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ZNF652 zinc finger protein 652 [ Homo sapiens (human) ]

Gene ID: 22834, updated on 11-Jun-2021

Summary

Official Symbol
ZNF652provided by HGNC
Official Full Name
zinc finger protein 652provided by HGNC
Primary source
HGNC:HGNC:29147
See related
Ensembl:ENSG00000198740 MIM:613907
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in skin (RPKM 5.2), testis (RPKM 3.9) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF652 in Genome Data Viewer
Location:
17q21.32-q21.33
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (49289206..49362473, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (47366568..47439835, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized FLJ40194 Neighboring gene microRNA 6129 Neighboring gene ZNF652 antisense RNA 1 Neighboring gene ribosomal protein L21 pseudogene 124 Neighboring gene prohibitin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
GeneReviews: Not available
Genome-wide association study identifies eight loci associated with blood pressure.
GeneReviews: Not available
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
GeneReviews: Not available
Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21.
GeneReviews: Not available
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
GeneReviews: Not available
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0924, DKFZp781E2122

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145365.3NP_001138837.1  zinc finger protein 652

    See identical proteins and their annotated locations for NP_001138837.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC004797, AC091180, AK292667, BC152440, DN998934
    Consensus CDS
    CCDS32677.1
    UniProtKB/Swiss-Prot
    Q9Y2D9
    UniProtKB/TrEMBL
    A8K9F2
    Related
    ENSP00000416305.2, ENST00000430262.3
    Conserved Domains (4) summary
    COG5048
    Location:439488
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:381464
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:387407
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl27293
    Location:240304
    UFD1; Ubiquitin fusion degradation protein UFD1
  2. NM_014897.2NP_055712.1  zinc finger protein 652

    See identical proteins and their annotated locations for NP_055712.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC004797, BC152440
    Consensus CDS
    CCDS32677.1
    UniProtKB/Swiss-Prot
    Q9Y2D9
    Related
    ENSP00000354686.2, ENST00000362063.6
    Conserved Domains (4) summary
    COG5048
    Location:439488
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:381464
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:387407
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl27293
    Location:240304
    UFD1; Ubiquitin fusion degradation protein UFD1

RNA

  1. NR_135579.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC091180, BC034987, BF763222, BU838341, CN371383, DN998934

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    49289206..49362473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450656.1XP_024306424.1  zinc finger protein 652 isoform X2

    Related
    ENSP00000424848.1, ENST00000508237.5
  2. XM_024450654.1XP_024306422.1  zinc finger protein 652 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:439488
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:381464
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:387407
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl27293
    Location:240304
    UFD1; Ubiquitin fusion degradation protein UFD1
  3. XM_024450653.1XP_024306421.1  zinc finger protein 652 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:439488
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:381464
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:387407
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl27293
    Location:240304
    UFD1; Ubiquitin fusion degradation protein UFD1
  4. XM_024450655.1XP_024306423.1  zinc finger protein 652 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:439488
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:381464
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:387407
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl27293
    Location:240304
    UFD1; Ubiquitin fusion degradation protein UFD1

RNA

  1. XR_934423.2 RNA Sequence

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