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ATF5 activating transcription factor 5 [ Homo sapiens (human) ]

Gene ID: 22809, updated on 17-Jun-2018
Official Symbol
ATF5provided by HGNC
Official Full Name
activating transcription factor 5provided by HGNC
Primary source
HGNC:HGNC:790
See related
Ensembl:ENSG00000169136 MIM:606398; Vega:OTTHUMG00000183065
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATFX; HMFN0395
Expression
Biased expression in liver (RPKM 197.1), thyroid (RPKM 55.7) and 2 other tissues See more
Orthologs
See ATF5 in Genome Data Viewer
Location:
19q13.33
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (49928702..49933936)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50431959..50437193)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene AKT1 substrate 1 Neighboring gene TBC1 domain family member 17 Neighboring gene microRNA 4750 Neighboring gene interleukin 4 induced 1 Neighboring gene nucleoporin 62 Neighboring gene microRNA 4751 Neighboring gene sialic acid binding Ig like lectin 11 Neighboring gene sialic acid binding Ig like lectin 16 (gene/pseudogene)

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ34666

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA
Inferred from Sequence Alignment
more info
 
RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM
Inferred from Sequence Model
more info
PubMed 
RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription corepressor activity TAS
Traceable Author Statement
more info
PubMed 
transcription regulatory region DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC
Inferred by Curator
more info
 
tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cerebellar granule cell precursor proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
circadian rhythm IEA
Inferred from Electronic Annotation
more info
 
fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell cycle G2/M phase transition IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
olfactory bulb interneuron development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
regulation of centrosome cycle IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
cyclic AMP-dependent transcription factor ATF-5
Names
cAMP-dependent transcription factor ATF-5
transcription factor ATFx

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193646.1NP_001180575.1  cyclic AMP-dependent transcription factor ATF-5

    See identical proteins and their annotated locations for NP_001180575.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as alpha) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AB021663, AB073613, BF528888, BP378116, BU730542
    Consensus CDS
    CCDS12789.1
    UniProtKB/Swiss-Prot
    Q9Y2D1
    UniProtKB/TrEMBL
    A0A024QZG3
    Related
    ENSP00000396954.1, OTTHUMP00000270773, ENST00000423777.6, OTTHUMT00000464915
    Conserved Domains (1) summary
    cd14692
    Location:209271
    bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain
  2. NM_001290746.1NP_001277675.1  cyclic AMP-dependent transcription factor ATF-5

    See identical proteins and their annotated locations for NP_001277675.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as beta) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AB021663, AB073613, AC011452, BU730542, HY011917
    Consensus CDS
    CCDS12789.1
    UniProtKB/Swiss-Prot
    Q9Y2D1
    UniProtKB/TrEMBL
    A0A024QZG3
    Conserved Domains (1) summary
    cd14692
    Location:209271
    bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain
  3. NM_012068.5NP_036200.2  cyclic AMP-dependent transcription factor ATF-5

    See identical proteins and their annotated locations for NP_036200.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AB021663, BU187153, BU730542, DA251296
    Consensus CDS
    CCDS12789.1
    UniProtKB/Swiss-Prot
    Q9Y2D1
    UniProtKB/TrEMBL
    A0A024QZG3
    Related
    ENSP00000470633.1, OTTHUMP00000270799, ENST00000595125.5, OTTHUMT00000464972
    Conserved Domains (1) summary
    cd14692
    Location:209271
    bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    49928702..49933936
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526629.3XP_011524931.1  cyclic AMP-dependent transcription factor ATF-5 isoform X1

    See identical proteins and their annotated locations for XP_011524931.1

    UniProtKB/Swiss-Prot
    Q9Y2D1
    UniProtKB/TrEMBL
    A0A024QZG3
    Conserved Domains (1) summary
    cd14692
    Location:209271
    bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain
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