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Gtdc1 glycosyltransferase-like domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 227835, updated on 2-Nov-2024

Summary

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Official Symbol
Gtdc1provided by MGI
Official Full Name
glycosyltransferase-like domain containing 1provided by MGI
Primary source
MGI:MGI:2444269
See related
Ensembl:ENSMUSG00000036890 AllianceGenome:MGI:2444269
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
QTMAN; E330008O22Rik
Summary
Predicted to enable tRNA-queuosine(34) beta-mannosyltransferase activity. Predicted to be involved in regulation of translation and tRNA modification. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in central nervous system. Orthologous to human GTDC1 (glycosyltransferase like domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in cortex adult (RPKM 8.8), CNS E18 (RPKM 7.0) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Gtdc1 in Genome Data Viewer
Location:
2 B; 2 27.27 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (44454420..44817761, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (44564412..44927717, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39805 Neighboring gene STARR-seq mESC enhancer starr_04394 Neighboring gene STARR-seq mESC enhancer starr_04398 Neighboring gene predicted gene, 39806 Neighboring gene predicted gene, 52509 Neighboring gene predicted gene, 39807 Neighboring gene STARR-seq mESC enhancer starr_04399 Neighboring gene centromere protein C1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:44816144-44816341 Neighboring gene STARR-seq mESC enhancer starr_04400 Neighboring gene zinc finger E-box binding homeobox 2 Neighboring gene microRNA 5129 Neighboring gene zinc finger E-box binding homeobox 2, opposite strand

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  2. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables tRNA-queuosine(34) beta-mannosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA-queuosine(34) beta-mannosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tRNA modification ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA modification ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
tRNA-queuosine alpha-mannosyltransferase; glycosyltransferase-like domain-containing protein 1
NP_001349915.1
NP_001349916.1
NP_766250.2
XP_011237393.1
XP_030105978.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362986.1 → NP_001349915.1  tRNA-queuosine alpha-mannosyltransferase

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same protein.
    Source sequence(s)
    AL844891, AL929120, AL935057, BX293544
    Consensus CDS
    CCDS71050.1
    UniProtKB/Swiss-Prot
    A2AQR9, A2AQS2, A2AVU2, Q3TQ41, Q80US3, Q8BW56, Q8C1B8
    UniProtKB/TrEMBL
    G8JL42
    Conserved Domains (2) summary
    cd01635
    Location:275 → 386
    Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology
    pfam12038
    Location:2 → 164
    DUF3524; Domain of unknown function (DUF3524)

  2. NM_001362987.1 → NP_001349916.1  tRNA-queuosine alpha-mannosyltransferase

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same protein.
    Source sequence(s)
    AL844891, AL929120, AL935057, BX293544
    Consensus CDS
    CCDS71050.1
    UniProtKB/Swiss-Prot
    A2AQR9, A2AQS2, A2AVU2, Q3TQ41, Q80US3, Q8BW56, Q8C1B8
    UniProtKB/TrEMBL
    G8JL42
    Related
    ENSMUSP00000038119.7, ENSMUST00000049051.13
    Conserved Domains (2) summary
    cd01635
    Location:275 → 386
    Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology
    pfam12038
    Location:2 → 164
    DUF3524; Domain of unknown function (DUF3524)

  3. NM_172662.3 → NP_766250.2  tRNA-queuosine alpha-mannosyltransferase

    See identical proteins and their annotated locations for NP_766250.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents a protein-coding transcript, as do variants 2 and 3. Variants 1-3 all encode the same protein.
    Source sequence(s)
    AK054272, BC052069
    Consensus CDS
    CCDS71050.1
    UniProtKB/Swiss-Prot
    A2AQR9, A2AQS2, A2AVU2, Q3TQ41, Q80US3, Q8BW56, Q8C1B8
    UniProtKB/TrEMBL
    G8JL42
    Related
    ENSMUSP00000108429.2, ENSMUST00000112810.8
    Conserved Domains (2) summary
    cd01635
    Location:275 → 386
    Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology
    pfam12038
    Location:2 → 164
    DUF3524; Domain of unknown function (DUF3524)

RNA

  1. NR_156429.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK038057, AL929120, AL935057

  2. NR_156430.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK163943, AL935057
    Related
    ENSMUST00000100127.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    44454420..44817761 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239091.3 → XP_011237393.1  glycosyltransferase-like domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011237393.1

    UniProtKB/Swiss-Prot
    A2AQR9, A2AQS2, A2AVU2, Q3TQ41, Q80US3, Q8BW56, Q8C1B8
    UniProtKB/TrEMBL
    G8JL42
    Conserved Domains (2) summary
    cd01635
    Location:275 → 386
    Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology
    pfam12038
    Location:2 → 164
    DUF3524; Domain of unknown function (DUF3524)

  2. XM_030250118.2 → XP_030105978.1  glycosyltransferase-like domain-containing protein 1 isoform X2

    Conserved Domains (1) summary
    pfam12038
    Location:2 → 164
    DUF3524; Domain of unknown function (DUF3524)

RNA

  1. XR_003952199.2 RNA Sequence

  2. XR_003952196.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BW56.2 GenPept UniProtKB/Swiss-Prot:Q8BW56

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