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MRAS muscle RAS oncogene homolog [ Homo sapiens (human) ]

Gene ID: 22808, updated on 5-Dec-2018

Summary

Official Symbol
MRASprovided by HGNC
Official Full Name
muscle RAS oncogene homologprovided by HGNC
Primary source
HGNC:HGNC:7227
See related
Ensembl:ENSG00000158186 MIM:608435
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
M-RAs; RRAS3; R-RAS3
Summary
This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Expression
Broad expression in fat (RPKM 37.4), heart (RPKM 23.2) and 16 other tissues See more
Orthologs

Genomic context

See MRAS in Genome Data Viewer
Location:
3q22.3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (138347648..138405535)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (138066490..138124377)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene debranching RNA lariats 1 Neighboring gene armadillo repeat containing 8 Neighboring gene NME/NM23 family member 9 Neighboring gene uncharacterized LOC105374129 Neighboring gene extended synaptotagmin 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
NHGRI GWA Catalog
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
NHGRI GWA Catalog
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
NHGRI GWA Catalog
New susceptibility locus for coronary artery disease on chromosome 3q22.3.
NHGRI GWA Catalog
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
NHGRI GWA Catalog

Pathways from BioSystems

  • Apelin signaling pathway, organism-specific biosystem (from KEGG)
    Apelin signaling pathway, organism-specific biosystemApelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various ti...
  • Autophagy - animal, organism-specific biosystem (from KEGG)
    Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
  • Autophagy - animal, conserved biosystem (from KEGG)
    Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
  • HTLV-I infection, organism-specific biosystem (from KEGG)
    HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • HTLV-I infection, conserved biosystem (from KEGG)
    HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
    MAPK Signaling Pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • Mitophagy - animal, organism-specific biosystem (from KEGG)
    Mitophagy - animal, organism-specific biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
  • Mitophagy - animal, conserved biosystem (from KEGG)
    Mitophagy - animal, conserved biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
  • Phospholipase D signaling pathway, organism-specific biosystem (from KEGG)
    Phospholipase D signaling pathway, organism-specific biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
  • Phospholipase D signaling pathway, conserved biosystem (from KEGG)
    Phospholipase D signaling pathway, conserved biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
  • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
    Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Proteoglycans in cancer, conserved biosystem (from KEGG)
    Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
    Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Rap1 signaling pathway, conserved biosystem (from KEGG)
    Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Ras signaling pathway, organism-specific biosystem (from KEGG)
    Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
  • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
    Regulation of Actin Cytoskeleton, organism-specific biosystemhttp://www.genome.jp/kegg/pathway/hsa/hsa04810.html
  • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
    Regulation of actin cytoskeleton, organism-specific biosystem
    Regulation of actin cytoskeleton
  • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
    Regulation of actin cytoskeleton, conserved biosystem
    Regulation of actin cytoskeleton

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ42964

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTP-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Ras protein signal transduction TAS
Traceable Author Statement
more info
PubMed 
actin cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
muscle organ development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ras-related protein M-Ras
Names
muscle and microspikes RAS
ras-related protein R-Ras3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085049.3NP_001078518.1  ras-related protein M-Ras isoform 1 precursor

    See identical proteins and their annotated locations for NP_001078518.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC022337, AF022080, AK123833, AK316071, BC017733, BC047690, CN356600
    Consensus CDS
    CCDS3100.1
    UniProtKB/Swiss-Prot
    O14807
    UniProtKB/TrEMBL
    Q6FGP0, Q8WVM9
    Related
    ENSP00000389682.2, ENST00000423968.6
    Conserved Domains (1) summary
    cd04145
    Location:12176
    M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3
  2. NM_001252090.1NP_001239019.1  ras-related protein M-Ras isoform 1 precursor

    See identical proteins and their annotated locations for NP_001239019.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC022497, AF493918, AK123833, AK316071, BC017733, BI488489
    Consensus CDS
    CCDS3100.1
    UniProtKB/Swiss-Prot
    O14807
    UniProtKB/TrEMBL
    Q6FGP0, Q8WVM9
    Related
    ENSP00000418356.1, ENST00000474559.1
    Conserved Domains (1) summary
    cd04145
    Location:12176
    M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3
  3. NM_001252091.1NP_001239020.1  ras-related protein M-Ras isoform 2 precursor

    See identical proteins and their annotated locations for NP_001239020.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an exon and uses a downstream, in-frame start codon, compared to variant 1. Variants 4, 5 and 6 encode the same isoform (2), which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK123833, AK316071, BC017733, DA235195, DA355883
    Consensus CDS
    CCDS58855.1
    UniProtKB/Swiss-Prot
    O14807
    UniProtKB/TrEMBL
    Q8WVM9
    Related
    ENSP00000484586.1, ENST00000614350.4
    Conserved Domains (1) summary
    cl21455
    Location:1100
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. NM_001252092.1NP_001239021.1  ras-related protein M-Ras isoform 2 precursor

    See identical proteins and their annotated locations for NP_001239021.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks an exon and uses a downstream, in-frame start codon, compared to variant 1. Variants 4, 5 and 6 encode the same isoform (2), which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK123833, AK295640, BC017733
    Consensus CDS
    CCDS58855.1
    UniProtKB/Swiss-Prot
    O14807
    UniProtKB/TrEMBL
    Q8WVM9
    Related
    ENSP00000419582.1, ENST00000464896.5
    Conserved Domains (1) summary
    cl21455
    Location:1100
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  5. NM_001252093.1NP_001239022.1  ras-related protein M-Ras isoform 2 precursor

    See identical proteins and their annotated locations for NP_001239022.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks an exon and uses a downstream, in-frame start codon, compared to variant 1. Variants 4, 5 and 6 encode the same isoform (2), which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AI216578, AK123833, AK316071, BC017733, CN356600
    Consensus CDS
    CCDS58855.1
    UniProtKB/Swiss-Prot
    O14807
    UniProtKB/TrEMBL
    Q8WVM9
    Related
    ENSP00000481637.1, ENST00000621127.4
    Conserved Domains (1) summary
    cl21455
    Location:1100
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  6. NM_012219.4NP_036351.3  ras-related protein M-Ras isoform 1 precursor

    See identical proteins and their annotated locations for NP_036351.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AK123833, AK124954, BC017733, DA235195
    Consensus CDS
    CCDS3100.1
    UniProtKB/Swiss-Prot
    O14807
    UniProtKB/TrEMBL
    Q6FGP0, Q8WVM9
    Related
    ENSP00000289104.4, ENST00000289104.8
    Conserved Domains (1) summary
    cd04145
    Location:12176
    M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    138347648..138405535
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453397.1XP_024309165.1  ras-related protein M-Ras isoform X2

  2. XM_005247229.2XP_005247286.1  ras-related protein M-Ras isoform X2

    See identical proteins and their annotated locations for XP_005247286.1

    Conserved Domains (1) summary
    cl21455
    Location:12150
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_024453398.1XP_024309166.1  ras-related protein M-Ras isoform X2

  4. XM_005247228.1XP_005247285.1  ras-related protein M-Ras isoform X1

    See identical proteins and their annotated locations for XP_005247285.1

    UniProtKB/Swiss-Prot
    O14807
    UniProtKB/TrEMBL
    Q6FGP0
    Conserved Domains (1) summary
    cd04145
    Location:12176
    M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3
  5. XM_024453396.1XP_024309164.1  ras-related protein M-Ras isoform X1

    Conserved Domains (1) summary
    cd04145
    Location:12176
    M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3
  6. XM_017005887.2XP_016861376.1  ras-related protein M-Ras isoform X1

    UniProtKB/Swiss-Prot
    O14807
    UniProtKB/TrEMBL
    Q6FGP0
    Conserved Domains (1) summary
    cd04145
    Location:12176
    M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3
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