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ATF5 activating transcription factor 5 [ Homo sapiens (human) ]

Gene ID: 22809, updated on 5-Sep-2021

Summary

Official Symbol
ATF5provided by HGNC
Official Full Name
activating transcription factor 5provided by HGNC
Primary source
HGNC:HGNC:790
See related
Ensembl:ENSG00000169136 MIM:606398
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATFX; HMFN0395
Expression
Biased expression in liver (RPKM 197.1), thyroid (RPKM 55.7) and 2 other tissues See more
Orthologs
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Genomic context

See ATF5 in Genome Data Viewer
Location:
19q13.33
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (49928906..49933935)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50431959..50437193)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene AKT1 substrate 1 Neighboring gene TBC1 domain family member 17 Neighboring gene microRNA 4750 Neighboring gene interleukin 4 induced 1 Neighboring gene nucleoporin 62 Neighboring gene microRNA 4751 Neighboring gene sialic acid binding Ig like lectin 11 Neighboring gene sialic acid binding Ig like lectin 16

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34666

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cerebellar granule cell precursor proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in circadian rhythm IEA
Inferred from Electronic Annotation
more info
 
involved_in fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell cycle G2/M phase transition IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in olfactory bulb interneuron development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of centrosome cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cyclic AMP-dependent transcription factor ATF-5
Names
cAMP-dependent transcription factor ATF-5
transcription factor ATFx

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193646.2NP_001180575.1  cyclic AMP-dependent transcription factor ATF-5

    See identical proteins and their annotated locations for NP_001180575.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as alpha) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC011452
    Consensus CDS
    CCDS12789.1
    UniProtKB/Swiss-Prot
    Q9Y2D1
    UniProtKB/TrEMBL
    A0A024QZG3
    Related
    ENSP00000396954.1, ENST00000423777.7
    Conserved Domains (1) summary
    cd14692
    Location:209271
    bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain
  2. NM_001290746.2NP_001277675.1  cyclic AMP-dependent transcription factor ATF-5

    See identical proteins and their annotated locations for NP_001277675.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as beta) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AB021663, AB073613, AC011452, BU730542, HY011917
    Consensus CDS
    CCDS12789.1
    UniProtKB/Swiss-Prot
    Q9Y2D1
    UniProtKB/TrEMBL
    A0A024QZG3
    Conserved Domains (1) summary
    cd14692
    Location:209271
    bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain
  3. NM_012068.6NP_036200.2  cyclic AMP-dependent transcription factor ATF-5

    See identical proteins and their annotated locations for NP_036200.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AB021663, BU187153, BU730542, DA251296
    Consensus CDS
    CCDS12789.1
    UniProtKB/Swiss-Prot
    Q9Y2D1
    UniProtKB/TrEMBL
    A0A024QZG3
    Related
    ENSP00000470633.1, ENST00000595125.5
    Conserved Domains (1) summary
    cd14692
    Location:209271
    bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    49928906..49933935
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526629.3XP_011524931.1  cyclic AMP-dependent transcription factor ATF-5 isoform X1

    See identical proteins and their annotated locations for XP_011524931.1

    UniProtKB/Swiss-Prot
    Q9Y2D1
    UniProtKB/TrEMBL
    A0A024QZG3
    Conserved Domains (1) summary
    cd14692
    Location:209271
    bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain
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