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HSPA4L heat shock protein family A (Hsp70) member 4 like [ Homo sapiens (human) ]

Gene ID: 22824, updated on 4-Nov-2018

Summary

Official Symbol
HSPA4Lprovided by HGNC
Official Full Name
heat shock protein family A (Hsp70) member 4 likeprovided by HGNC
Primary source
HGNC:HGNC:17041
See related
Ensembl:ENSG00000164070 Vega:OTTHUMG00000133302
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APG-1; HSPH3; Osp94
Summary
The protein encoded by this gene is heat shock inducible and may act as a chaperone. The encoded protein can protect the heat-shocked cell against the harmful effects of aggregated proteins. This gene is highly expressed in leukemia cells and may be a good target for therapeutic intervention. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Expression
Biased expression in testis (RPKM 41.4), esophagus (RPKM 5.8) and 4 other tissues See more
Orthologs

Genomic context

See HSPA4L in Genome Data Viewer
Location:
4q28.1
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (127781821..127834073)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (128703453..128755228)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377413 Neighboring gene inturned planar cell polarity protein Neighboring gene solute carrier family 25 member 31 Neighboring gene uncharacterized LOC105377414 Neighboring gene SOSS complex subunit C pseudogene Neighboring gene ribosomal protein L21 pseudogene 53 Neighboring gene RNA, U6 small nuclear 583, pseudogene Neighboring gene polo like kinase 4 Neighboring gene major facilitator superfamily domain containing 8 Neighboring gene abhydrolase domain containing 18

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Cellular response to heat stress, organism-specific biosystem (from REACTOME)
    Cellular response to heat stress, organism-specific biosystemIn response to exposure to elevated temperature and certain other proteotoxic stimuli (e.g., hypoxia, free radicals) cells activate a number of cytoprotective mechanisms known collectively as "heat s...
  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
  • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Regulation of HSF1-mediated heat shock response, organism-specific biosystem (from REACTOME)
    Regulation of HSF1-mediated heat shock response, organism-specific biosystemThe ability of HSF1 to respond to cellular stresses is under negative regulation by chaperones, modulation of nucleocytoplasmic shuttling, post-translational modifications and transition from monomer...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
protein folding ISS
Inferred from Sequence or Structural Similarity
more info
 
response to unfolded protein ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
heat shock 70 kDa protein 4L
Names
heat shock 70 kDa protein 4-like protein
heat shock 70-related protein APG-1
heat shock 70kDa protein 4-like
heat shock protein (hsp110 family)
osmotic stress protein 94
testis tissue sperm-binding protein Li 64n

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317381.1NP_001304310.1  heat shock 70 kDa protein 4L isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is longer at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC093591, AK303053, BC040560, BM679019
    UniProtKB/Swiss-Prot
    O95757
    UniProtKB/TrEMBL
    B4DZR0
    Conserved Domains (2) summary
    cd11738
    Location:33415
    HSPA4L_NBD; Nucleotide-binding domain of HSPA4L
    pfam00012
    Location:34725
    HSP70; Hsp70 protein
  2. NM_001317382.1NP_001304311.1  heat shock 70 kDa protein 4L isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate first exon compared to variant 1.The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC093591, AK302115, BC040560, BM679019, DB086945
    Consensus CDS
    CCDS82953.1
    UniProtKB/Swiss-Prot
    O95757
    UniProtKB/TrEMBL
    B4DXT2, E9PDE8
    Related
    ENSP00000425645.1, OTTHUMP00000219888, ENST00000505726.1, OTTHUMT00000364141
    Conserved Domains (2) summary
    pfam00012
    Location:11668
    HSP70; Hsp70 protein
    cl17037
    Location:11358
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  3. NM_001317383.1NP_001304312.1  heat shock 70 kDa protein 4L isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC093591, AK307464, BC040560, BM679019, DB051636
    UniProtKB/Swiss-Prot
    O95757
    Conserved Domains (2) summary
    pfam00012
    Location:3653
    HSP70; Hsp70 protein
    cl17037
    Location:2343
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  4. NM_014278.3NP_055093.2  heat shock 70 kDa protein 4L isoform 1

    See identical proteins and their annotated locations for NP_055093.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AC093591, BC040560, BM679019, DB051636
    Consensus CDS
    CCDS3734.1
    UniProtKB/Swiss-Prot
    O95757
    UniProtKB/TrEMBL
    A0A140VKE7
    Related
    ENSP00000296464.3, OTTHUMP00000164424, ENST00000296464.8, OTTHUMT00000257096
    Conserved Domains (1) summary
    cd11738
    Location:2384
    HSPA4L_NBD; Nucleotide-binding domain of HSPA4L

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    127781821..127834073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531745.3XP_011530047.1  heat shock 70 kDa protein 4L isoform X1

    Conserved Domains (2) summary
    PRK13929
    Location:4375
    PRK13929; rod-share determining protein MreBH; Provisional
    cd11738
    Location:2384
    HSPA4L_NBD; Nucleotide-binding domain of HSPA4L
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