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Slc30a4 solute carrier family 30 (zinc transporter), member 4 [ Mus musculus (house mouse) ]

Gene ID: 22785, updated on 31-Jan-2019

Summary

Official Symbol
Slc30a4provided by MGI
Official Full Name
solute carrier family 30 (zinc transporter), member 4provided by MGI
Primary source
MGI:MGI:1345282
See related
Ensembl:ENSMUSG00000005802
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
lm; Znt4; znT-4
Expression
Ubiquitous expression in testis adult (RPKM 14.9), placenta adult (RPKM 9.8) and 26 other tissues See more
Orthologs

Genomic context

See Slc30a4 in Genome Data Viewer
Location:
2 E5; 2 60.65 cM
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (122681233..122702663, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (122506975..122528399, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 5-like 1 Neighboring gene expressed sequence AA467197 Neighboring gene microRNA 147 Neighboring gene RIKEN cDNA 4930417H01 gene Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 6, pallidin, opposite strand

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Targeted (1) 
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cation transport IEA
Inferred from Electronic Annotation
more info
 
ion transport IEA
Inferred from Electronic Annotation
more info
 
regulation of sequestering of zinc ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of sequestering of zinc ion ISO
Inferred from Sequence Orthology
more info
 
response to toxic substance ISO
Inferred from Sequence Orthology
more info
 
response to zinc ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
zinc ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
zinc ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
late endosome ISO
Inferred from Sequence Orthology
more info
 
lysosome IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc transporter 4
Names
lethal milk protein
solute carrier family 30 (zinc transporter), member 4; zinc transporter 4
solute carrier family 30 member 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290993.1NP_001277922.1  zinc transporter 4 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AK134245, AL772253, AW125676, CO432407, CV556160
    Consensus CDS
    CCDS71131.1
    UniProtKB/Swiss-Prot
    O35149
    UniProtKB/TrEMBL
    A2AK40
    Related
    ENSMUSP00000097056.3, ENSMUST00000099457.3
    Conserved Domains (2) summary
    TIGR01297
    Location:131365
    CDF; cation diffusion facilitator family transporter
    pfam01545
    Location:130284
    Cation_efflux; Cation efflux family
  2. NM_011774.3NP_035904.2  zinc transporter 4 isoform a

    See identical proteins and their annotated locations for NP_035904.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK134245, AL772253, AW125676, CO432407, CV556160
    Consensus CDS
    CCDS16667.1
    UniProtKB/Swiss-Prot
    O35149
    Related
    ENSMUSP00000005952.4, ENSMUST00000005952.10
    Conserved Domains (2) summary
    TIGR01297
    Location:123414
    CDF; cation diffusion facilitator family transporter
    pfam01545
    Location:123333
    Cation_efflux; Cation efflux family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

    Range
    122681233..122702663 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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