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CEP162 centrosomal protein 162 [ Homo sapiens (human) ]

Gene ID: 22832, updated on 5-Jan-2022

Summary

Official Symbol
CEP162provided by HGNC
Official Full Name
centrosomal protein 162provided by HGNC
Primary source
HGNC:HGNC:21107
See related
Ensembl:ENSG00000135315 MIM:610201
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
QN1; C6orf84; KIAA1009
Summary
Involved in cilium assembly. Located in axonemal microtubule; centriole; and centrosome. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in testis (RPKM 6.2), thyroid (RPKM 2.2) and 24 other tissues See more
Orthologs
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Genomic context

See CEP162 in Genome Data Viewer
Location:
6q14.2-q14.3
Exon count:
32
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (84124250..84227889, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (84833969..84937361, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2857 Neighboring gene VISTA enhancer hs2063 Neighboring gene melanocortin 2 receptor accessory protein 2 Neighboring gene uncharacterized LOC107986621 Neighboring gene uncharacterized LOC107986620 Neighboring gene uncharacterized LOC107986619

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study for diabetic retinopathy in a Japanese population: potential association with a long intergenic non-coding RNA.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13551, KIAA1009

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in axonemal microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in axonemal microtubule IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centriole IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in spindle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
centrosomal protein of 162 kDa
Names
centrosomal protein 162kDa
protein QN1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286206.2NP_001273135.1  centrosomal protein of 162 kDa isoform b

    See identical proteins and their annotated locations for NP_001273135.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon but includes a different alternate exon in the 5' region, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AB023226, AL138742, AW069289, BC063632, CD684914
    Consensus CDS
    CCDS69149.1
    UniProtKB/Swiss-Prot
    Q5TB80
    Related
    ENSP00000257766.4, ENST00000257766.8
    Conserved Domains (1) summary
    TIGR02168
    Location:5961309
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  2. NM_014895.4NP_055710.2  centrosomal protein of 162 kDa isoform a

    See identical proteins and their annotated locations for NP_055710.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AB023226, AK308190, AL138742, AW069289, BC063632, CD684914
    Consensus CDS
    CCDS34494.2
    UniProtKB/Swiss-Prot
    Q5TB80
    Related
    ENSP00000385215.3, ENST00000403245.8
    Conserved Domains (1) summary
    TIGR02168
    Location:6721385
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    84124250..84227889 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010484.2XP_016865973.1  centrosomal protein of 162 kDa isoform X2

    UniProtKB/Swiss-Prot
    Q5TB80
    Conserved Domains (1) summary
    TIGR02168
    Location:5961309
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  2. XM_005248674.4XP_005248731.1  centrosomal protein of 162 kDa isoform X1

    See identical proteins and their annotated locations for XP_005248731.1

    Conserved Domains (1) summary
    TIGR02168
    Location:6341347
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  3. XM_006715380.3XP_006715443.1  centrosomal protein of 162 kDa isoform X2

    See identical proteins and their annotated locations for XP_006715443.1

    UniProtKB/Swiss-Prot
    Q5TB80
    Conserved Domains (1) summary
    TIGR02168
    Location:5961309
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  4. XM_017010483.2XP_016865972.1  centrosomal protein of 162 kDa isoform X1

    Conserved Domains (1) summary
    TIGR02168
    Location:6341347
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  5. XM_011535592.3XP_011533894.1  centrosomal protein of 162 kDa isoform X3

    Related
    ENST00000461137.5
    Conserved Domains (1) summary
    TIGR02168
    Location:283996
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  6. XM_011535594.2XP_011533896.1  centrosomal protein of 162 kDa isoform X4

RNA

  1. XR_942351.3 RNA Sequence

  2. XR_001743263.2 RNA Sequence

  3. XR_001743264.2 RNA Sequence

  4. XR_001743262.2 RNA Sequence

  5. XR_002956270.1 RNA Sequence

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