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Ikzf2 IKAROS family zinc finger 2 [ Mus musculus (house mouse) ]

Gene ID: 22779, updated on 7-Mar-2023

Summary

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Official Symbol
Ikzf2provided by MGI
Official Full Name
IKAROS family zinc finger 2provided by MGI
Primary source
MGI:MGI:1342541
See related
Ensembl:ENSMUSG00000025997 AllianceGenome:MGI:1342541
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Helios; Zfpn1a2; Znfn1a2; A730095J18Rik
Summary
Enables identical protein binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in early conceptus and genitourinary system. Orthologous to human IKZF2 (IKAROS family zinc finger 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 4.1), thymus adult (RPKM 2.6) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Ikzf2 in Genome Data Viewer
Location:
1; 1 C3
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (69570366..69726510, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (69531207..69687351, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene PC-esterase domain containing 1C, pseudogene Neighboring gene predicted gene 28497 Neighboring gene predicted gene, 53559 Neighboring gene predicted gene, 29822 Neighboring gene sperm associated antigen 16 Neighboring gene predicted gene, 23879

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ikzf2 Regulates the Development of ICOS(+) Th Cells to Mediate Immune Response in the Spleen of S. japonicum-Infected C57BL/6 Mice. Xie S, et al. Front Immunol, 2021. PMID 34475870, Free PMC Article
  2. Lack of Helios During Neural Development Induces Adult Schizophrenia-Like Behaviors Associated With Aberrant Levels of the TRIF-Recruiter Protein WDFY1. Sancho-Balsells A, et al. Front Cell Neurosci, 2020. PMID 32477064, Free PMC Article
  3. Helios(+) and Helios(-) Treg subpopulations are phenotypically and functionally distinct and express dissimilar TCR repertoires. Thornton AM, et al. Eur J Immunol, 2019 Mar. PMID 30620397, Free PMC Article
  4. IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation. Park SM, et al. Cell Stem Cell, 2019 Jan 3. PMID 30472158, Free PMC Article
  5. Generation of Helios reporter mice and an evaluation of the suppressive capacity of Helios(+) regulatory T cells in vitro. Sugita K, et al. Exp Dermatol, 2015 Jul. PMID 25846704

See all (63) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells.
    Title: Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells.
  2. Ikzf2 Regulates the Development of ICOS(+) Th Cells to Mediate Immune Response in the Spleen of S. japonicum-Infected C57BL/6 Mice.
    Title: Ikzf2 Regulates the Development of ICOS(+) Th Cells to Mediate Immune Response in the Spleen of S. japonicum-Infected C57BL/6 Mice.
  3. RNA-Binding Protein ZFP36L2 Downregulates Helios Expression and Suppresses the Function of Regulatory T Cells.
    Title: RNA-Binding Protein ZFP36L2 Downregulates Helios Expression and Suppresses the Function of Regulatory T Cells.
  4. Our results demonstrated that...Helios has a specific and important role for a correct function of hippocampal calbindin-positive CA1 pyramidal neurons regulating spinogenesis...and that Visinin-like protein 1 (VSNL1) could play an important role in such processes
    Title: Helios modulates the maturation of a CA1 neuronal subpopulation required for spatial memory formation.
  5. CD4+ Tconv cells can differentiate into both RORgamma+ and Helios+ pTreg cells.
    Title: Developmental and cellular age direct conversion of CD4+ T cells into RORγ+ or Helios+ colon Treg cells.
  6. Data show that zinc finger protein subfamily 1A 2 (Helios)Helios(+) and Helios(-) Treg subpopulations are phenotypically and functionally distinct and express dissimilar TCR repertoires.
    Title: Helios(+) and Helios(-) Treg subpopulations are phenotypically and functionally distinct and express dissimilar TCR repertoires.
  7. The transcription factor Helios, a member of the Ikaros transcription factor family, is expressed in 60-70% of Treg cells in both mouse and man, and is believed to be a marker of tTreg cells.
    Title: Helios: still behind the clouds.
  8. identification of Ikzf2 (which encodes Helios) as an essential transcription factor in mice that is required for outer hair cells functional maturation and hearing
    Title: Helios is a key transcriptional regulator of outer hair cell maturation.
  9. These data provide a genetic basis for the unstable phenotype of Helios-deficient Tregs within the inflammatory environment of tumors and suggest that immune milieu-dependent alterations in gene expression are a central feature of Treg conversion.
    Title: Comparative transcriptome analysis reveals distinct genetic modules associated with Helios expression in intratumoral regulatory T cells.
  10. He is involved in the correct development of a subset of striatopallidal medium spiny neurons.
    Title: Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein Helios
Names
ikaros family zinc finger protein 2
zinc finger protein, subfamily 1A, 2 (Helios)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001402850.1 → NP_001389779.1  zinc finger protein Helios isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC101737

  2. NM_001402852.1 → NP_001389781.1  zinc finger protein Helios isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC101737
    UniProtKB/Swiss-Prot
    Q8C8A3

  3. NM_001402853.1 → NP_001389782.1  zinc finger protein Helios isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC101737
    UniProtKB/Swiss-Prot
    Q8C8A3

  4. NM_001402854.1 → NP_001389783.1  zinc finger protein Helios isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC101737
    UniProtKB/Swiss-Prot
    Q8C8A3

  5. NM_001402855.1 → NP_001389784.1  zinc finger protein Helios isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC101737

  6. NM_001402856.1 → NP_001389785.1  zinc finger protein Helios isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC101737

  7. NM_001402857.1 → NP_001389786.1  zinc finger protein Helios isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC101737
    UniProtKB/Swiss-Prot
    Q8C8A3

  8. NM_011770.5 → NP_035900.2  zinc finger protein Helios isoform 2

    See identical proteins and their annotated locations for NP_035900.2

    Status: VALIDATED

    Source sequence(s)
    AC101737
    Consensus CDS
    CCDS15026.1
    UniProtKB/Swiss-Prot
    P81183, Q8C8A3
    Related
    ENSMUSP00000027146.3, ENSMUST00000027146.9
    Conserved Domains (2) summary
    sd00017
    Location:114 → 134
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:154 → 179
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    69570366..69726510 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164628.1 → XP_036020521.1  zinc finger protein Helios isoform X9

    Conserved Domains (3) summary
    COG5048
    Location:108 → 182
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:117 → 137
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:129 → 154
    zf-H2C2_2; Zinc-finger double domain

  2. XM_006495965.3 → XP_006496028.1  zinc finger protein Helios isoform X5

    Conserved Domains (2) summary
    sd00017
    Location:115 → 135
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:155 → 180
    zf-H2C2_2; Zinc-finger double domain

  3. XM_036164623.1 → XP_036020516.1  zinc finger protein Helios isoform X5

    Conserved Domains (2) summary
    sd00017
    Location:115 → 135
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:155 → 180
    zf-H2C2_2; Zinc-finger double domain

  4. XM_030253862.2 → XP_030109722.1  zinc finger protein Helios isoform X2

    Conserved Domains (2) summary
    sd00017
    Location:137 → 157
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:177 → 202
    zf-H2C2_2; Zinc-finger double domain

  5. XM_030253878.2 → XP_030109738.1  zinc finger protein Helios isoform X10

    Related
    ENSMUSP00000141075.2, ENSMUST00000187184.7
    Conserved Domains (3) summary
    COG5048
    Location:107 → 181
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:116 → 136
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:128 → 153
    zf-H2C2_2; Zinc-finger double domain

  6. XM_006495966.5 → XP_006496029.1  zinc finger protein Helios isoform X6

    UniProtKB/Swiss-Prot
    P81183
    Conserved Domains (2) summary
    sd00017
    Location:114 → 134
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:154 → 179
    zf-H2C2_2; Zinc-finger double domain

  7. XM_017320399.1 → XP_017175888.1  zinc finger protein Helios isoform X6

    UniProtKB/Swiss-Prot
    P81183
    Conserved Domains (2) summary
    sd00017
    Location:114 → 134
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:154 → 179
    zf-H2C2_2; Zinc-finger double domain

  8. XM_030253863.2 → XP_030109723.1  zinc finger protein Helios isoform X2

    Conserved Domains (2) summary
    sd00017
    Location:137 → 157
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:177 → 202
    zf-H2C2_2; Zinc-finger double domain

  9. XM_030253867.2 → XP_030109727.1  zinc finger protein Helios isoform X3

    Conserved Domains (2) summary
    sd00017
    Location:121 → 141
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:161 → 186
    zf-H2C2_2; Zinc-finger double domain

  10. XM_006495961.4 → XP_006496024.1  zinc finger protein Helios isoform X4

    UniProtKB/TrEMBL
    A0A087WNY4
    Related
    ENSMUSP00000139543.2, ENSMUST00000190771.7
    Conserved Domains (2) summary
    sd00017
    Location:120 → 140
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:160 → 185
    zf-H2C2_2; Zinc-finger double domain

  11. XM_006495968.4 → XP_006496031.1  zinc finger protein Helios isoform X8

    Conserved Domains (3) summary
    COG5048
    Location:130 → 204
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:139 → 159
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:151 → 176
    zf-H2C2_2; Zinc-finger double domain

  12. XM_006495959.4 → XP_006496022.1  zinc finger protein Helios isoform X2

    Conserved Domains (2) summary
    sd00017
    Location:137 → 157
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:177 → 202
    zf-H2C2_2; Zinc-finger double domain

  13. XM_006495967.4 → XP_006496030.1  zinc finger protein Helios isoform X6

    UniProtKB/Swiss-Prot
    P81183
    Conserved Domains (2) summary
    sd00017
    Location:114 → 134
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:154 → 179
    zf-H2C2_2; Zinc-finger double domain

  14. XM_011238508.3 → XP_011236810.1  zinc finger protein Helios isoform X5

    See identical proteins and their annotated locations for XP_011236810.1

    Conserved Domains (2) summary
    sd00017
    Location:115 → 135
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:155 → 180
    zf-H2C2_2; Zinc-finger double domain

  15. XM_011238509.3 → XP_011236811.1  zinc finger protein Helios isoform X7

    Conserved Domains (3) summary
    COG5048
    Location:131 → 205
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:140 → 160
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:152 → 177
    zf-H2C2_2; Zinc-finger double domain

  16. XM_011238504.3 → XP_011236806.1  zinc finger protein Helios isoform X1

    Conserved Domains (2) summary
    sd00017
    Location:138 → 158
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:178 → 203
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P81183.2 GenPept UniProtKB/Swiss-Prot:P81183

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