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NID2 nidogen 2 [ Homo sapiens (human) ]

Gene ID: 22795, updated on 7-Jun-2020

Summary

Official Symbol
NID2provided by HGNC
Official Full Name
nidogen 2provided by HGNC
Primary source
HGNC:HGNC:13389
See related
Ensembl:ENSG00000087303 MIM:605399
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NID-2
Summary
This gene encodes a member of the nidogen family of basement membrane proteins. This protein is a cell-adhesion protein that binds collagens I and IV and laminin and may be involved in maintaining the structure of the basement membrane.[provided by RefSeq, Jun 2010]
Expression
Broad expression in placenta (RPKM 30.5), thyroid (RPKM 21.7) and 16 other tissues See more
Orthologs

Genomic context

See NID2 in Genome Data Viewer
Location:
14q22.1
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (52004809..52069059, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (52471520..52535949, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370497 Neighboring gene Sharpr-MPRA regulatory region 5932 Neighboring gene RNA transcription, translation and transport factor Neighboring gene uncharacterized LOC105378180 Neighboring gene CAGE-defined high expression enhancer upstream of NID2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide gene-environment interaction analysis for tobacco smoke and lung cancer susceptibility.
NHGRI GWA Catalog
Framingham Heart Study genome-wide association: results for pulmonary function measures.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
collagen binding TAS
Traceable Author Statement
more info
PubMed 
extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
basement membrane organization TAS
Traceable Author Statement
more info
PubMed 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix organization TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
nidogen-2
Names
osteonidogen

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007361.4NP_031387.3  nidogen-2 precursor

    See identical proteins and their annotated locations for NP_031387.3

    Status: REVIEWED

    Source sequence(s)
    AJ223500, AL118557, BM719690, CA413165
    Consensus CDS
    CCDS9706.1
    UniProtKB/Swiss-Prot
    Q14112
    Related
    ENSP00000216286.4, ENST00000216286.10
    Conserved Domains (6) summary
    smart00135
    Location:12211265
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:801843
    EGF_CA; Calcium-binding EGF-like domain
    smart00539
    Location:108273
    NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
    smart00682
    Location:525757
    G2F; G2 nidogen domain and fibulin
    cd00191
    Location:9391005
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    pfam12947
    Location:896929
    EGF_3; EGF domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    52004809..52069059 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267407.5XP_005267464.1  nidogen-2 isoform X3

    Conserved Domains (6) summary
    smart00135
    Location:11731217
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:801843
    EGF_CA; Calcium-binding EGF-like domain
    smart00539
    Location:108273
    NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
    smart00682
    Location:525757
    G2F; G2 nidogen domain and fibulin
    cd00191
    Location:891957
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    pfam12947
    Location:848881
    EGF_3; EGF domain
  2. XM_005267406.5XP_005267463.1  nidogen-2 isoform X2

    Conserved Domains (6) summary
    smart00135
    Location:12001244
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:828870
    EGF_CA; Calcium-binding EGF-like domain
    smart00539
    Location:108273
    NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
    smart00682
    Location:552784
    G2F; G2 nidogen domain and fibulin
    cd00191
    Location:918984
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    pfam12947
    Location:875908
    EGF_3; EGF domain
  3. XM_005267405.5XP_005267462.1  nidogen-2 isoform X1

    Conserved Domains (6) summary
    smart00135
    Location:12481292
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:828870
    EGF_CA; Calcium-binding EGF-like domain
    smart00539
    Location:108273
    NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
    smart00682
    Location:552784
    G2F; G2 nidogen domain and fibulin
    cd00191
    Location:9661032
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    pfam12947
    Location:923956
    EGF_3; EGF domain
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