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ITGA11 integrin subunit alpha 11 [ Homo sapiens (human) ]

Gene ID: 22801, updated on 11-Jun-2021

Summary

Official Symbol
ITGA11provided by HGNC
Official Full Name
integrin subunit alpha 11provided by HGNC
Primary source
HGNC:HGNC:6136
See related
Ensembl:ENSG00000137809 MIM:604789
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HsT18964
Summary
This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined. [provided by RefSeq, Jul 2008]
Expression
Biased expression in endometrium (RPKM 12.1), urinary bladder (RPKM 2.7) and 13 other tissues See more
Orthologs
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Genomic context

See ITGA11 in Genome Data Viewer
Location:
15q23
Exon count:
31
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (68296532..68432312, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (68588870..68724502, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 40 Neighboring gene fem-1 homolog B Neighboring gene uncharacterized LOC105370873 Neighboring gene coronin 2B Neighboring gene Sharpr-MPRA regulatory region 237

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
GeneReviews: Not available
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
GeneReviews: Not available
Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables collagen binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables collagen binding involved in cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables collagen receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046911.1 RefSeqGene

    Range
    4998..140629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001004439.2NP_001004439.1  integrin alpha-11 precursor

    See identical proteins and their annotated locations for NP_001004439.1

    Status: REVIEWED

    Source sequence(s)
    AC021553, AC100825, AF109681, AF137378, AK095863, AL359064, BX496541, CN358985
    Consensus CDS
    CCDS45291.1
    UniProtKB/Swiss-Prot
    Q9UKX5
    UniProtKB/TrEMBL
    B3KTN6
    Related
    ENSP00000327290.7, ENST00000315757.9
    Conserved Domains (3) summary
    smart00191
    Location:538592
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:163341
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam08441
    Location:6351034
    Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    68296532..68432312 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521363.2XP_011519665.1  integrin alpha-11 isoform X1

    Conserved Domains (3) summary
    smart00191
    Location:469523
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:94272
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam08441
    Location:566965
    Integrin_alpha2; Integrin alpha
  2. XM_005254228.3XP_005254285.1  integrin alpha-11 isoform X2

    Conserved Domains (3) summary
    smart00191
    Location:436490
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:61239
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam08441
    Location:533932
    Integrin_alpha2; Integrin alpha

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_012211.3: Suppressed sequence

    Description
    NM_012211.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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