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PHLDA1 pleckstrin homology like domain family A member 1 [ Homo sapiens (human) ]

Gene ID: 22822, updated on 21-Dec-2019

Summary

Official Symbol
PHLDA1provided by HGNC
Official Full Name
pleckstrin homology like domain family A member 1provided by HGNC
Primary source
HGNC:HGNC:8933
See related
Ensembl:ENSG00000139289 MIM:605335
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PHRIP; TDAG51; DT1P1B11
Summary
This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in salivary gland (RPKM 37.9), liver (RPKM 29.7) and 25 other tissues See more
Orthologs

Genomic context

See PHLDA1 in Genome Data Viewer
Location:
12q21.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (76025447..76031776, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (76419227..76425556, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369844 Neighboring gene HNF4 motif-containing MPRA enhancer 5 Neighboring gene uncharacterized LOC105369847 Neighboring gene density regulated re-initiation and release factor pseudogene Neighboring gene nucleosome assembly protein 1 like 1 Neighboring gene reticulon 4 interacting protein 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC131738

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
FasL biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
pleckstrin homology-like domain family A member 1
Names
PQ-rich protein
PQR protein
T-cell death-associated gene 51 protein
apoptosis-associated nuclear protein
proline- and glutamine-rich protein
proline- and histidine-rich protein
proline-histidine rich protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007350.3NP_031376.3  pleckstrin homology-like domain family A member 1

    See identical proteins and their annotated locations for NP_031376.3

    Status: REVIEWED

    Source sequence(s)
    AC011611, DR002699
    Consensus CDS
    CCDS31861.1
    UniProtKB/Swiss-Prot
    Q8WV24
    Related
    ENSP00000480767.1, ENST00000619060.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    76025447..76031776 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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