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MRAS muscle RAS oncogene homolog [ Homo sapiens (human) ]

Gene ID: 22808, updated on 23-Oct-2022

Summary

Official Symbol
MRASprovided by HGNC
Official Full Name
muscle RAS oncogene homologprovided by HGNC
Primary source
HGNC:HGNC:7227
See related
Ensembl:ENSG00000158186 MIM:608435; AllianceGenome:HGNC:7227
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NS11; M-RAs; RRAS3; R-RAS3
Summary
This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Expression
Broad expression in fat (RPKM 37.4), heart (RPKM 23.2) and 16 other tissues See more
Orthologs
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Genomic context

See MRAS in Genome Data Viewer
Location:
3q22.3
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (138347648..138405535)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (141088198..141146101)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (138066490..138124377)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing 8 Neighboring gene NME/NM23 family member 9 Neighboring gene uncharacterized LOC124909438 Neighboring gene extended synaptotagmin 3 Neighboring gene centrosomal protein 70

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Noonan syndrome 11
MedGen: C5193130 OMIM: 618499 GeneReviews: Noonan Syndrome
Compare labs

EBI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
EBI GWAS Catalog
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
EBI GWAS Catalog
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
EBI GWAS Catalog
New susceptibility locus for coronary artery disease on chromosome 3q22.3.
EBI GWAS Catalog
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ42964

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
 
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTP-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in actin cytoskeleton organization TAS
Traceable Author Statement
more info
 
involved_in cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ras-related protein M-Ras
Names
muscle and microspikes RAS
ras-related protein R-Ras3
NP_001078518.1
NP_001239019.1
NP_001239020.1
NP_001239021.1
NP_001239022.1
NP_036351.3
XP_005247285.1
XP_005247286.1
XP_024309164.1
XP_047303651.1
XP_047303652.1
XP_047303653.1
XP_047303654.1
XP_047303655.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085049.3NP_001078518.1  ras-related protein M-Ras isoform 1 precursor

    See identical proteins and their annotated locations for NP_001078518.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC022337, AF022080, AK123833, AK316071, BC017733, BC047690, CN356600
    Consensus CDS
    CCDS3100.1
    UniProtKB/Swiss-Prot
    O14807, Q86WX8
    UniProtKB/TrEMBL
    D3DNE8, Q6FGP0, Q8WVM9
    Related
    ENSP00000389682.2, ENST00000423968.7
    Conserved Domains (1) summary
    cd04145
    Location:12176
    M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3
  2. NM_001252090.2NP_001239019.1  ras-related protein M-Ras isoform 1 precursor

    See identical proteins and their annotated locations for NP_001239019.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC022497, AF493918, AK123833, AK316071, BC017733, BI488489
    Consensus CDS
    CCDS3100.1
    UniProtKB/Swiss-Prot
    O14807, Q86WX8
    UniProtKB/TrEMBL
    D3DNE8, Q6FGP0, Q8WVM9
    Related
    ENSP00000418356.1, ENST00000474559.1
    Conserved Domains (1) summary
    cd04145
    Location:12176
    M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3
  3. NM_001252091.1NP_001239020.1  ras-related protein M-Ras isoform 2 precursor

    See identical proteins and their annotated locations for NP_001239020.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an exon and uses a downstream, in-frame start codon, compared to variant 1. Variants 4, 5 and 6 encode the same isoform (2), which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK123833, AK316071, BC017733, DA235195, DA355883
    Consensus CDS
    CCDS58855.1
    UniProtKB/Swiss-Prot
    O14807
    UniProtKB/TrEMBL
    Q8WVM9
    Related
    ENSP00000484586.1, ENST00000614350.4
    Conserved Domains (1) summary
    cl38936
    Location:1100
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. NM_001252092.2NP_001239021.1  ras-related protein M-Ras isoform 2 precursor

    See identical proteins and their annotated locations for NP_001239021.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks an exon and uses a downstream, in-frame start codon, compared to variant 1. Variants 4, 5 and 6 encode the same isoform (2), which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK123833, AK295640, BC017733
    Consensus CDS
    CCDS58855.1
    UniProtKB/Swiss-Prot
    O14807
    UniProtKB/TrEMBL
    Q8WVM9
    Related
    ENSP00000419582.1, ENST00000464896.5
    Conserved Domains (1) summary
    cl38936
    Location:1100
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  5. NM_001252093.2NP_001239022.1  ras-related protein M-Ras isoform 2 precursor

    See identical proteins and their annotated locations for NP_001239022.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks an exon and uses a downstream, in-frame start codon, compared to variant 1. Variants 4, 5 and 6 encode the same isoform (2), which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC022337, AI216578, AK123833, AK316071, BC017733, CN356600
    Consensus CDS
    CCDS58855.1
    UniProtKB/Swiss-Prot
    O14807
    UniProtKB/TrEMBL
    Q8WVM9
    Related
    ENSP00000481637.1, ENST00000621127.4
    Conserved Domains (1) summary
    cl38936
    Location:1100
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  6. NM_012219.4NP_036351.3  ras-related protein M-Ras isoform 1 precursor

    See identical proteins and their annotated locations for NP_036351.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AK123833, AK124954, BC017733, DA235195
    Consensus CDS
    CCDS3100.1
    UniProtKB/Swiss-Prot
    O14807, Q86WX8
    UniProtKB/TrEMBL
    D3DNE8, Q6FGP0, Q8WVM9
    Related
    ENSP00000289104.4, ENST00000289104.8
    Conserved Domains (1) summary
    cd04145
    Location:12176
    M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    138347648..138405535
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047447696.1XP_047303652.1  ras-related protein M-Ras isoform X1

    UniProtKB/Swiss-Prot
    Q86WX8
    UniProtKB/TrEMBL
    D3DNE8
  2. XM_047447697.1XP_047303653.1  ras-related protein M-Ras isoform X1

    UniProtKB/Swiss-Prot
    Q86WX8
    UniProtKB/TrEMBL
    D3DNE8
  3. XM_047447695.1XP_047303651.1  ras-related protein M-Ras isoform X1

    UniProtKB/Swiss-Prot
    Q86WX8
    UniProtKB/TrEMBL
    D3DNE8
  4. XM_047447698.1XP_047303654.1  ras-related protein M-Ras isoform X1

    UniProtKB/Swiss-Prot
    Q86WX8
    UniProtKB/TrEMBL
    D3DNE8
  5. XM_005247228.2XP_005247285.1  ras-related protein M-Ras isoform X1

    See identical proteins and their annotated locations for XP_005247285.1

    UniProtKB/Swiss-Prot
    O14807, Q86WX8
    UniProtKB/TrEMBL
    D3DNE8, Q6FGP0
    Conserved Domains (1) summary
    cd04145
    Location:12176
    M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3
  6. XM_047447699.1XP_047303655.1  ras-related protein M-Ras isoform X1

    UniProtKB/Swiss-Prot
    Q86WX8
    UniProtKB/TrEMBL
    D3DNE8
  7. XM_005247229.3XP_005247286.1  ras-related protein M-Ras isoform X2

    See identical proteins and their annotated locations for XP_005247286.1

    Conserved Domains (1) summary
    cl38936
    Location:12150
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  8. XM_024453396.2XP_024309164.1  ras-related protein M-Ras isoform X1

    UniProtKB/Swiss-Prot
    Q86WX8
    UniProtKB/TrEMBL
    D3DNE8
    Conserved Domains (1) summary
    cd04145
    Location:12176
    M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    141088198..141146101
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)