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Tlk1 tousled-like kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 228012, updated on 9-Mar-2023

Summary

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Official Symbol
Tlk1provided by MGI
Official Full Name
tousled-like kinase 1provided by MGI
Primary source
MGI:MGI:2441683
See related
Ensembl:ENSMUSG00000041997 AllianceGenome:MGI:2441683
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930545J15Rik
Summary
Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including intracellular protein transport; peptidyl-serine phosphorylation; and regulation of chromatin assembly or disassembly. Predicted to act upstream of or within cellular response to DNA damage stimulus; chromatin organization; and phosphorylation. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system gland. Orthologous to human TLK1 (tousled like kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 13.5), liver E14.5 (RPKM 11.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tlk1 in Genome Data Viewer
Location:
2; 2 C2
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (70542751..70656505, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (70712407..70825816, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 46745 Neighboring gene golgi reassembly stacking protein 2 Neighboring gene predicted gene, 38528 Neighboring gene predicted gene, 39842 Neighboring gene F-box and WD-40 domain protein 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The circular RNA TLK1 exacerbates myocardial ischemia/reperfusion injury via targeting miR-214/RIPK1 through TNF signaling pathway. Song YF, et al. Free Radic Biol Med, 2020 Aug 1. PMID 32445866
  2. Tousled-like kinase 1 is a negative regulator of core transcription factors in murine embryonic stem cells. Lee J, et al. Sci Rep, 2018 Jan 10. PMID 29321513, Free PMC Article
  3. The radioresistance kinase TLK1B protects the cells by promoting repair of double strand breaks. Sunavala-Dossabhoy G, et al. BMC Mol Biol, 2005 Sep 12. PMID 16156902, Free PMC Article
  4. Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation. Liu H, et al. Dev Cell, 2017 May 22. PMID 28535374, Free PMC Article
  5. The TLK1-Nek1 axis promotes prostate cancer progression. Singh V, et al. Cancer Lett, 2019 Jul 1. PMID 30928383

See all (30) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The circular RNA TLK1 exacerbates myocardial ischemia/reperfusion injury via targeting miR-214/RIPK1 through TNF signaling pathway.
    Title: The circular RNA TLK1 exacerbates myocardial ischemia/reperfusion injury via targeting miR-214/RIPK1 through TNF signaling pathway.
  2. our data suggest that Tlk1 negatively regulates the expression of pluripotency factors, thereby contributing to the scheduled differentiation of mouse ESCs.
    Title: Tousled-like kinase 1 is a negative regulator of core transcription factors in murine embryonic stem cells.
  3. TLK1 and TLK2 have largely redundant roles in genome maintenance.
    Title: Differential requirements for Tousled-like kinases 1 and 2 in mammalian development.
  4. present direct evidence that TLK1B can promote repair of linearized plasmids with incompatible ends that require processing prior to ligation.
    Title: TLK1B promotes repair of DSBs via its interaction with Rad9 and Asf1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chromatin organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase tousled-like 1
NP_001349892.1
NP_766252.2
XP_006499251.1
XP_006499252.1
XP_006499254.1
XP_006499256.1
XP_017173069.1
XP_017173070.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362963.1 → NP_001349892.1  serine/threonine-protein kinase tousled-like 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL928868, BX000490
    Conserved Domains (1) summary
    cd14040
    Location:401 → 699
    STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

  2. NM_172664.3 → NP_766252.2  serine/threonine-protein kinase tousled-like 1 isoform 1

    See identical proteins and their annotated locations for NP_766252.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC051641
    Consensus CDS
    CCDS50599.1
    UniProtKB/Swiss-Prot
    Q8C0V0
    Related
    ENSMUSP00000035961.9, ENSMUST00000038584.9
    Conserved Domains (2) summary
    smart00220
    Location:467 → 734
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14040
    Location:449 → 747
    STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

RNA

  1. NR_156420.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL928868, BC057369, BX000490
    Related
    ENSMUST00000135128.8

  2. NR_156421.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK045308, BX000490
    Related
    ENSMUST00000124629.2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    70542751..70656505 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499193.2 → XP_006499256.1  serine/threonine-protein kinase tousled-like 1 isoform X3

    See identical proteins and their annotated locations for XP_006499256.1

    Conserved Domains (1) summary
    cd14040
    Location:232 → 530
    STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

  2. XM_006499189.4 → XP_006499252.1  serine/threonine-protein kinase tousled-like 1 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:449 → 711
    PKc_like; Protein Kinases, catalytic domain

  3. XM_006499191.3 → XP_006499254.1  serine/threonine-protein kinase tousled-like 1 isoform X3

    See identical proteins and their annotated locations for XP_006499254.1

    Conserved Domains (1) summary
    cd14040
    Location:232 → 530
    STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

  4. XM_006499188.5 → XP_006499251.1  serine/threonine-protein kinase tousled-like 1 isoform X1

    See identical proteins and their annotated locations for XP_006499251.1

    Conserved Domains (1) summary
    cd14040
    Location:417 → 715
    STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

  5. XM_017317581.1 → XP_017173070.1  serine/threonine-protein kinase tousled-like 1 isoform X3

    Conserved Domains (1) summary
    cd14040
    Location:232 → 530
    STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

  6. XM_017317580.3 → XP_017173069.1  serine/threonine-protein kinase tousled-like 1 isoform X3

    Conserved Domains (1) summary
    cd14040
    Location:232 → 530
    STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

RNA

  1. XR_003952263.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C0V0.2 GenPept UniProtKB/Swiss-Prot:Q8C0V0

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