U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Zyx zyxin [ Mus musculus (house mouse) ]

Gene ID: 22793, updated on 6-Jun-2024

Summary

Official Symbol
Zyxprovided by MGI
Official Full Name
zyxinprovided by MGI
Primary source
MGI:MGI:103072
See related
Ensembl:ENSMUSG00000029860 AllianceGenome:MGI:103072
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9530098H06Rik
Summary
Predicted to enable metal ion binding activity. Involved in cell-matrix adhesion; integrin-mediated signaling pathway; and transforming growth factor beta receptor signaling pathway. Acts upstream of or within cellular response to interferon-gamma. Located in focal adhesion and phagocytic vesicle. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut; and thymus. Orthologous to human ZYX (zyxin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 88.7), ovary adult (RPKM 71.5) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Zyx in Genome Data Viewer
Location:
6 B2.1; 6 20.64 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (42326507..42337158)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (42349511..42360213)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene chloride channel, voltage-sensitive 1 Neighboring gene family with sequence similarity 131, member B Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:42293816-42293969 Neighboring gene predicted gene, 24611 Neighboring gene RIKEN cDNA 2010310C07 gene Neighboring gene Eph receptor A1 Neighboring gene STARR-seq mESC enhancer starr_15718 Neighboring gene taste receptor, type 2, member 143

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289617.2NP_001276546.1  zyxin isoform a

    See identical proteins and their annotated locations for NP_001276546.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC153915
    Consensus CDS
    CCDS20066.1
    UniProtKB/Swiss-Prot
    P70461, Q3UGQ3, Q62523
    UniProtKB/TrEMBL
    Q3TCR9
    Related
    ENSMUSP00000126622.2, ENSMUST00000164375.4
    Conserved Domains (4) summary
    cd09353
    Location:436495
    LIM2_Zyxin; The second LIM domain of Zyxin
    cd09435
    Location:496562
    LIM3_Zyxin; The third LIM domain of Zyxin
    PHA03247
    Location:175368
    PHA03247; large tegument protein UL36; Provisional
    cl02475
    Location:343429
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  2. NM_001289618.2NP_001276547.1  zyxin isoform b

    See identical proteins and their annotated locations for NP_001276547.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon and differs in the 3' UTR, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 3 and 4 encode the same isoform (b).
    Source sequence(s)
    AC153915
    Consensus CDS
    CCDS85034.1
    UniProtKB/TrEMBL
    Q3TCR9, Q7TQE2
    Related
    ENSMUSP00000145236.2, ENSMUST00000203401.3
    Conserved Domains (4) summary
    cd09353
    Location:405464
    LIM2_Zyxin; The second LIM domain of Zyxin
    cd09435
    Location:465531
    LIM3_Zyxin; The third LIM domain of Zyxin
    PHA03247
    Location:5311
    PHA03247; large tegument protein UL36; Provisional
    cl02475
    Location:312398
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  3. NM_001289619.2NP_001276548.1  zyxin isoform b

    See identical proteins and their annotated locations for NP_001276548.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 3 and 4 encode the same isoform (b).
    Source sequence(s)
    AC153915
    Consensus CDS
    CCDS85034.1
    UniProtKB/TrEMBL
    Q3TCR9, Q7TQE2
    Related
    ENSMUSP00000070427.8, ENSMUST00000070635.13
    Conserved Domains (4) summary
    cd09353
    Location:405464
    LIM2_Zyxin; The second LIM domain of Zyxin
    cd09435
    Location:465531
    LIM3_Zyxin; The third LIM domain of Zyxin
    PHA03247
    Location:5311
    PHA03247; large tegument protein UL36; Provisional
    cl02475
    Location:312398
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  4. NM_001415802.1NP_001402731.1  zyxin isoform a

    Status: VALIDATED

    Source sequence(s)
    AC153915
    UniProtKB/Swiss-Prot
    P70461, Q3UGQ3, Q62523
    UniProtKB/TrEMBL
    Q3TCR9
  5. NM_011777.4NP_035907.1  zyxin isoform a

    See identical proteins and their annotated locations for NP_035907.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC153915
    Consensus CDS
    CCDS20066.1
    UniProtKB/Swiss-Prot
    P70461, Q3UGQ3, Q62523
    UniProtKB/TrEMBL
    Q3TCR9
    Related
    ENSMUSP00000145451.2, ENSMUST00000203652.3
    Conserved Domains (4) summary
    cd09353
    Location:436495
    LIM2_Zyxin; The second LIM domain of Zyxin
    cd09435
    Location:496562
    LIM3_Zyxin; The third LIM domain of Zyxin
    PHA03247
    Location:175368
    PHA03247; large tegument protein UL36; Provisional
    cl02475
    Location:343429
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    42326507..42337158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255327.2XP_030111187.1  zyxin isoform X2

    UniProtKB/TrEMBL
    Q3TCR9, Q7TQE2
    Conserved Domains (4) summary
    cd09353
    Location:405464
    LIM2_Zyxin; The second LIM domain of Zyxin
    cd09435
    Location:465531
    LIM3_Zyxin; The third LIM domain of Zyxin
    PHA03247
    Location:5311
    PHA03247; large tegument protein UL36; Provisional
    cl02475
    Location:312398
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  2. XM_036166031.1XP_036021924.1  zyxin isoform X2

    UniProtKB/TrEMBL
    Q3TCR9, Q7TQE2
    Conserved Domains (4) summary
    cd09353
    Location:405464
    LIM2_Zyxin; The second LIM domain of Zyxin
    cd09435
    Location:465531
    LIM3_Zyxin; The third LIM domain of Zyxin
    PHA03247
    Location:5311
    PHA03247; large tegument protein UL36; Provisional
    cl02475
    Location:312398
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  3. XM_036166032.1XP_036021925.1  zyxin isoform X3

    UniProtKB/TrEMBL
    Q8CD55
    Conserved Domains (4) summary
    cd09353
    Location:337396
    LIM2_Zyxin; The second LIM domain of Zyxin
    cd09435
    Location:397463
    LIM3_Zyxin; The third LIM domain of Zyxin
    PHA03247
    Location:76269
    PHA03247; large tegument protein UL36; Provisional
    cl02475
    Location:244330
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers