene

    Range
    6821..31280
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001320666.3NP_001307595.1  zinc finger protein 30 homolog isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein (isoform 1).
    Source sequence(s)
    AB023178, AC022148, AC093227, AI377404, BC041087, GU388430
    Consensus CDS
    CCDS33005.1
    UniProtKB/Swiss-Prot
    Q58EY8, Q9Y2G7
    UniProtKB/TrEMBL
    D3Y2A0
    Conserved Domains (3) summary
    smart00349
    Location:667
    KRAB; krueppel associated box
    COG5048
    Location:156509
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:440460
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001320667.3NP_001307596.1  zinc finger protein 30 homolog isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein (isoform 1).
    Source sequence(s)
    AC022148, AC093227, AI377404, BC050542, GU388430
    Consensus CDS
    CCDS33005.1
    UniProtKB/Swiss-Prot
    Q58EY8, Q9Y2G7
    UniProtKB/TrEMBL
    D3Y2A0
    Conserved Domains (3) summary
    smart00349
    Location:667
    KRAB; krueppel associated box
    COG5048
    Location:156509
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:440460
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001320668.3NP_001307597.1  zinc finger protein 30 homolog isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 - 5 encode the same protein (isoform 1).
    Source sequence(s)
    AC022148, AI377404, GU388430
    Consensus CDS
    CCDS33005.1
    UniProtKB/Swiss-Prot
    Q58EY8, Q9Y2G7
    UniProtKB/TrEMBL
    D3Y2A0
    Related
    ENSP00000422930.2, ENST00000514101.6
    Conserved Domains (3) summary
    smart00349
    Location:667
    KRAB; krueppel associated box
    COG5048
    Location:156509
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:440460
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_001320669.3NP_001307598.1  zinc finger protein 30 homolog isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein (isoform 1).
    Source sequence(s)
    AC022148, AC093227, AI377404, GU388430
    Consensus CDS
    CCDS33005.1
    UniProtKB/Swiss-Prot
    Q58EY8, Q9Y2G7
    UniProtKB/TrEMBL
    D3Y2A0
    Related
    ENSP00000508019.1, ENST00000684514.1
    Conserved Domains (3) summary
    smart00349
    Location:667
    KRAB; krueppel associated box
    COG5048
    Location:156509
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:440460
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. NM_001320670.3NP_001307599.1  zinc finger protein 30 homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1. Variants 6 and 7 encode the same protein (isoform 2).
    Source sequence(s)
    AC022148, AI377404, DA802473, GU388430
    Conserved Domains (3) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:155508
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:439459
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. NM_001320671.3NP_001307600.1  zinc finger protein 30 homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1. Variants 6 and 7 encode the same protein (isoform 2).
    Source sequence(s)
    AC022148, AC093227, AI377404, AK297301, GU388430
    Conserved Domains (3) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:155508
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:439459
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. NM_014898.4NP_055713.1  zinc finger protein 30 homolog isoform 1

    See identical proteins and their annotated locations for NP_055713.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1-5 encode the same protein (isoform 1).
    Source sequence(s)
    AB023178, AC022148, AC093227, AI377404
    Consensus CDS
    CCDS33005.1
    UniProtKB/Swiss-Prot
    Q58EY8, Q9Y2G7
    UniProtKB/TrEMBL
    D3Y2A0
    Related
    ENSP00000343581.1, ENST00000351218.6
    Conserved Domains (3) summary
    smart00349
    Location:667
    KRAB; krueppel associated box
    COG5048
    Location:156509
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:440460
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    37631006..37656261 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    40432744..40458006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)